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Andrew Berchuck, MD

Andrew Berchuck, MD
James M. Ingram Professor of Gynecologic Oncology
Campus Mail: 25171 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: berch001@mc.duke.edu

Dr. Andrew Berchuck is Director of the Duke Division of Gynecologic Oncology and holds the James M. Ingram Distinguished Professorship. He is a practicing oncologist who is actively involved in the surgical and chemotherapy management of women with ovarian, endometrial and lower genital tract cancers. This includes minimally invasive laparoscopic surgical approaches. He also has developed a research program that focuses on the molecular-genetic alterations involved in malignant transformation of the ovarian and endometrial epithelium. He has published over 300 peer-reviewed papers in these areas. The objectives of his research include 1) identification of ovarian cancer susceptibility polymorphisms through a population-based case-control molecular epidemiologic study, and 2) use of genomic approaches  to elucidate the molecular heterogenetity of ovarian cancer. Thirty fellows and residents have worked in his lab, several of whom are now funded investigators. His research efforts have been recognized nationally and he has received awards for best oral presentation at the annual meetings of both the Society of Gynecologic Oncology and the International Gynecologic Cancer Society. Dr. Berchuck was awarded the Barbara Thomason Ovarian Cancer Research Professorship by the American Cancer Society in 2006. He has served as editor of several books in the field including Principles and Practice of Gynecologic Oncology. Dr. Berchuck also has a major commitment to national activities, and was President of the Society of Gynecologic Oncology in 2008. He served as chair of the scientific advisory committee of the Ovarian Cancer Research Fund (http://www.ocrf.org) in New York City. Finally, he is also head of the steering committee of the international Ovarian Cancer Association Consortium (OCAC), a group of 50 case-control studies that are working together to identify ovarian cancer susceptibility polymorphisms (www.srl.cam.ac.uk/consortia/ocac/index.html).

Education and Training

  • M.D., Case Western Reserve University, 1980

Research

Dr Berchuck is interested in the molecular pathogenesis of ovarian and endometrial cancer. 

View Publications

Publications

Ignar-Trowbridge, D, Risinger, JI, Dent, GA, Kohler, M, Berchuck, A, McLachlan, JA, and Boyd, J. "Mutations of the Ki-ras oncogene in endometrial carcinoma." Am J Obstet Gynecol 167, no. 1 (July 1992): 227-232.

Scholars@Duke

Kerns, BJ, Jordan, PA, Moore, MB, Humphrey, PA, Berchuck, A, Kohler, MF, Bast, RC, Iglehart, JD, and Marks, JR. "p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry." J Histochem Cytochem 40, no. 7 (July 1992): 1047-1051.

Full Text

Soper, JT, Berchuck, A, Dodge, R, and Clarke-Pearson, DL. "Adjuvant therapy with intraperitoneal chromic phosphate (32P) in women with early ovarian carcinoma after comprehensive surgical staging." Obstet Gynecol 79, no. 6 (June 1992): 993-997.

Scholars@Duke

O'Briant, K, Chrysson, N, Hunter, V, Tyson, F, Tanner, M, Daly, L, George, SL, Berchuck, A, Soper, J, and Fowler, W. "Ha-ras polymorphisms in epithelial ovarian cancer." Gynecol Oncol 45, no. 3 (June 1992): 299-302.

Scholars@Duke

Bast, RC, Jacobs, I, and Berchuck, A. "Malignant transformation of ovarian epithelium." J Natl Cancer Inst 84, no. 8 (April 15, 1992): 556-558.

Scholars@Duke

Kohler, MF, Berchuck, A, Davidoff, AM, Humphrey, PA, Dodge, RK, Iglehart, JD, Soper, JT, Clarke-Pearson, DL, Bast, RC, and Marks, JR. "Overexpression and mutation of p53 in endometrial carcinoma." Cancer Res 52, no. 6 (March 15, 1992): 1622-1627.

Scholars@Duke

Berchuck, A, Boente, MP, and Bast, RC. "The use of tumor markers in the management of patients with gynecologic carcinomas." Clin Obstet Gynecol 35, no. 1 (March 1992): 45-54. (Review)

Scholars@Duke

Berchuck, A, Rodriguez, G, Olt, G, Whitaker, R, Boente, MP, Arrick, BA, Clarke-Pearson, DL, and Bast, RC. "Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta." Am J Obstet Gynecol 166, no. 2 (February 1992): 676-684.

Scholars@Duke

BAST, RC, BOYER, CM, BERCHUCK, A, XU, FJ, WU, S, LIDOR, Y, MAIER, LA, CREWS, JR, ROSSE, M, VREDENBURGH, JJ, SHPALL, EJ, and PETERS, WP. "NEW STRATEGIES FOR THE MANAGEMENT OF OVARIAN AND BREAST-CANCER BASED ON BIOLOGY AND PHARMACOLOGY." 1992.

Scholars@Duke

Berchuck, A, Boente, MP, Kerns, BJ, Kinney, RB, Soper, JT, Clarke-Pearson, DL, Bast, RC, and Bacus, SS. "Ploidy analysis of epithelial ovarian cancers using image cytometry." Gynecol Oncol 44, no. 1 (January 1992): 61-65.

Scholars@Duke

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