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Andrew Berchuck, MD

Andrew Berchuck, MD
James M. Ingram Professor of Gynecologic Oncology
Campus Mail: 25171 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: berch001@mc.duke.edu

Dr. Andrew Berchuck is Director of the Duke Division of Gynecologic Oncology and holds the James M. Ingram Distinguished Professorship. He is a practicing oncologist who is actively involved in the surgical and chemotherapy management of women with ovarian, endometrial and lower genital tract cancers. This includes minimally invasive laparoscopic surgical approaches. He also has developed a research program that focuses on the molecular-genetic alterations involved in malignant transformation of the ovarian and endometrial epithelium. He has published over 300 peer-reviewed papers in these areas. The objectives of his research include 1) identification of ovarian cancer susceptibility polymorphisms through a population-based case-control molecular epidemiologic study, and 2) use of genomic approaches  to elucidate the molecular heterogenetity of ovarian cancer. Thirty fellows and residents have worked in his lab, several of whom are now funded investigators. His research efforts have been recognized nationally and he has received awards for best oral presentation at the annual meetings of both the Society of Gynecologic Oncology and the International Gynecologic Cancer Society. Dr. Berchuck was awarded the Barbara Thomason Ovarian Cancer Research Professorship by the American Cancer Society in 2006. He has served as editor of several books in the field including Principles and Practice of Gynecologic Oncology. Dr. Berchuck also has a major commitment to national activities, and was President of the Society of Gynecologic Oncology in 2008. He served as chair of the scientific advisory committee of the Ovarian Cancer Research Fund (http://www.ocrf.org) in New York City. Finally, he is also head of the steering committee of the international Ovarian Cancer Association Consortium (OCAC), a group of 50 case-control studies that are working together to identify ovarian cancer susceptibility polymorphisms (www.srl.cam.ac.uk/consortia/ocac/index.html).

Education and Training

  • M.D., Case Western Reserve University, 1980

Research

Dr Berchuck is interested in the molecular pathogenesis of ovarian and endometrial cancer. 

View Publications

Selected Grants and Awards

Publications

Pearce, CL, Rossing, MA, Lee, AW, Ness, RB, Webb, PM, for Australian Cancer Study (Ovarian Cancer), , Australian Ovarian Cancer Study Group, , Chenevix-Trench, G, Jordan, SM, Stram, DA, Chang-Claude, J, Hein, R, Nickels, S, Lurie, G, Thompson, PJ, Carney, ME, Goodman, MT, Moysich, K, Hogdall, E, Jensen, A, Goode, EL, Fridley, BL, Cunningham, JM, Vierkant, RA, Weber, RP, Ziogas, A, Anton-Culver, H, Gayther, SA, Gentry-Maharaj, A, Menon, U, Ramus, SJ, Brinton, L, Wentzensen, N, Lissowska, J, Garcia-Closas, M, Massuger, LFAG, Kiemeney, LALM, Van Altena, AM, Aben, KKH, Berchuck, A, Doherty, JA, Iversen, E, McGuire, V, Moorman, PG, Pharoah, P, Pike, MC, Risch, H, Sieh, W, Stram, DO, Terry, KL, Whittemore, A, Wu, AH, Schildkraut, JM, Kjaer, SK, and Ovarian Cancer Association Consortium, . "Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 22, no. 5 (May 2013): 880-890.

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Cancer Genome Atlas Research Network, , Kandoth, C, Schultz, N, Cherniack, AD, Akbani, R, Liu, Y, Shen, H, Robertson, AG, Pashtan, I, Shen, R, Benz, CC, Yau, C, Laird, PW, Ding, L, Zhang, W, Mills, GB, Kucherlapati, R, Mardis, ER, and Levine, DA. "Integrated genomic characterization of endometrial carcinoma." Nature 497, no. 7447 (May 2013): 67-73.

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Amankwah, EK, Tyrer, J, Lin, H-Y, Tsai, Y-Y, Chen, Z, Han, G, Qu, X, Goode, E, Cunninghan, J, Iverson, E, Ramus, S, Berchuck, A, Schildkraut, J, Monteiro, A, Gayther, S, Narod, S, Pharoah, P, Sellers, TA, and Phelan, C. "Abstract 1352: Epithelial-mesenchymal transition (EMT) gene variants influence epithelial ovarian cancer risk in women of European, African and Asian ancestry." April 15, 2013.

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Siamakpour- Reihani, S, Jiang, C, Turner, T, Owzar, K, Berchuck, A, Dewhirst, M, and Alvarez Secord, A. "Abstract 330A: Differential expression of angiogenic genes in invasive high grade serous ovarian carcinomas." April 15, 2013.

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Park, J, Huang, Z, Berchuck, A, and Murphy, S. "Abstract 4767: Preclinical mouse model of recurrent epithelial ovarian cancer." April 15, 2013.

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Jim, H, Tyrer, J, Lin, H-Y, Han, G, Qu, X, Goode, EL, Chen, Z, Tsai, Y-Y, Cunningham, JM, Iversen, E, Ramus, S, Berchuck, A, Schildkraut, J, Monteiro, A, Gayther, S, Narod, SA, Sellers, TA, Pharoah, P, and Phelan, CM. "Abstract 4850: Variation in circadian rhythm genes influence epithelial ovarian cancer risk and invasiveness." April 15, 2013.

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Pharoah, PDP, Tsai, Y-Y, Ramus, SJ, Phelan, CM, Goode, EL, Lawrenson, K, Buckley, M, Fridley, BL, Tyrer, JP, Shen, H, Weber, R, Karevan, R, Larson, MC, Song, H, Tessier, DC, Bacot, F, Vincent, D, Cunningham, JM, Dennis, J, Dicks, E, Australian Cancer Study, , Australian Ovarian Cancer Study Group, , Aben, KK, Anton-Culver, H, Antonenkova, N, Armasu, SM, Baglietto, L, Bandera, EV, Beckmann, MW, Birrer, MJ, Bloom, G, Bogdanova, N, Brenton, JD, Brinton, LA, Brooks-Wilson, A, Brown, R, Butzow, R, Campbell, I, Carney, ME, Carvalho, RS, Chang-Claude, J, Chen, YA, Chen, Z, Chow, W-H, Cicek, MS, Coetzee, G, Cook, LS, Cramer, DW, Cybulski, C, Dansonka-Mieszkowska, A, Despierre, E, Doherty, JA, Dörk, T, du Bois, A, Dürst, M, Eccles, D, Edwards, R, Ekici, AB, Fasching, PA, Fenstermacher, D, Flanagan, J, Gao, Y-T, Garcia-Closas, M, Gentry-Maharaj, A, Giles, G, Gjyshi, A, Gore, M, Gronwald, J, Guo, Q, Halle, MK, Harter, P, Hein, A, Heitz, F, Hillemanns, P, Hoatlin, M, Høgdall, E, Høgdall, CK, Hosono, S, Jakubowska, A, Jensen, A, Kalli, KR, Karlan, BY, Kelemen, LE, Kiemeney, LA, Kjaer, SK, Konecny, GE, Krakstad, C, Kupryjanczyk, J, Lambrechts, D, Lambrechts, S, Le, ND, Lee, N, Lee, J, Leminen, A, Lim, BK, Lissowska, J, Lubiński, J, Lundvall, L, Lurie, G, Massuger, LFAG, Matsuo, K, McGuire, V, McLaughlin, JR, Menon, U, Modugno, F, Moysich, KB, Nakanishi, T, Narod, SA, Ness, RB, Nevanlinna, H, Nickels, S, Noushmehr, H, Odunsi, K, Olson, S, Orlow, I, Paul, J, Pejovic, T, Pelttari, LM, Permuth-Wey, J, Pike, MC, Poole, EM, Qu, X, Risch, HA, Rodriguez-Rodriguez, L, Rossing, MA, Rudolph, A, Runnebaum, I, Rzepecka, IK, Salvesen, HB, Schwaab, I, Severi, G, Shen, H, Shridhar, V, Shu, X-O, Sieh, W, Southey, MC, Spellman, P, Tajima, K, Teo, S-H, Terry, KL, Thompson, PJ, Timorek, A, Tworoger, SS, van Altena, AM, van den Berg, D, Vergote, I, Vierkant, RA, Vitonis, AF, Wang-Gohrke, S, Wentzensen, N, Whittemore, AS, Wik, E, Winterhoff, B, Woo, YL, Wu, AH, Yang, HP, Zheng, W, Ziogas, A, Zulkifli, F, Goodman, MT, Hall, P, Easton, DF, Pearce, CL, Berchuck, A, Chenevix-Trench, G, Iversen, E, Monteiro, ANA, Gayther, SA, Schildkraut, JM, and Sellers, TA. "GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer." Nature Genetics 45, no. 4 (April 2013): 362-370e2.

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Bojesen, SE, Pooley, KA, Johnatty, SE, Beesley, J, Michailidou, K, Tyrer, JP, Edwards, SL, Pickett, HA, Shen, HC, Smart, CE, Hillman, KM, Mai, PL, Lawrenson, K, Stutz, MD, Lu, Y, Karevan, R, Woods, N, Johnston, RL, French, JD, Chen, X, Weischer, M, Nielsen, SF, Maranian, MJ, Ghoussaini, M, Ahmed, S, Baynes, C, Bolla, MK, Wang, Q, Dennis, J, McGuffog, L, Barrowdale, D, Lee, A, Healey, S, Lush, M, Tessier, DC, Vincent, D, Bacot, F, Australian Cancer Study, , Australian Ovarian Cancer Study, , Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), , Gene Environment Interaction and Breast Cancer (GENICA), , Swedish Breast Cancer Study (SWE-BRCA), , Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), , Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE), , Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO), , Vergote, I, Lambrechts, S, Despierre, E, Risch, HA, González-Neira, A, Rossing, MA, Pita, G, Doherty, JA, Alvarez, N, Larson, MC, Fridley, BL, Schoof, N, Chang-Claude, J, Cicek, MS, Peto, J, Kalli, KR, Broeks, A, Armasu, SM, Schmidt, MK, Braaf, LM, Winterhoff, B, Nevanlinna, H, Konecny, GE, Lambrechts, D, Rogmann, L, Guénel, P, Teoman, A, Milne, RL, Garcia, JJ, Cox, A, Shridhar, V, Burwinkel, B, Marme, F, Hein, R, Sawyer, EJ, Haiman, CA, Wang-Gohrke, S, Andrulis, IL, Moysich, KB, Hopper, JL, Odunsi, K, Lindblom, A, Giles, GG, Brenner, H, Simard, J, Lurie, G, Fasching, PA, Carney, ME, Radice, P, Wilkens, LR, Swerdlow, A, Goodman, MT, Brauch, H, Garcia-Closas, M, Hillemanns, P, Winqvist, R, Dürst, M, Devilee, P, Runnebaum, I, Jakubowska, A, Lubinski, J, Mannermaa, A, Butzow, R, Bogdanova, NV, Dörk, T, Pelttari, LM, Zheng, W, Leminen, A, Anton-Culver, H, Bunker, CH, Kristensen, V, Ness, RB, Muir, K, Edwards, R, Meindl, A, Heitz, F, Matsuo, K, du Bois, A, Wu, AH, Harter, P, Teo, S-H, Schwaab, I, Shu, X-O, Blot, W, Hosono, S, Kang, D, Nakanishi, T, Hartman, M, Yatabe, Y, Hamann, U, Karlan, BY, Sangrajrang, S, Kjaer, SK, Gaborieau, V, Jensen, A, Eccles, D, Høgdall, E, Shen, C-Y, Brown, J, Woo, YL, Shah, M, Azmi, MAN, Luben, R, Omar, SZ, Czene, K, Vierkant, RA, Nordestgaard, BG, Flyger, H, Vachon, C, Olson, JE, Wang, X, Levine, DA, Rudolph, A, Weber, RP, Flesch-Janys, D, Iversen, E, Nickels, S, Schildkraut, JM, Silva, IDS, Cramer, DW, Gibson, L, Terry, KL, Fletcher, O, Vitonis, AF, van der Schoot, CE, Poole, EM, Hogervorst, FBL, Tworoger, SS, Liu, J, Bandera, EV, Li, J, Olson, SH, Humphreys, K, Orlow, I, Blomqvist, C, Rodriguez-Rodriguez, L, Aittomäki, K, Salvesen, HB, Muranen, TA, Wik, E, Brouwers, B, Krakstad, C, Wauters, E, Halle, MK, Wildiers, H, Kiemeney, LA, Mulot, C, Aben, KK, Laurent-Puig, P, Altena, AM, Truong, T, Massuger, LFAG, Benitez, J, Pejovic, T, Perez, JIA, Hoatlin, M, Zamora, MP, Cook, LS, Balasubramanian, SP, Kelemen, LE, Schneeweiss, A, Le, ND, Sohn, C, Brooks-Wilson, A, Tomlinson, I, Kerin, MJ, Miller, N, Cybulski, C, Henderson, BE, Menkiszak, J, Schumacher, F, Wentzensen, N, Le Marchand, L, Yang, HP, Mulligan, AM, Glendon, G, Engelholm, SA, Knight, JA, Høgdall, CK, Apicella, C, Gore, M, Tsimiklis, H, Song, H, Southey, MC, Jager, A, den Ouweland, AMW, Brown, R, Martens, JWM, Flanagan, JM, Kriege, M, Paul, J, Margolin, S, Siddiqui, N, Severi, G, Whittemore, AS, Baglietto, L, McGuire, V, Stegmaier, C, Sieh, W, Müller, H, Arndt, V, Labrèche, F, Gao, Y-T, Goldberg, MS, Yang, G, Dumont, M, McLaughlin, JR, Hartmann, A, Ekici, AB, Beckmann, MW, Phelan, CM, Lux, MP, Permuth-Wey, J, Peissel, B, Sellers, TA, Ficarazzi, F, Barile, M, Ziogas, A, Ashworth, A, Gentry-Maharaj, A, Jones, M, Ramus, SJ, Orr, N, Menon, U, Pearce, CL, Brüning, T, Pike, MC, Ko, Y-D, Lissowska, J, Figueroa, J, Kupryjanczyk, J, Chanock, SJ, Dansonka-Mieszkowska, A, Jukkola-Vuorinen, A, Rzepecka, IK, Pylkäs, K, Bidzinski, M, Kauppila, S, Hollestelle, A, Seynaeve, C, Tollenaar, RAEM, Durda, K, Jaworska, K, Hartikainen, JM, Kosma, V-M, Kataja, V, Antonenkova, NN, Long, J, Shrubsole, M, Deming-Halverson, S, Lophatananon, A, Siriwanarangsan, P, Stewart-Brown, S, Ditsch, N, Lichtner, P, Schmutzler, RK, Ito, H, Iwata, H, Tajima, K, Tseng, C-C, Stram, DO, van den Berg, D, Yip, CH, Ikram, MK, Teh, Y-C, Cai, H, Lu, W, Signorello, LB, Cai, Q, Noh, D-Y, Yoo, K-Y, Miao, H, Iau, PT-C, Teo, YY, McKay, J, Shapiro, C, Ademuyiwa, F, Fountzilas, G, Hsiung, C-N, Yu, J-C, Hou, M-F, Healey, CS, Luccarini, C, Peock, S, Stoppa-Lyonnet, D, Peterlongo, P, Rebbeck, TR, Piedmonte, M, Singer, CF, Friedman, E, Thomassen, M, Offit, K, Hansen, TVO, Neuhausen, SL, Szabo, CI, Blanco, I, Garber, J, Narod, SA, Weitzel, JN, Montagna, M, Olah, E, Godwin, AK, Yannoukakos, D, Goldgar, DE, Caldes, T, Imyanitov, EN, Tihomirova, L, Arun, BK, Campbell, I, Mensenkamp, AR, van Asperen, CJ, van Roozendaal, KEP, Meijers-Heijboer, H, Collée, JM, Oosterwijk, JC, Hooning, MJ, Rookus, MA, van der Luijt, RB, Os, TAM, Evans, DG, Frost, D, Fineberg, E, Barwell, J, Walker, L, Kennedy, MJ, Platte, R, Davidson, R, Ellis, SD, Cole, T, Bressac-de Paillerets, B, Buecher, B, Damiola, F, Faivre, L, Frenay, M, Sinilnikova, OM, Caron, O, Giraud, S, Mazoyer, S, Bonadona, V, Caux-Moncoutier, V, Toloczko-Grabarek, A, Gronwald, J, Byrski, T, Spurdle, AB, Bonanni, B, Zaffaroni, D, Giannini, G, Bernard, L, Dolcetti, R, Manoukian, S, Arnold, N, Engel, C, Deissler, H, Rhiem, K, Niederacher, D, Plendl, H, Sutter, C, Wappenschmidt, B, Borg, A, Melin, B, Rantala, J, Soller, M, Nathanson, KL, Domchek, SM, Rodriguez, GC, Salani, R, Kaulich, DG, Tea, M-K, Paluch, SS, Laitman, Y, Skytte, A-B, Kruse, TA, Jensen, UB, Robson, M, Gerdes, A-M, Ejlertsen, B, Foretova, L, Savage, SA, Lester, J, Soucy, P, Kuchenbaecker, KB, Olswold, C, Cunningham, JM, Slager, S, Pankratz, VS, Dicks, E, Lakhani, SR, Couch, FJ, Hall, P, Monteiro, ANA, Gayther, SA, Pharoah, PDP, Reddel, RR, Goode, EL, Greene, MH, Easton, DF, Berchuck, A, Antoniou, AC, Chenevix-Trench, G, and Dunning, AM. "Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer." Nature Genetics 45, no. 4 (April 2013): 371-384e2.

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Sieh, W, Salvador, S, McGuire, V, Weber, RP, Terry, KL, Rossing, MA, Risch, H, Wu, AH, Webb, PM, Moysich, K, Doherty, JA, Felberg, A, Miller, D, Jordan, SJ, Australian Cancer Study (Ovarian Cancer), , Australian Ovarian Cancer Study Group, , Goodman, MT, Lurie, G, Chang-Claude, J, Rudolph, A, Kjær, SK, Jensen, A, Høgdall, E, Bandera, EV, Olson, SH, King, MG, Rodriguez-Rodriguez, L, Kiemeney, LA, Marees, T, Massuger, LF, van Altena, AM, Ness, RB, Cramer, DW, Pike, MC, Pearce, CL, Berchuck, A, Schildkraut, JM, Whittemore, AS, and Ovarian Cancer Association Consortium, . "Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies." International Journal of Epidemiology 42, no. 2 (April 2013): 579-589.

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Sfakianos, GP, Iversen, ES, Whitaker, R, Akushevich, L, Schildkraut, JM, Murphy, SK, Marks, JR, and Berchuck, A. "Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues." Gynecol Oncol 129, no. 1 (April 2013): 159-164.

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