Murphy, SK, Adigun, A, Huang, Z, Overcash, F, Wang, F, Jirtle, RL, Schildkraut, JM, Murtha, AP, Iversen, ES, and Hoyo, C. "Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke." Gene 494, no. 1 (February 15, 2012): 36-43.
Amy Patricia Murtha, MD
Dr. Amy Murtha is a Professor in the Department of Obstetrics and Gynecology and Department of Pediatrics, and Vice Chair for Research in Obstetrics and Gynecology. After graduating from the Medical College of Pennsylvania in 1992 she completed her residency in OB-GYN and fellowship in Maternal Fetal Medicine (MFM) at Duke University then joined the faculty at Duke in 1998.
Dr. Murtha served as interim Chair for the Department of OB-GYN and Fellowship Director for the maternal fetal medicine division. She is currently Clinical Research Unit (CRU) Director and Program Director for the NIH-funded K12 training grant Building Interdisciplinary Research Careers in Women’s Health (BIRCWH). As a leader in research administration, Dr. Murtha has created an environment for the oversight of research in a way that is beneficial to the entire enterprise.
Dr. Murtha’s research career has focused primarily on preterm delivery and specifically on preterm premature rupture of membranes (PPROM). As a clinician scientist, she has the unique perspective of understanding the clinical implications of both basic and laboratory research. The Perinatal Research Initiative, led by Dr. Murtha and funded through philanthropic dollars, has allowed for growth in the size and scope of her lab. In addition to advancing the understanding of the etiology of preterm birth she has also focused on training the next generation of physician scientists in translational and molecular biology techniques with over 75 publications. Dr. Murtha uses her experiences and leadership skills to create an environment of supportive, collaborative, financially responsible research at Duke that aligns with the missions of the School of Medicine and the Duke University Health System.
Education and Training
- Resident, Obstetrics & Gynecology, Duke University, 1992 - 1996
- M.D., Drexel University, 1992
Selected Grants and Awards
- Building Interdisciplinary Research Careers in Women's Health
- Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development
- Endocrinology and Metabolism Training Program
- Novel Coherence Imaging to Evaluate the Health of the Cervical Epithelium
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program
- Hypoxic Ischemic Encephalopathy-Phase II-Robertson Foundation
- Role of the Vaginal Microbiome in Preterm Birth
- Novel Determination of Microbicide PK in Women's Reproductive Health
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
- Obesity and deregulation of imprinted genes in early life
- Pregnancy Outcomes and 17P
- Nutrition, Deregulation of Imprinted Genes
- Preterm Delivery Impacts Reproductive Health: Understanding the Etiology
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Neuromuscular Injury and Recovery after Vaginal Delivery
Myatt, L, Eschenbach, DA, Lye, SJ, Mesiano, S, Murtha, AP, Williams, SM, and Pennell, CE. "A standardized template for clinical studies in preterm birth." Reproductive Sciences 19, no. 5 (2012): 474-482.
Brandon, DH, Tully, KP, Silva, SG, Malcolm, WF, Murtha, AP, Turner, BS, and Holditch-Davis, D. "Emotional responses of mothers of late-preterm and term infants." J Obstet Gynecol Neonatal Nurs 40, no. 6 (November 2011): 719-731.
Soubry, A, Murphy, S, Huang, Z, Murtha, A, Schildkraut, J, Jirtle, R, Wang, F, Kurtzberg, J, Demark-Wahnefried, W, Forman, M, and Hoyo, C. "The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring. (Published online)" Clin Epigenetics 3 (October 26, 2011): 2-.
Grotegut, CA, Murtha, AP, and Rockman, HA. "MSH-releasing Inhibitor Factor (pro-leu-gly-NH2) Acts as an Allosteric Activator for Oxytocin-induced MAPK Signaling but Does Not Affect Uterine Contractility." JOURNAL OF WOMENS HEALTH 20, no. 10 (October 2011): 1392-1392.
Hoyo, C, Murtha, AP, Schildkraut, JM, Jirtle, RL, Demark-Wahnefried, W, Forman, MR, Iversen, ES, Kurtzberg, J, Overcash, F, Huang, Z, and Murphy, SK. "Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy." Epigenetics 6, no. 7 (July 2011): 928-936.
Grotegut, CA, Johnson, LNC, Fitzpatrick, CB, Heine, RP, Swamy, GK, and Murtha, AP. "Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes." BJOG 118, no. 6 (May 2011): 735-740.
Fortner, KB, Ransom, CE, Canzoneri, BJ, Bentley, RC, Feng, L, Seed, PC, and Murtha, AP. "Bacteria Localization in Fetal Membranes among Subjects with Preterm Premature Rupture of Membranes." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 238A-238A.
Feng, L, Grotegut, C, Schomberg, D, and Murtha, AP. "Progesterone Receptor Membrane Component 1 Mediated Signaling Inhibits Increase in Intracellular Ca2+ in Human Cytotrophoblast Cells." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 312A-313A.
Reddick, KLB, Murtha, AP, Grotegut, CA, James, AH, Swamy, GK, and Brancazio, LR. "The Effects of Intermittent Pneumatic Compression on Fibrinolysis during Cesarean Delivery." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 380A-381A.