R. Phillips Heine, MD



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Professor of Obstetrics and Gynecology
Professor in Pediatrics
Division Chief, Maternal-Fetal Medicine
Vice Chair, Administrative Affairs
Department / Division:
Obstetrics/Gynecology / Maternal-Fetal Medicine
DUMC 3967
Durham, NC 27710
Appointment Telephone:
Office Telephone:
Admin: 919-681-7861; Records and prescriptions: 919-681-1397
  • MD, Texas Tech University School of Medicine, 1986
  • OB-GYN, UNC Hospitals, 1990
  • Sexually Transmitted Diseases, UNC Hospitals, 1991
  • Maternal-Fetal Medicine, University of Colorado Health Science Center, Denver, 1993
Clinical Interests:
High-risk obstetrics with an emphasis on medical complications of pregnancy, infectious diseases in pregnancy, preterm labor and delivery
Representative Publications:
  • Ellestad, SC; Swamy, GK; Sinclair, T; James, AH; Heine, RP; Murtha, AP. Preterm premature rupture of membrane management--inpatient versus outpatient: a retrospective review. American Journal of Perinatology: neonatal and maternal-fetal medicine. 2008;25:69-73.  Abstract
  • Murtha, AP; Sinclair, T; Hauser, ER; Swamy, GK; Herbert, WN; Heine, RP. Maternal serum cytokines in preterm premature rupture of membranes. Obstetrics and Gynecology. 2007;109:121-127.  Abstract
  • Pollak, KI; Oncken, CA; Lipkus, IM; Lyna, P; Swamy, GK; Pletsch, PK; Peterson, BL; Heine, RP; Brouwer, RJ; Fish, L; Myers, ER. Nicotine replacement and behavioral therapy for smoking cessation in pregnancy. American Journal of Preventive Medicine. 2007;33:297-305.  Abstract
  • Simhan, HN; Anderson, BL; Krohn, MA; Heine, RP; Martinez de Tejada, B; Landers, DV; Hillier, SL. Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy. American Journal of Obstetrics and Gynecology. 2007;196:59.e1-59.e5.  Abstract
  • Mills, AA; Yonish, B; Feng, L; Schomberg, DW; Heine, RP; Murtha, AP. Characterization of progesterone receptor isoform expression in fetal membranes. American Journal of Obstetrics and Gynecology. 2006;195:998-1003.  Abstract
  • Murtha, AP; Nieves, A; Hauser, ER; Swamy, GK; Yonish, BA; Sinclair, TR; Heine, RP. Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth. American Journal of Obstetrics and Gynecology. 2006;195:1249-1253.  Abstract
  • Sutkin, G; Krohn, MA; Heine, RP; Sweet, RL. Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis. Obstetrics and Gynecology. 2005;105:581-586.  Abstract
  • Swamy, GK; Simhan, HN; Gammill, HS; Heine, RP. Clinical utility of fetal fibronectin for predicting preterm birth. Journal of Reproductive Medicine: for the obstetrician and gynecologist. 2005;50:851-856.  Abstract
  • Klebanoff, MA; Hauth, JC; MacPherson, CA; Carey, JC; Heine, RP; Wapner, RJ; Iams, JD; Moawad, A; Miodovnik, M; Sibai, BM; vanDorsten, JP; Dombrowski, MP; National Institute for Child Health and Development Maternal Fetal Medicine Units Network. Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. American Journal of Obstetrics and Gynecology. 2004;190:363-370.  Abstract
  • Landers, DV; Wiesenfeld, HC; Heine, RP; Krohn, MA; Hillier, SL. Predictive value of the clinical diagnosis of lower genital tract infection in women. American Journal of Obstetrics and Gynecology. 2004;190:1004-1010.  Abstract
  • Simhan, H; Krohn, M; Heine, RP. Obstetric rectal injury: risk factors and the role of physician experience. The Journal of Maternal-Fetal and Neonatal Medicine. 2004;16:271-274.  Abstract
  • Balu, RB; Savitz, DA; Ananth, CV; Hartmann, KE; Miller, WC; Thorp, JM; Heine, RP. Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth. Obstetrics and Gynecology. 2003;101:862-868.  Abstract
  • Brancazio, LR; Murtha, AP; Heine, RP. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. New England Journal of Medicine. 2003;349:1087-1088.  Abstract
  • Grable, IA; Heine, RP. Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes?. American Journal of Obstetrics and Gynecology. 2003;189:808-812.  Abstract
  • Heine, RP; Ness, RB; Roberts, JM. Seroprevalence of antibodies to Chlamydia pneumoniae in women with preeclampsia. Obstetrics and Gynecology. 2003;101:221-226.  Abstract