Patil, AS, Swamy, GK, Murtha, AP, Heine, RP, Zheng, X, and Grotegut, CA. "Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model." Reproductive sciences (Thousand Oaks, Calif.) 22, no. 12 (December 2015): 1577-1586.
Amy Patricia Murtha, MD
Dr. Amy Murtha is a Professor in the Department of Obstetrics and Gynecology and Department of Pediatrics, and past Vice Chair for Research in Obstetrics and Gynecology. After graduating from the Medical College of Pennsylvania in 1992 she completed her residency in OB-GYN and fellowship in Maternal Fetal Medicine (MFM) at Duke University then joined the faculty at Duke in 1998.
Dr. Murtha served as interim Chair for the Department of OB-GYN and Fellowship Director for the maternal fetal medicine division. She is currently Clinical Research Unit (CRU) Director and Program Director for the NIH-funded K12 training grant Building Interdisciplinary Research Careers in Women’s Health (BIRCWH). As a leader in research administration, Dr. Murtha has created an environment for the oversight of research in a way that is beneficial to the entire enterprise.
Dr. Murtha’s research career has focused primarily on preterm delivery and specifically on preterm premature rupture of membranes (PPROM). As a clinician scientist, she has the unique perspective of understanding the clinical implications of both basic and laboratory research. The Perinatal Research Initiative, led by Dr. Murtha and funded through philanthropic dollars, has allowed for growth in the size and scope of her lab. In addition to advancing the understanding of the etiology of preterm birth she has also focused on training the next generation of physician scientists in translational and molecular biology techniques with over 75 publications. Dr. Murtha uses her experiences and leadership skills to create an environment of supportive, collaborative, financially responsible research at Duke that aligns with the missions of the School of Medicine and the Duke University Health System.
Education and Training
- Resident, Obstetrics & Gynecology, Duke University, 1992 - 1996
- M.D., Drexel University, 1992
Selected Grants and Awards
- Building Interdisciplinary Research Careers in Women's Health
- Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development
- Hypoxic Ischemic Encephalopathy-Phase II-Robertson Foundation
- Endocrinology and Metabolism Training Program
- Novel Coherence Imaging to Evaluate the Health of the Cervical Epithelium
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program
- Role of the Vaginal Microbiome in Preterm Birth
- Novel Determination of Microbicide PK in Women's Reproductive Health
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
- Obesity and deregulation of imprinted genes in early life
- Pregnancy Outcomes and 17P
- Nutrition, Deregulation of Imprinted Genes
- Preterm Delivery Impacts Reproductive Health: Understanding the Etiology
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Neuromuscular Injury and Recovery after Vaginal Delivery
King, KE, Darrah, TH, Money, E, Meentemeyer, R, Maguire, RL, Nye, MD, Michener, L, Murtha, AP, Jirtle, R, Murphy, SK, Mendez, MA, Robarge, W, Vengosh, A, and Hoyo, C. "Geographic clustering of elevated blood heavy metal levels in pregnant women." BMC public health 15 (October 9, 2015): 1035-.
Murtha, AP, and Menon, R. "Regulation of fetal membrane inflammation: a critical step in reducing adverse pregnancy outcome." American journal of obstetrics and gynecology 213, no. 4 (October 2015): 447-448.
Vidal, AC, Semenova, V, Darrah, T, Vengosh, A, Huang, Z, King, K, Nye, MD, Fry, R, Skaar, D, Maguire, R, Murtha, A, Schildkraut, J, Murphy, S, and Hoyo, C. "Maternal cadmium, iron and zinc levels, DNA methylation and birth weight." BMC pharmacology & toxicology 16 (July 15, 2015): 20-.
Allen, TK, Feng, L, Nazzal, M, Grotegut, CA, Buhimschi, IA, and Murtha, AP. "The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro." Anesthesia and analgesia 120, no. 5 (May 2015): 1085-1094.
Soubry, A, Murphy, SK, Wang, F, Huang, Z, Vidal, AC, Fuemmeler, BF, Kurtzberg, J, Murtha, A, Jirtle, RL, Schildkraut, JM, and Hoyo, C. "Newborns of obese parents have altered DNA methylation patterns at imprinted genes." Int J Obes (Lond) 39, no. 4 (April 2015): 650-657.
Pierce, S, Gilner, J, Brown, H, Murtha, AP, and Grotegut, CA. "Cigarette Smoke Increases Placental Adrenomedullin and Uterine Natural Killer Cell Recruitment - A Possible Role in Cigarette Smoke-Mediate Protection From Preeclampsia." REPRODUCTIVE SCIENCES 22 (March 2015): 289A-289A.
Feng, L, Allen, TK, Nazzal, MK, and Murtha, AP. "P4 and Progesterone Membrane Component 1 (PGRMC1) Inhibit Ureaplasma Parvum Induced Inflammation in Amnion and Chorion Cells." REPRODUCTIVE SCIENCES 22 (March 2015): 236A-237A.
Feng, L, Allen, TK, and Murtha, AP. "Role of P4 and Progesterone Receptor Membrane Component 1 (PGRMC1) in Sirtuin1 and Sirtuin 3 Regulation in Chorion Cells Under Oxidative Stress." REPRODUCTIVE SCIENCES 22 (March 2015): 326A-326A.
McCullough, LE, Mendez, MA, Miller, EE, Murtha, AP, Murphy, SK, and Hoyo, C. "Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort." Epigenetics 10, no. 7 (January 2015): 597-606.