Susan Kay Murphy, PhD, BA

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Associate Professor in Obstetrics and Gynecology
Associate Professor in Pathology
Department / Division:
Obstetrics/Gynecology / Gynecology Oncology
Address:
226 B Wing LSRC
450 Research Drive
Durham, NC 27708
Office Telephone:
(919) 681-3423
Training:
  • PhD, Wake Forest University, 1998
  • BA, University of North Carolina at Charlotte, 1992
Research Interests:
Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease
Representative Publications:
  • Murphy, SK; Adigun, A; Huang, Z; Overcash, F; Wang, F; Jirtle, RL; Schildkraut, JM; Murtha, AP; Iversen, ES; Hoyo, C. Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Gene. 2012;494:36-43.  Abstract
  • Murphy, SK; Huang, Z; Hoyo, C. Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues. PLoS One. 2012;7:e40924.  Abstract
  • Matsumura, N; Huang, Z; Mori, S; Baba, T; Fujii, S; Konishi, I; Iversen, ES; Berchuck, A; Murphy, SK. Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Research. 2011;21:74-82.  Abstract
  • Kondoh, E; Mori, S; Yamaguchi, K; Baba, T; Matsumura, N; Cory Barnett, J; Whitaker, RS; Konishi, I; Fujii, S; Berchuck, A; Murphy, SK. Targeting slow-proliferating ovarian cancer cells. International Journal of Cancer. 2010;126:2448-2456.  Abstract
  • Lee, PS; Teaberry, VS; Bland, AE; Huang, Z; Whitaker, RS; Baba, T; Fujii, S; Secord, AA; Berchuck, A; Murphy, SK. Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. International Journal of Cancer. 2010;126:1378-1389.  Abstract
  • Murphy, SK. Targeting ovarian cancer-initiating cells. Anti-Cancer Agents in Medicinal Chemistry. 2010;10:157-163.  Abstract
  • Yamaguchi, K; Mandai, M; Oura, T; Matsumura, N; Hamanishi, J; Baba, T; Matsui, S; Murphy, SK; Konishi, I. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. Oncogene. 2010;29:1741-1752.  Abstract
  • Baba, T; Convery, PA; Matsumura, N; Whitaker, RS; Kondoh, E; Perry, T; Huang, Z; Bentley, RC; Mori, S; Fujii, S; Marks, JR; Berchuck, A; Murphy, SK. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene. 2009;28:209-218.  Abstract
  • Hoyo, C; Murphy, SK; Jirtle, RL. Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. Journal of Epidemiology and Community Health. 2009;63:683-684.  Abstract
  • Matsumura, N; Huang, Z; Baba, T; Lee, PS; Barnett, JC; Mori, S; Chang, JT; Kuo, WL; Gusberg, AH; Whitaker, RS; Gray, JW; Fujii, S; Berchuck, A; Murphy, SK. Yin yang 1 modulates taxane response in epithelial ovarian cancer. Molecular Cancer Research. 2009;7:210-220.  Abstract
  • Price, TM; Murphy, SK; Younglai, EV. Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors. Toxicological Sciences. 2007;96:218-226.  Abstract
  • Weidman, JR; Dolinoy, DC; Murphy, SK; Jirtle, RL. Cancer susceptibility: epigenetic manifestation of environmental exposures. The Cancer Journal. 2007;13:9-16.  Abstract
  • Huang, Z; Wen, Y; Shandilya, R; Marks, JR; Berchuck, A; Murphy, SK. High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer. Nucleic Acids Research. 2006;34:555-563.  Abstract
  • Murphy, SK; Huang, Z; Wen, Y; Spillman, MA; Whitaker, RS; Simel, LR; Nichols, TD; Marks, JR; Berchuck, A. Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. Molecular Cancer Research. 2006;4:283-292.  Abstract
  • Murphy, SK; Nolan, CM; Huang, Z; Kucera, KS; Freking, BA; Smith, TP; Leymaster, KA; Weidman, JR; Jirtle, RL. Callipyge mutation affects gene expression in cis: a potential role for chromatin structure. Genome Research. 2006;16:340-346.  Abstract
  • Berchuck, A; Iversen, ES; Lancaster, JM; Pittman, J; Luo, J; Lee, P; Murphy, S; Dressman, HK; Febbo, PG; West, M; Nevins, JR; Marks, JR. Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers. Clinical Cancer Research. 2005;11:3686-3696.  Abstract
  • Murphy, SK; Freking, BA; Smith, TP; Leymaster, K; Nolan, CM; Wylie, AA; Evans, HK; Jirtle, RL. Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep. Mammalian Genome. 2005;16:171-183.  Abstract
  • Murphy, SK; Jirtle, RL. Imprinting evolution and the price of silence. BioEssays. 2003;25:577-588.  Abstract
  • Murphy, SK; Wylie, AA; Coveler, KJ; Cotter, PD; Papenhausen, PR; Sutton, VR; Shaffer, LG; Jirtle, RL. Epigenetic detection of human chromosome 14 uniparental disomy. Human Mutation. 2003;22:92-97.  Abstract
  • Freking, BA; Murphy, SK; Wylie, AA; Rhodes, SJ; Keele, JW; Leymaster, KA; Jirtle, RL; Smith, TP. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals. Genome Research. 2002;12:1496-1506.  Abstract
  • Murphy, SK; Wylie, AA; Jirtle, RL. Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. Genomics. 2001;71:110-117.  Abstract
  • Murphy, SK; Jirtle, RL. Imprinted genes as potential genetic and epigenetic toxicologic targets. Environmental Health Perspectives. 2000;108 Suppl 1:5-11.  Abstract
  • Wylie, AA; Murphy, SK; Orton, TC; Jirtle, RL. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Research. 2000;10:1711-1718.  Abstract