Fortner, KB, Fitzpatrick, CB, Grotegut, CA, Swamy, GK, Murtha, AP, Heine, RP, and Brown, HL. "Cervical dilation as a predictor of pregnancy outcome following emergency cerclage." J Matern Fetal Neonatal Med 25, no. 10 (October 2012): 1884-1888.
Amy Patricia Murtha, MD
Dr. Amy Murtha is a Professor in the Department of Obstetrics and Gynecology and Department of Pediatrics, and past Vice Chair for Research in Obstetrics and Gynecology. After graduating from the Medical College of Pennsylvania in 1992 she completed her residency in OB-GYN and fellowship in Maternal Fetal Medicine (MFM) at Duke University then joined the faculty at Duke in 1998.
Dr. Murtha served as interim Chair for the Department of OB-GYN and Fellowship Director for the maternal fetal medicine division. She is currently Clinical Research Unit (CRU) Director and Program Director for the NIH-funded K12 training grant Building Interdisciplinary Research Careers in Women’s Health (BIRCWH). As a leader in research administration, Dr. Murtha has created an environment for the oversight of research in a way that is beneficial to the entire enterprise.
Dr. Murtha’s research career has focused primarily on preterm delivery and specifically on preterm premature rupture of membranes (PPROM). As a clinician scientist, she has the unique perspective of understanding the clinical implications of both basic and laboratory research. The Perinatal Research Initiative, led by Dr. Murtha and funded through philanthropic dollars, has allowed for growth in the size and scope of her lab. In addition to advancing the understanding of the etiology of preterm birth she has also focused on training the next generation of physician scientists in translational and molecular biology techniques with over 75 publications. Dr. Murtha uses her experiences and leadership skills to create an environment of supportive, collaborative, financially responsible research at Duke that aligns with the missions of the School of Medicine and the Duke University Health System.
Education and Training
- Resident, Obstetrics & Gynecology, Duke University, 1992 - 1996
- M.D., Drexel University, 1992
Selected Grants and Awards
- Building Interdisciplinary Research Careers in Women's Health
- Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development
- Hypoxic Ischemic Encephalopathy-Phase II-Robertson Foundation
- Endocrinology and Metabolism Training Program
- Novel Coherence Imaging to Evaluate the Health of the Cervical Epithelium
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program
- Role of the Vaginal Microbiome in Preterm Birth
- Novel Determination of Microbicide PK in Women's Reproductive Health
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
- Obesity and deregulation of imprinted genes in early life
- Pregnancy Outcomes and 17P
- Nutrition, Deregulation of Imprinted Genes
- Preterm Delivery Impacts Reproductive Health: Understanding the Etiology
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Neuromuscular Injury and Recovery after Vaginal Delivery
Canzoneri, BJ, Grotegut, CA, Swamy, GK, Brancazio, LR, Sinclair, T, Heine, PR, and Murtha, AP. "Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics." J Matern Fetal Neonatal Med 25, no. 8 (August 2012): 1329-1332.
Liu, Y, Murphy, SK, Murtha, AP, Fuemmeler, BF, Schildkraut, J, Huang, Z, Overcash, F, Kurtzberg, J, Jirtle, R, Iversen, ES, Forman, MR, and Hoyo, C. "Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements." Epigenetics 7, no. 7 (July 2012): 735-746.
Perkins, E, Murphy, SK, Murtha, AP, Schildkraut, J, Jirtle, RL, Demark-Wahnefried, W, Forman, MR, Kurtzberg, J, Overcash, F, Huang, Z, and Hoyo, C. "Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children." J Pediatr 161, no. 1 (July 2012): 31-39.
Beiswenger, TR, Feng, L, Brown, HL, Heine, RP, Murtha, AP, and Grotegut, CA. "The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin." Reprod Sci 19, no. 5 (May 2012): 526-533.
Hoyo, C, Fortner, K, Murtha, AP, Schildkraut, JM, Soubry, A, Demark-Wahnefried, W, Jirtle, RL, Kurtzberg, J, Forman, MR, Overcash, F, Huang, Z, and Murphy, SK. "Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight." Cancer Causes Control 23, no. 4 (April 2012): 635-645.
Ransom, CE, Seed, PC, Fortner, KB, Feng, L, Lan, L, Yu, M, and Murtha, AP. "Differential Cytokine and Tissue Remodeling Responses in Chorion and Decidua Exposed to Ureaplasma parvum." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 362A-363A.
Feng, L, Antczak, B, Thompson, J, Grotegut, CA, and Murtha, AP. "PGRMC1 Expression in Fetal Membrane Layers among Women with Preterm Premature Rupture of the Membranes (PPROM)." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 295A-295A.
Ransom, CE, and Murtha, AP. "Progesterone for preterm birth prevention." Obstet Gynecol Clin North Am 39, no. 1 (March 2012): 1-vii. (Review)
Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progestins Diminish Cytokine Induced MMP9 Activity in a Human Cytotrophoblast Cell Line Not Expressing the Nuclear Progesterone Receptor." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 294A-294A.