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Andrew Berchuck, MD

Andrew Berchuck, MD
James M. Ingram Professor of Gynecologic Oncology
Campus Mail: 25171 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: berch001@mc.duke.edu

Dr. Andrew Berchuck is Director of the Duke Division of Gynecologic Oncology and holds the James M. Ingram Distinguished Professorship. He is a practicing oncologist who is actively involved in the surgical and chemotherapy management of women with ovarian, endometrial and lower genital tract cancers. This includes minimally invasive laparoscopic surgical approaches. He also has developed a research program that focuses on the molecular-genetic alterations involved in malignant transformation of the ovarian and endometrial epithelium. He has published over 300 peer-reviewed papers in these areas. The objectives of his research include 1) identification of ovarian cancer susceptibility polymorphisms through a population-based case-control molecular epidemiologic study, and 2) use of genomic approaches  to elucidate the molecular heterogenetity of ovarian cancer. Thirty fellows and residents have worked in his lab, several of whom are now funded investigators. His research efforts have been recognized nationally and he has received awards for best oral presentation at the annual meetings of both the Society of Gynecologic Oncology and the International Gynecologic Cancer Society. Dr. Berchuck was awarded the Barbara Thomason Ovarian Cancer Research Professorship by the American Cancer Society in 2006. He has served as editor of several books in the field including Principles and Practice of Gynecologic Oncology. Dr. Berchuck also has a major commitment to national activities, and was President of the Society of Gynecologic Oncology in 2008. He served as chair of the scientific advisory committee of the Ovarian Cancer Research Fund (http://www.ocrf.org) in New York City. Finally, he is also head of the steering committee of the international Ovarian Cancer Association Consortium (OCAC), a group of 50 case-control studies that are working together to identify ovarian cancer susceptibility polymorphisms (www.srl.cam.ac.uk/consortia/ocac/index.html).

Education and Training

  • M.D., Case Western Reserve University, 1980

Research

Dr Berchuck is interested in the molecular pathogenesis of ovarian and endometrial cancer. 

View Publications

Selected Grants and Awards

Publications

Permuth-Wey, J, Reid, BM, Chen, YA, Lin, H-Y, Monteiro, A, Chen, Z, Berchuck, A, Chenevix-Trench, G, Doherty, J, Gayther, S, Goode, E, Iversen, E, Pearce, L, Pharoah, PDP, Phelan, C, Ramus, S, Rossing, MA, Schildkraut, J, and Sellers, T. "Abstract 4635: Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility." August 1, 2015.

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Winham, SJ, Fridley, BL, Larson, MC, Fogarty, Z, Berchuck, A, Chen, YA, Lin, H-Y, Chenevix-Trench, G, Permuth-Wey, J, Sellers, TA, Pirie, A, and Goode, EL. "Abstract 4636: Investigation of exome variants associated with overall survival in ovarian cancer." August 1, 2015.

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Kelemen, LE, Lawrenson, K, Tyrer, J, Li, Q, Lee, JM, Seo, J-H, Phelan, CM, Beesley, J, Chen, X, Spindler, TJ, Aben, KKH, Anton-Culver, H, Antonenkova, N, Australian Cancer Study, , Australian Ovarian Cancer Study Group, , and Ovarian Cancer Association Consortium, . "Genome-wide significant risk associations for mucinous ovarian carcinoma." Nature genetics 47, no. 8 (August 2015): 888-897.

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Coetzee, SG, Shen, HC, Hazelett, DJ, Lawrenson, K, Kuchenbaecker, K, Tyrer, J, Rhie, SK, Levanon, K, Karst, A, Drapkin, R, Ramus, SJ, Ovarian Cancer Association Consortium, The Consortium of Investigators of Modifiers of BRCA1/2, , Couch, FJ, Offit, K, Chenevix-Trench, G, Monteiro, ANA, Antoniou, A, Freedman, M, Coetzee, GA, Pharoah, PDP, Noushmehr, H, Gayther, SA, and Ovarian Cancer Association Consortium The Consortium of Investigators of Modifiers of BRCA1/2, . "Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci." Human molecular genetics 24, no. 13 (July 2015): 3595-3607.

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Ness, R, Pearce, C, Stram, D, Berchuck, A, Pike, M, and Pharoah, P. "LIFETIME RISK OF OVARIAN CANCER BASED ON ENDOMETRIOSIS AND OTHER RISK FACTORS." INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 25 (May 2015): 50-51.

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Ness, R, Pearce, C, Stram, D, Berchuck, A, Pike, M, and Pharoah, P. "LIFETIME RISK OF OVARIAN CANCER BASED ON ENDOMETRIOSIS AND OTHER RISK FACTORS: IGCS-0014 06. Ovarian Cancer." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 25 Suppl 1 (May 2015): 50-.

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Pearce, CL, Stram, DO, Ness, RB, Stram, DA, Roman, LD, Templeman, C, Lee, AW, Menon, U, Fasching, PA, McAlpine, JN, Doherty, JA, Modugno, F, Schildkraut, JM, Rossing, MA, Huntsman, DG, Wu, AH, Berchuck, A, Pike, MC, and Pharoah, PDP. "Population distribution of lifetime risk of ovarian cancer in the United States." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 24, no. 4 (April 2015): 671-676.

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Berchuck, A, Witkowski, L, Hasselblatt, M, and Foulkes, WD. "Prophylactic oophorectomy for hereditary small cell carcinoma of the ovary, hypercalcemic type." Gynecologic oncology reports 12 (April 2015): 20-22.

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Lee, AW, Tyrer, JP, Doherty, JA, Stram, DA, Kupryjanczyk, J, Dansonka-Mieszkowska, A, Plisiecka-Halasa, J, Spiewankiewicz, B, Myers, EJ, Australian Cancer Study (Ovarian Cancer), , Australian Ovarian Cancer Study Group, , Chenevix-Trench, G, Fasching, PA, Beckmann, MW, Ekici, AB, Hein, A, Vergote, I, Van Nieuwenhuysen, E, Lambrechts, D, Wicklund, KG, Eilber, U, Wang-Gohrke, S, Chang-Claude, J, Rudolph, A, Sucheston-Campbell, L, Odunsi, K, Moysich, KB, Shvetsov, YB, Thompson, PJ, Goodman, MT, Wilkens, LR, Dörk, T, Hillemanns, P, Dürst, M, Runnebaum, IB, Bogdanova, N, Pelttari, LM, Nevanlinna, H, Leminen, A, Edwards, RP, Kelley, JL, Harter, P, Schwaab, I, Heitz, F, du Bois, A, Orsulic, S, Lester, J, Walsh, C, Karlan, BY, Hogdall, E, Kjaer, SK, Jensen, A, Vierkant, RA, Cunningham, JM, Goode, EL, Fridley, BL, Southey, MC, Giles, GG, Bruinsma, F, Wu, X, Hildebrandt, MAT, Lu, K, Liang, D, Bisogna, M, Levine, DA, Weber, RP, Schildkraut, JM, Iversen, ES, Berchuck, A, Terry, KL, Cramer, DW, Tworoger, SS, Poole, EM, Olson, SH, Orlow, I, Bandera, EV, Bjorge, L, Tangen, IL, Salvesen, HB, Krakstad, C, Massuger, LFAG, Kiemeney, LA, Aben, KKH, van Altena, AM, Bean, Y, Pejovic, T, Kellar, M, Le, ND, Cook, LS, Kelemen, LE, Brooks-Wilson, A, Lubinski, J, Gronwald, J, Cybulski, C, Jakubowska, A, Wentzensen, N, Brinton, LA, Lissowska, J, Yang, H, Nedergaard, L, Lundvall, L, Hogdall, C, Song, H, Campbell, IG, Eccles, D, Glasspool, R, Siddiqui, N, Carty, K, Paul, J, McNeish, IA, Sieh, W, McGuire, V, Rothstein, JH, Whittemore, AS, McLaughlin, JR, Risch, HA, Phelan, CM, Anton-Culver, H, Ziogas, A, Menon, U, Ramus, SJ, Gentry-Maharaj, A, Harrington, P, Pike, MC, Modugno, F, Rossing, MA, Ness, RB, Pharoah, PDP, Stram, DO, Wu, AH, and Pearce, CL. "Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study." Gynecologic Oncology 136, no. 3 (March 2015): 542-548.

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Mo, L, Bachelder, RE, Kennedy, M, Chen, P-H, Chi, J-T, Berchuck, A, Cianciolo, G, and Pizzo, SV. "Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78." Molecular Cancer Therapeutics 14, no. 3 (March 2015): 747-756.

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