Soubry, A, Murphy, SK, Wang, F, Huang, Z, Vidal, AC, Fuemmeler, BF, Kurtzberg, J, Murtha, A, Jirtle, RL, Schildkraut, JM, and Hoyo, C. "Newborns of obese parents have altered DNA methylation patterns at imprinted genes." International Journal of Obesity 39, no. 4 (January 1, 2015): 650-657.
Amy Patricia Murtha, MD
Dr. Amy Murtha is a Professor in the Department of Obstetrics and Gynecology and Department of Pediatrics, and past Vice Chair for Research in Obstetrics and Gynecology. After graduating from the Medical College of Pennsylvania in 1992 she completed her residency in OB-GYN and fellowship in Maternal Fetal Medicine (MFM) at Duke University then joined the faculty at Duke in 1998.
Dr. Murtha served as interim Chair for the Department of OB-GYN and Fellowship Director for the maternal fetal medicine division. She is currently Clinical Research Unit (CRU) Director and Program Director for the NIH-funded K12 training grant Building Interdisciplinary Research Careers in Women’s Health (BIRCWH). As a leader in research administration, Dr. Murtha has created an environment for the oversight of research in a way that is beneficial to the entire enterprise.
Dr. Murtha’s research career has focused primarily on preterm delivery and specifically on preterm premature rupture of membranes (PPROM). As a clinician scientist, she has the unique perspective of understanding the clinical implications of both basic and laboratory research. The Perinatal Research Initiative, led by Dr. Murtha and funded through philanthropic dollars, has allowed for growth in the size and scope of her lab. In addition to advancing the understanding of the etiology of preterm birth she has also focused on training the next generation of physician scientists in translational and molecular biology techniques with over 75 publications. Dr. Murtha uses her experiences and leadership skills to create an environment of supportive, collaborative, financially responsible research at Duke that aligns with the missions of the School of Medicine and the Duke University Health System.
Education and Training
- Resident, Obstetrics & Gynecology, Duke University, 1992 - 1996
- M.D., Drexel University, 1992
Selected Grants and Awards
- Building Interdisciplinary Research Careers in Women's Health
- Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development
- Hypoxic Ischemic Encephalopathy-Phase II-Robertson Foundation
- Endocrinology and Metabolism Training Program
- Novel Coherence Imaging to Evaluate the Health of the Cervical Epithelium
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program
- Role of the Vaginal Microbiome in Preterm Birth
- Novel Determination of Microbicide PK in Women's Reproductive Health
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
- Obesity and deregulation of imprinted genes in early life
- Pregnancy Outcomes and 17P
- Nutrition, Deregulation of Imprinted Genes
- Preterm Delivery Impacts Reproductive Health: Understanding the Etiology
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Neuromuscular Injury and Recovery after Vaginal Delivery
Matson, BC, Corty, RW, Karpinich, NO, Murtha, AP, Valdar, W, Grotegut, CA, and Caron, KM. "[305-POS]: Plasma concentrations of midregional pro-adrenomedullin are blunted in women with severe preeclampsia." Pregnancy hypertension 5, no. 1 (January 2015): 150-151.
Murtha, AP, and Edwards, JM. "The role of Mycoplasma and Ureaplasma in adverse pregnancy outcomes." Obstetrics and gynecology clinics of North America 41, no. 4 (December 2014): 615-627. (Review)
Nye, MD, Hoyo, C, Wang, F, Murtha, AP, Schildkraut, JM, Kurtzberg, J, Jirtle, RL, Huang, Z, and Murphy, SK. "Abstract B22: Altered methylation profiles of imprinted genes in response to prenatal exposure to cigarette smoke in the Newborn Epigenetic STudy (NEST) cohort." Cancer Epidemiology Biomarkers & Prevention 23, no. 11 Supplement (November 2014): B22-B22.
Patil, AS, Patil, NP, Lewis, AN, Swamy, GK, and Murtha, AP. "Health care providers' use of a drug information service for pregnancy-related inquiries." Journal of the American Pharmacists Association : JAPhA 54, no. 5 (September 2014): 502-509.
Matson, BC, Corty, RW, Karpinich, NO, Murtha, AP, Valdar, W, Grotegut, CA, and Caron, KM. "Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia." Placenta 35, no. 9 (September 2014): 780-783.
Hoyo, C, Daltveit, AK, Iversen, E, Benjamin-Neelon, SE, Fuemmeler, B, Schildkraut, J, Murtha, AP, Overcash, F, Vidal, AC, Wang, F, Huang, Z, Kurtzberg, J, Seewaldt, V, Forman, M, Jirtle, RL, and Murphy, SK. "Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort." Epigenetics 9, no. 8 (August 2014): 1120-1130.
Cotten, CM, Murtha, AP, Goldberg, RN, Grotegut, CA, Smith, PB, Goldstein, RF, Fisher, KA, Gustafson, KE, Waters-Pick, B, Swamy, GK, Rattray, B, Tan, S, and Kurtzberg, J. "Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy." J Pediatr 164, no. 5 (May 2014): 973-979.e1.
Feng, L, Antczak, BC, Lan, L, Grotegut, CA, Thompson, JL, Allen, TK, and Murtha, AP. "Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)." Placenta 35, no. 5 (May 2014): 331-333.
Ahmadzia, HK, Thomas, SM, Heine, RP, Murtha, AP, and Brancazio, LR. "Survey of peripartum hysterectomy experiences: anticipated, unplanned, or averted." Obstetrics and gynecology 123 Suppl 1 (May 2014): 134S-.