Grotegut, CA, Feng, L, Mao, L, Heine, RP, Murtha, AP, and Rockman, HA. "β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration." Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468-E477.
Amy Patricia Murtha, MD
Dr. Amy Murtha is a Professor in the Department of Obstetrics and Gynecology and Department of Pediatrics, and past Vice Chair for Research in Obstetrics and Gynecology. After graduating from the Medical College of Pennsylvania in 1992 she completed her residency in OB-GYN and fellowship in Maternal Fetal Medicine (MFM) at Duke University then joined the faculty at Duke in 1998.
Dr. Murtha served as interim Chair for the Department of OB-GYN and Fellowship Director for the maternal fetal medicine division. She is currently Clinical Research Unit (CRU) Director and Program Director for the NIH-funded K12 training grant Building Interdisciplinary Research Careers in Women’s Health (BIRCWH). As a leader in research administration, Dr. Murtha has created an environment for the oversight of research in a way that is beneficial to the entire enterprise.
Dr. Murtha’s research career has focused primarily on preterm delivery and specifically on preterm premature rupture of membranes (PPROM). As a clinician scientist, she has the unique perspective of understanding the clinical implications of both basic and laboratory research. The Perinatal Research Initiative, led by Dr. Murtha and funded through philanthropic dollars, has allowed for growth in the size and scope of her lab. In addition to advancing the understanding of the etiology of preterm birth she has also focused on training the next generation of physician scientists in translational and molecular biology techniques with over 75 publications. Dr. Murtha uses her experiences and leadership skills to create an environment of supportive, collaborative, financially responsible research at Duke that aligns with the missions of the School of Medicine and the Duke University Health System.
Education and Training
- Resident, Obstetrics & Gynecology, Duke University, 1992 - 1996
- M.D., Drexel University, 1992
Selected Grants and Awards
- Building Interdisciplinary Research Careers in Women's Health
- Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development
- Hypoxic Ischemic Encephalopathy-Phase II-Robertson Foundation
- Endocrinology and Metabolism Training Program
- Novel Coherence Imaging to Evaluate the Health of the Cervical Epithelium
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program
- Role of the Vaginal Microbiome in Preterm Birth
- Novel Determination of Microbicide PK in Women's Reproductive Health
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
- Obesity and deregulation of imprinted genes in early life
- Pregnancy Outcomes and 17P
- Nutrition, Deregulation of Imprinted Genes
- Preterm Delivery Impacts Reproductive Health: Understanding the Etiology
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Neuromuscular Injury and Recovery after Vaginal Delivery
Hoyo, C, Murtha, AP, Schildkraut, JM, Forman, MR, Calingaert, B, Demark-Wahnefried, W, Kurtzberg, J, Jirtle, RL, and Murphy, SK. "Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). (Published online)" BMC Public Health 11, no. 1 (January 21, 2011): 46-.
Drake, TK, DeSoto, MG, Peters, JJ, Henderson, MH, Murtha, AP, Katz, DF, and Wax, A. "Design and validation of a multiplexed low coherence interferometry instrument for in vivo clinical measurement of microbicide gel thickness distribution." Biomedical Optics Express 2, no. 10 (2011): 2850-2858.
Ransom, CE, Chin, JR, Roeder, HA, Sinclair, TR, Heine, RP, and Murtha, AP. "The influence of prior obstetrical history on current 17-hydroxyprogesterone caproate use." J Pregnancy 2011 (2011): 286483-.
Bishop, TS, and Murtha, AP. "An Intervention to Maximize Research Sample Collection for Pregnant Subjects at Delivery." JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING 39 (September 2010): S97-S97.
Feng, L, and Murtha, AP. "R5020 Inhibits Calcium Ionophore-Induced Apoptosis in Trophoblast Cells by Regulating Intracellular Calcium." March 2010.
Offenbacher, S, Beck, JD, Jared, HL, Mauriello, SM, Mendoza, LC, Couper, DJ, Stewart, DD, Murtha, AP, Cochran, DL, Dudley, DJ, Reddy, MS, Geurs, NC, and Hauth, JC. "Effects of periodontal therapy on rate of preterm delivery: A randomized controlled trial." Obstetrical and Gynecological Survey 65, no. 1 (2010): 6-7.
Grotegut, CA, Murtha, AP, and Rockman, HA. "Beta-Arrestin Mediates Oxytocin Receptor Desensitization and MAPK Signaling Following Oxytocin Stimulation." REPRODUCTIVE SCIENCES 16, no. 3 (March 2009): 104A-104A.
Murtha, AP, Feng, L, Grotegut, C, and Schomberg, D. "Expression of COX2 and GPX2 Are Altered by Calcimycin but Not Progesterone in Fetal Chorion Cells." REPRODUCTIVE SCIENCES 16, no. 3 (March 2009): 295A-296A.
Offenbacher, S, Beck, JD, Jared, HL, Mauriello, SM, Mendoza, LC, Couper, DJ, Stewart, DD, Murtha, AP, Cochran, DL, Dudley, DJ, Reddy, MS, Geurs, NC, and Hauth, JC. "Effects of periodontal therapy on rate of preterm delivery: A randomized controlled trial." Obstetrics and Gynecology 114, no. 3 (2009): 551-559.