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Andrew Berchuck, MD

Andrew Berchuck, MD
James M. Ingram Professor of Gynecologic Oncology
Campus Mail: 25171 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: berch001@mc.duke.edu

Dr. Andrew Berchuck is Director of the Duke Division of Gynecologic Oncology and holds the James M. Ingram Distinguished Professorship. He is a practicing oncologist who is actively involved in the surgical and chemotherapy management of women with ovarian, endometrial and lower genital tract cancers. This includes minimally invasive laparoscopic surgical approaches. He also has developed a research program that focuses on the molecular-genetic alterations involved in malignant transformation of the ovarian and endometrial epithelium. He has published over 300 peer-reviewed papers in these areas. The objectives of his research include 1) identification of ovarian cancer susceptibility polymorphisms through a population-based case-control molecular epidemiologic study, and 2) use of genomic approaches  to elucidate the molecular heterogenetity of ovarian cancer. Thirty fellows and residents have worked in his lab, several of whom are now funded investigators. His research efforts have been recognized nationally and he has received awards for best oral presentation at the annual meetings of both the Society of Gynecologic Oncology and the International Gynecologic Cancer Society. Dr. Berchuck was awarded the Barbara Thomason Ovarian Cancer Research Professorship by the American Cancer Society in 2006. He has served as editor of several books in the field including Principles and Practice of Gynecologic Oncology. Dr. Berchuck also has a major commitment to national activities, and was President of the Society of Gynecologic Oncology in 2008. He served as chair of the scientific advisory committee of the Ovarian Cancer Research Fund (http://www.ocrf.org) in New York City. Finally, he is also head of the steering committee of the international Ovarian Cancer Association Consortium (OCAC), a group of 50 case-control studies that are working together to identify ovarian cancer susceptibility polymorphisms (www.srl.cam.ac.uk/consortia/ocac/index.html).

Education and Training

  • M.D., Case Western Reserve University, 1980

Research

Dr Berchuck is interested in the molecular pathogenesis of ovarian and endometrial cancer. 

View Publications

Selected Grants and Awards

Publications

Gaillard, S, Yi, J, Dumbauld, C, Ehrisman, J, Berchuck, A, and Weinhold, K. "Evaluating the Repertoire of Immune Checkpoint Markers Expressed Within Ovarian Cancers." JOURNAL OF WOMENS HEALTH 25, no. 9 (September 2016): 962-962.

Scholars@Duke

Kar, SP, Beesley, J, Amin Al Olama, A, Michailidou, K, Tyrer, J, Kote-Jarai, Z, Lawrenson, K, Lindstrom, S, Ramus, SJ, Thompson, DJ, ABCTB Investigators, , Kibel, AS, Dansonka-Mieszkowska, A, Michael, A, Dieffenbach, AK, Gentry-Maharaj, A, Whittemore, AS, Wolk, A, Monteiro, A, Peixoto, A, Kierzek, A, Cox, A, Rudolph, A, Gonzalez-Neira, A, Wu, AH, Lindblom, A, Swerdlow, A, AOCS Study Group & Australian Cancer Study (Ovarian Cancer), , APCB BioResource, , Ziogas, A, Ekici, AB, Burwinkel, B, Karlan, BY, Nordestgaard, BG, Blomqvist, C, Phelan, C, McLean, C, Pearce, CL, Vachon, C, Cybulski, C, Slavov, C, Stegmaier, C, Maier, C, Ambrosone, CB, Høgdall, CK, Teerlink, CC, Kang, D, Tessier, DC, Schaid, DJ, Stram, DO, Cramer, DW, Neal, DE, Eccles, D, Flesch-Janys, D, Edwards, DRV, Wokozorczyk, D, Levine, DA, Yannoukakos, D, Sawyer, EJ, Bandera, EV, Poole, EM, Goode, EL, Khusnutdinova, E, Høgdall, E, Song, F, Bruinsma, F, Heitz, F, Modugno, F, Hamdy, FC, Wiklund, F, Giles, GG, Olsson, H, Wildiers, H, Ulmer, H-U, Pandha, H, Risch, HA, Darabi, H, Salvesen, HB, Nevanlinna, H, Gronberg, H, Brenner, H, Brauch, H, Anton-Culver, H, Song, H, Lim, H-Y, McNeish, I, Campbell, I, Vergote, I, Gronwald, J, Lubiński, J, Stanford, JL, Benítez, J, Doherty, JA, Permuth, JB, Chang-Claude, J, Donovan, JL, Dennis, J, Schildkraut, JM, Schleutker, J, Hopper, JL, Kupryjanczyk, J, Park, JY, Figueroa, J, Clements, JA, Knight, JA, Peto, J, Cunningham, JM, Pow-Sang, J, Batra, J, Czene, K, Lu, KH, Herkommer, K, Khaw, K-T, kConFab Investigators, , Matsuo, K, Muir, K, Offitt, K, Chen, K, Moysich, KB, Aittomäki, K, Odunsi, K, Kiemeney, LA, Massuger, LFAG, Fitzgerald, LM, Cook, LS, Cannon-Albright, L, Hooning, MJ, Pike, MC, Bolla, MK, Luedeke, M, Teixeira, MR, Goodman, MT, Schmidt, MK, Riggan, M, Aly, M, Rossing, MA, Beckmann, MW, Moisse, M, Sanderson, M, Southey, MC, Jones, M, Lush, M, Hildebrandt, MAT, Hou, M-F, Schoemaker, MJ, Garcia-Closas, M, Bogdanova, N, Rahman, N, NBCS Investigators, , Le, ND, Orr, N, Wentzensen, N, Pashayan, N, Peterlongo, P, Guénel, P, Brennan, P, Paulo, P, Webb, PM, Broberg, P, Fasching, PA, Devilee, P, Wang, Q, Cai, Q, Li, Q, Kaneva, R, Butzow, R, Kopperud, RK, Schmutzler, RK, Stephenson, RA, MacInnis, RJ, Hoover, RN, Winqvist, R, Ness, R, Milne, RL, Travis, RC, Benlloch, S, Olson, SH, McDonnell, SK, Tworoger, SS, Maia, S, Berndt, S, Lee, SC, Teo, S-H, Thibodeau, SN, Bojesen, SE, Gapstur, SM, Kjær, SK, Pejovic, T, Tammela, TLJ, GENICA Network, , PRACTICAL consortium, , Dörk, T, Brüning, T, Wahlfors, T, Key, TJ, Edwards, TL, Menon, U, Hamann, U, Mitev, V, Kosma, V-M, Setiawan, VW, Kristensen, V, Arndt, V, Vogel, W, Zheng, W, Sieh, W, Blot, WJ, Kluzniak, W, Shu, X-O, Gao, Y-T, Schumacher, F, Freedman, ML, Berchuck, A, Dunning, AM, Simard, J, Haiman, CA, Spurdle, A, Sellers, TA, Hunter, DJ, Henderson, BE, Kraft, P, Chanock, SJ, Couch, FJ, Hall, P, Gayther, SA, Easton, DF, Chenevix-Trench, G, Eeles, R, Pharoah, PDP, and Lambrechts, D. "Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types." Cancer Discovery 6, no. 9 (September 2016): 1052-1067.

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Lee, AW, Ness, RB, Roman, LD, Terry, KL, Schildkraut, JM, Chang-Claude, J, Doherty, JA, Menon, U, Cramer, DW, Gayther, SA, Risch, H, Gentry-Maharaj, A, Goodman, MT, Modugno, F, Eilber, U, Moysich, KB, Berchuck, A, Rossing, MA, Jensen, A, Wicklund, KG, Cushing-Haugen, KL, Hogdall, E, Rudolph, A, Thompson, PJ, Wilkens, LR, Kjaer, SK, Carney, ME, Stram, DO, Ramus, SJ, Wu, AH, Pike, MC, and Pearce, CL. "Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk." Obstetrical & Gynecological Survey 71, no. 8 (August 2016): 470-471.

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Permuth, JB, Pirie, A, Ann Chen, Y, Lin, H-Y, Reid, BM, Chen, Z, Monteiro, A, Dennis, J, Mendoza-Fandino, G, AOCS Study Group, , Australian Cancer Study (Ovarian Cancer), , Anton-Culver, H, Bandera, EV, Bisogna, M, Brinton, L, Brooks-Wilson, A, Carney, ME, Chenevix-Trench, G, Cook, LS, Cramer, DW, Cunningham, JM, Cybulski, C, D'Aloisio, AA, Anne Doherty, J, Earp, M, Edwards, RP, Fridley, BL, Gayther, SA, Gentry-Maharaj, A, Goodman, MT, Gronwald, J, Hogdall, E, Iversen, ES, Jakubowska, A, Jensen, A, Karlan, BY, Kelemen, LE, Kjaer, SK, Kraft, P, Le, ND, Levine, DA, Lissowska, J, Lubinski, J, Matsuo, K, Menon, U, Modugno, R, Moysich, KB, Nakanishi, T, Ness, RB, Olson, S, Orlow, I, Pearce, CL, Pejovic, T, Poole, EM, Ramus, SJ, Anne Rossing, M, Sandler, DP, Shu, X-O, Song, H, Taylor, JA, Teo, S-H, Terry, KL, Thompson, PJ, Tworoger, SS, Webb, PM, Wentzensen, N, Wilkens, LR, Winham, S, Woo, Y-L, Wu, AH, Yang, H, Zheng, W, Ziogas, A, Phelan, CM, Schildkraut, JM, Berchuck, A, Goode, EL, Pharoah, PDP, Sellers, TA, and Ovarian Cancer Association Consortium, . "Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk." Human Molecular Genetics 25, no. 16 (August 2016): 3600-3612.

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Ehrisman, J, Secord, AA, Berchuck, A, Lee, PS, Di Santo, N, Lopez-Acevedo, M, Broadwater, G, Valea, FA, and Havrilesky, LJ. "Performance of sentinel lymph node biopsy in high-risk endometrial cancer." Gynecologic oncology reports 17 (August 2016): 69-71.

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Doherty, JA, Greene, CS, Rudd, JE, Tafe, LJ, Alberg, AJ, Bandera, EV, Barnholtz-Sloan, J, Bondy, M, Cote, ML, Funkhouser, E, Moorman, PG, Peters, ES, Schwartz, AG, Terry, P, Bentley, R, Berchuck, A, Marks, JR, and Schildkraut, JM. "Abstract 3407: Gene expression subtypes of high grade serous ovarian cancer in African American women." July 15, 2016.

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Lee, AW, Bomkamp, A, Bandera, EV, Jensen, A, Ramus, SJ, Goodman, MT, Rossing, MA, Modugno, F, Moysich, KB, Chang-Claude, J, Rudolph, A, Gentry-Maharaj, A, Terry, KL, Gayther, SA, Cramer, DW, Doherty, JA, Schildkraut, JM, Kjaer, SK, Ness, RB, Menon, U, Berchuck, A, Mukherjee, B, Roman, L, Pharoah, PD, Chenevix-Trench, G, Wu, AH, Pike, MC, and Pearce, CL. "Abstract 797: A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer." July 15, 2016.

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Cuellar-Partida, G, Lu, Y, Dixon, SC, Australian Ovarian Cancer Study, , Fasching, PA, Hein, A, Burghaus, S, Beckmann, MW, Lambrechts, D, Van Nieuwenhuysen, E, Vergote, I, Vanderstichele, A, Doherty, JA, Rossing, MA, Chang-Claude, J, Rudolph, A, Wang-Gohrke, S, Goodman, MT, Bogdanova, N, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, IB, Antonenkova, N, Butzow, R, Leminen, A, Nevanlinna, H, Pelttari, LM, Edwards, RP, Kelley, JL, Modugno, F, Moysich, KB, Ness, RB, Cannioto, R, Høgdall, E, Høgdall, C, Jensen, A, Giles, GG, Bruinsma, F, Kjaer, SK, Hildebrandt, MAT, Liang, D, Lu, KH, Wu, X, Bisogna, M, Dao, F, Levine, DA, Cramer, DW, Terry, KL, Tworoger, SS, Stampfer, M, Missmer, S, Bjorge, L, Salvesen, HB, Kopperud, RK, Bischof, K, Aben, KKH, Kiemeney, LA, Massuger, LFAG, Brooks-Wilson, A, Olson, SH, McGuire, V, Rothstein, JH, Sieh, W, Whittemore, AS, Cook, LS, Le, ND, Blake Gilks, C, Gronwald, J, Jakubowska, A, Lubiński, J, Kluz, T, Song, H, Tyrer, JP, Wentzensen, N, Brinton, L, Trabert, B, Lissowska, J, McLaughlin, JR, Narod, SA, Phelan, C, Anton-Culver, H, Ziogas, A, Eccles, D, Campbell, I, Gayther, SA, Gentry-Maharaj, A, Menon, U, Ramus, SJ, Wu, AH, Dansonka-Mieszkowska, A, Kupryjanczyk, J, Timorek, A, Szafron, L, Cunningham, JM, Fridley, BL, Winham, SJ, Bandera, EV, Poole, EM, Morgan, TK, Goode, EL, Schildkraut, JM, Pearce, CL, Berchuck, A, Pharoah, PDP, Webb, PM, Chenevix-Trench, G, Risch, HA, and MacGregor, S. "Assessing the genetic architecture of epithelial ovarian cancer histological subtypes." Human Genetics 135, no. 7 (July 2016): 741-756.

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Cannioto, R, LaMonte, MJ, Risch, HA, Hong, C-C, Sucheston-Campbell, LE, Eng, KH, Brian Szender, J, Chang-Claude, J, Schmalfeldt, B, Klapdor, R, Gower, E, Minlikeeva, AN, Zirpoli, GR, Bandera, EV, Berchuck, A, Cramer, D, Doherty, JA, Edwards, RP, Fridley, BL, Goode, EL, Goodman, MT, Hogdall, E, Hosono, S, Jensen, A, Jordan, S, Australian Ovarian Cancer Study Group, , Kjaer, SK, Matsuo, K, Ness, RB, Olsen, CM, Olson, SH, Leigh Pearce, C, Pike, MC, Anne Rossing, M, Szamreta, EA, and Thompson, PJ et al. "Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 25, no. 7 (July 2016): 1114-1124. (Review)

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Cannioto, RA, LaMonte, MJ, Kelemen, LE, Risch, HA, Eng, KH, Minlikeeva, AN, Hong, C-C, Szender, JB, Sucheston-Campbell, L, Joseph, JM, Berchuck, A, Chang-Claude, J, Cramer, DW, DeFazio, A, Diergaarde, B, Dörk, T, Doherty, JA, Edwards, RP, Fridley, BL, Friel, G, Goode, EL, Goodman, MT, Hillemanns, P, Hogdall, E, Hosono, S, Kelley, JL, Kjaer, SK, Klapdor, R, Matsuo, K, Odunsi, K, Nagle, CM, Olsen, CM, Paddock, LE, Pearce, CL, Pike, MC, Rossing, MA, Schmalfeldt, B, Segal, BH, and Szamreta, EA et al. "Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium." British journal of cancer 115, no. 1 (June 14, 2016): 95-101. (letter)

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