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Andrew Berchuck, MD

Andrew Berchuck, MD
James M. Ingram Professor of Gynecologic Oncology
Campus Mail: 25171 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: berch001@mc.duke.edu

Dr. Andrew Berchuck is Director of the Duke Division of Gynecologic Oncology and holds the James M. Ingram Distinguished Professorship. He is a practicing oncologist who is actively involved in the surgical and chemotherapy management of women with ovarian, endometrial and lower genital tract cancers. This includes minimally invasive laparoscopic surgical approaches. He also has developed a research program that focuses on the molecular-genetic alterations involved in malignant transformation of the ovarian and endometrial epithelium. He has published over 300 peer-reviewed papers in these areas. The objectives of his research include 1) identification of ovarian cancer susceptibility polymorphisms through a population-based case-control molecular epidemiologic study, and 2) use of genomic approaches  to elucidate the molecular heterogenetity of ovarian cancer. Thirty fellows and residents have worked in his lab, several of whom are now funded investigators. His research efforts have been recognized nationally and he has received awards for best oral presentation at the annual meetings of both the Society of Gynecologic Oncology and the International Gynecologic Cancer Society. Dr. Berchuck was awarded the Barbara Thomason Ovarian Cancer Research Professorship by the American Cancer Society in 2006. He has served as editor of several books in the field including Principles and Practice of Gynecologic Oncology. Dr. Berchuck also has a major commitment to national activities, and was President of the Society of Gynecologic Oncology in 2008. He served as chair of the scientific advisory committee of the Ovarian Cancer Research Fund (http://www.ocrf.org) in New York City. Finally, he is also head of the steering committee of the international Ovarian Cancer Association Consortium (OCAC), a group of 50 case-control studies that are working together to identify ovarian cancer susceptibility polymorphisms (www.srl.cam.ac.uk/consortia/ocac/index.html).

Education and Training

  • M.D., Case Western Reserve University, 1980

Research

Dr Berchuck is interested in the molecular pathogenesis of ovarian and endometrial cancer. 

View Publications

Selected Grants and Awards

Publications

Liu, G, Mukherjee, B, Lee, S, Lee, AW, Wu, AH, Bandera, EV, Jensen, A, Rossing, MA, Moysich, KB, Chang-Claude, J, Doherty, JA, Gentry-Maharaj, A, Kiemeney, L, Gayther, SA, Modugno, F, Massuger, L, Goode, EL, Fridley, BL, Terry, KL, Cramer, DW, Ramus, SJ, Anton-Culver, H, Ziogas, A, Tyrer, JP, Schildkraut, JM, Kjaer, SK, Webb, PM, Ness, RB, Menon, U, Berchuck, A, Pharoah, PD, Risch, H, Pearce, CL, and Ovarian Cancer Association Consortium, . "Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence." American Journal of Epidemiology 187, no. 2 (February 2018): 366-377.

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Johnson, OK, Berchuck, A, Secord, AA, and Peterson, AC. "Urinary diversion in the genitourinary cancer survivor." Gynecologic Oncology 148, no. 2 (February 2018): 414-421. (Review)

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Bailey, MH, Tokheim, C, Porta-Pardo, E, Sengupta, S, Bertrand, D, Weerasinghe, A, Colaprico, A, Wendl, MC, Kim, J, Reardon, B, Kwok-Shing Ng, P, Jeong, KJ, Cao, S, Wang, Z, Gao, J, Gao, Q, Wang, F, Liu, EM, Mularoni, L, Rubio-Perez, C, Nagarajan, N, Cortés-Ciriano, I, Zhou, DC, Liang, WW, Hess, JM, Yellapantula, VD, Tamborero, D, Gonzalez-Perez, A, Suphavilai, C, Ko, JY, Khurana, E, Park, PJ, Van Allen, EM, Liang, H, Caesar-Johnson, SJ, Demchok, JA, Felau, I, Kasapi, M, Ferguson, ML, Hutter, CM, Sofia, HJ, Tarnuzzer, R, Yang, L, Zenklusen, JC, Zhang, J, Chudamani, S, Liu, J, Lolla, L, Naresh, R, Pihl, T, Sun, Q, Wan, Y, Wu, Y, Cho, J, DeFreitas, T, Frazer, S, Gehlenborg, N, Getz, G, Heiman, DI, Lawrence, MS, Lin, P, Meier, S, Noble, MS, Saksena, G, Voet, D, Zhang, H, Bernard, B, Chambwe, N, Dhankani, V, Knijnenburg, T, Kramer, R, Leinonen, K, Liu, Y, Miller, M, Reynolds, S, Shmulevich, I, Thorsson, V, Zhang, W, Akbani, R, Broom, BM, Hegde, AM, Ju, Z, Kanchi, RS, Korkut, A, Li, J, Ling, S, Liu, W, Lu, Y, Mills, GB, Ng, KS, Rao, A, Ryan, M, Wang, J, Weinstein, JN, Abeshouse, A, and Armenia, J. "Comprehensive Characterization of Cancer Driver Genes and Mutations(Accepted)." Cell (January 1, 2018).

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Earp, M, Tyrer, JP, Winham, SJ, Lin, H-Y, Chornokur, G, Dennis, J, Aben, KKH, Anton-Culver, H, Antonenkova, N, Bandera, EV, Bean, YT, Beckmann, MW, Bjorge, L, Bogdanova, N, Brinton, LA, Brooks-Wilson, A, Bruinsma, F, Bunker, CH, Butzow, R, Campbell, IG, Carty, K, Chang-Claude, J, Cook, LS, Cramer, DW, Cunningham, JM, Cybulski, C, Dansonka-Mieszkowska, A, Despierre, E, Doherty, JA, Dörk, T, du Bois, A, Dürst, M, Easton, DF, Eccles, DM, Edwards, RP, Ekici, AB, Fasching, PA, Fridley, BL, Gentry-Maharaj, A, Giles, GG, Glasspool, R, Goodman, MT, Gronwald, J, Harter, P, Hein, A, Heitz, F, Hildebrandt, MAT, Hillemanns, P, Hogdall, CK, Høgdall, E, Hosono, S, Iversen, ES, Jakubowska, A, Jensen, A, Ji, B-T, Jung, AY, Karlan, BY, Kellar, M, Kiemeney, LA, Kiong Lim, B, Kjaer, SK, Krakstad, C, Kupryjanczyk, J, Lambrechts, D, Lambrechts, S, Le, ND, Lele, S, Lester, J, Levine, DA, Li, Z, Liang, D, Lissowska, J, Lu, K, Lubinski, J, Lundvall, L, Massuger, LFAG, Matsuo, K, McGuire, V, McLaughlin, JR, McNeish, I, Menon, U, Milne, RL, Modugno, F, Moysich, KB, Ness, RB, Nevanlinna, H, Odunsi, K, Olson, SH, Orlow, I, Orsulic, S, Paul, J, Pejovic, T, Pelttari, LM, Permuth, JB, Pike, MC, Poole, EM, Rosen, B, Rossing, MA, Rothstein, JH, Runnebaum, IB, Rzepecka, IK, Schernhammer, E, Schwaab, I, Shu, X-O, Shvetsov, YB, Siddiqui, N, Sieh, W, Song, H, Southey, MC, Spiewankiewicz, B, Sucheston-Campbell, L, Tangen, IL, Teo, S-H, Terry, KL, Thompson, PJ, Thomsen, L, Tworoger, SS, van Altena, AM, Vergote, I, Vestrheim Thomsen, LC, Vierkant, RA, Walsh, CS, Wang-Gohrke, S, Wentzensen, N, Whittemore, AS, Wicklund, KG, Wilkens, LR, Woo, Y-L, Wu, AH, Wu, X, Xiang, Y-B, Yang, H, Zheng, W, Ziogas, A, Lee, AW, Pearce, CL, Berchuck, A, Schildkraut, JM, Ramus, SJ, Monteiro, ANA, Narod, SA, Sellers, TA, Gayther, SA, Kelemen, LE, Chenevix-Trench, G, Risch, HA, Pharoah, PDP, Goode, EL, and Phelan, CM. "Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility." Plos One 13, no. 7 (January 2018): e0197561-null.

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Berchuck, A, Secord, AA, Moss, HA, and Havrilesky, LJ. "Maintenance Poly (ADP-ribose) Polymerase Inhibitor Therapy for Ovarian Cancer: Precision Oncology or One Size Fits All?." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 35, no. 36 (December 2017): 3999-4002.

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Moore, KN, Tritchler, D, Kaufman, KM, Lankes, H, Quinn, MCJ, Ovarian Cancer Association Consortium, , Van Le, L, Berchuck, A, Backes, FJ, Tewari, KS, Lee, RB, Kesterson, JP, Wenham, RM, Armstrong, DK, Krivak, TC, Bookman, MA, and Birrer, MJ. "Genome-wide association study evaluating single-nucleotide polymorphisms and outcomes in patients with advanced stage serous ovarian or primary peritoneal cancer: An NRG Oncology/Gynecologic Oncology Group study." Gynecologic Oncology 147, no. 2 (November 2017): 396-401.

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Bateman, NW, Dubil, EA, Wang, G, Hood, BL, Oliver, JM, Litzi, TA, Gist, GD, Mitchell, DA, Blanton, B, Phippen, NT, Tian, C, Zahn, CM, Cohn, DE, Havrilesky, LJ, Berchuck, A, Shriver, CD, Darcy, KM, Hamilton, CA, Conrads, TP, and Maxwell, GL. "Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients." Cancer 123, no. 20 (October 2017): 4004-4012.

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Glubb, DM, Johnatty, SE, Quinn, MCJ, O'Mara, TA, Tyrer, JP, Gao, B, Fasching, PA, Beckmann, MW, Lambrechts, D, Vergote, I, Velez Edwards, DR, Beeghly-Fadiel, A, Benitez, J, Garcia, MJ, Goodman, MT, Thompson, PJ, Dörk, T, Dürst, M, Modungo, F, Moysich, K, Heitz, F, du Bois, A, Pfisterer, J, Hillemanns, P, AGO Study Group, , Karlan, BY, Lester, J, Goode, EL, Cunningham, JM, Winham, SJ, Larson, MC, McCauley, BM, Kjær, SK, Jensen, A, Schildkraut, JM, Berchuck, A, Cramer, DW, Terry, KL, and Salvesen, HB et al. "Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci." Oncotarget 8, no. 39 (September 2017): 64670-64684.

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Janouskova, H, El Tekle, G, Bellini, E, Udeshi, ND, Rinaldi, A, Ulbricht, A, Bernasocchi, T, Civenni, G, Losa, M, Svinkina, T, Bielski, CM, Kryukov, GV, Cascione, L, Napoli, S, Enchev, RI, Mutch, DG, Carney, ME, Berchuck, A, Winterhoff, BJN, Broaddus, RR, Schraml, P, Moch, H, Bertoni, F, Catapano, CV, Peter, M, Carr, SA, Garraway, LA, Wild, PJ, and Theurillat, J-PP. "Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors." Nature Medicine 23, no. 9 (September 2017): 1046-1054.

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Skates, SJ, Greene, MH, Buys, SS, Mai, PL, Brown, P, Piedmonte, M, Rodriguez, G, Schorge, JO, Sherman, M, Daly, MB, Rutherford, T, Brewster, WR, O'Malley, DM, Partridge, E, Boggess, J, Drescher, CW, Isaacs, C, Berchuck, A, Domchek, S, Davidson, SA, Edwards, R, Elg, SA, Wakeley, K, Phillips, K-A, Armstrong, D, Horowitz, I, Fabian, CJ, Walker, J, Sluss, PM, Welch, W, Minasian, L, Horick, NK, Kasten, CH, Nayfield, S, Alberts, D, Finkelstein, DM, and Lu, KH. "Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 14 (July 2017): 3628-3637.

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