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Andrew Berchuck, MD

Andrew Berchuck, MD
James M. Ingram Professor of Gynecologic Oncology
Campus Mail: 25171 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: berch001@mc.duke.edu

Dr. Andrew Berchuck is Director of the Duke Division of Gynecologic Oncology and holds the James M. Ingram Distinguished Professorship. He is a practicing oncologist who is actively involved in the surgical and chemotherapy management of women with ovarian, endometrial and lower genital tract cancers. This includes minimally invasive laparoscopic surgical approaches. He also has developed a research program that focuses on the molecular-genetic alterations involved in malignant transformation of the ovarian and endometrial epithelium. He has published over 300 peer-reviewed papers in these areas. The objectives of his research include 1) identification of ovarian cancer susceptibility polymorphisms through a population-based case-control molecular epidemiologic study, and 2) use of genomic approaches  to elucidate the molecular heterogenetity of ovarian cancer. Thirty fellows and residents have worked in his lab, several of whom are now funded investigators. His research efforts have been recognized nationally and he has received awards for best oral presentation at the annual meetings of both the Society of Gynecologic Oncology and the International Gynecologic Cancer Society. Dr. Berchuck was awarded the Barbara Thomason Ovarian Cancer Research Professorship by the American Cancer Society in 2006. He has served as editor of several books in the field including Principles and Practice of Gynecologic Oncology. Dr. Berchuck also has a major commitment to national activities, and was President of the Society of Gynecologic Oncology in 2008. He served as chair of the scientific advisory committee of the Ovarian Cancer Research Fund (http://www.ocrf.org) in New York City. Finally, he is also head of the steering committee of the international Ovarian Cancer Association Consortium (OCAC), a group of 50 case-control studies that are working together to identify ovarian cancer susceptibility polymorphisms (www.srl.cam.ac.uk/consortia/ocac/index.html).

Education and Training

  • M.D., Case Western Reserve University, 1980

Research

Dr Berchuck is interested in the molecular pathogenesis of ovarian and endometrial cancer. 

View Publications

Selected Grants and Awards

Publications

Dixon, SC, Nagle, CM, Thrift, AP, Pharoah, PD, Pearce, CL, Zheng, W, Painter, JN, AOCS Group & Australian Cancer Study (Ovarian Cancer), , Chenevix-Trench, G, Fasching, PA, Beckmann, MW, Lambrechts, D, Vergote, I, Lambrechts, S, Van Nieuwenhuysen, E, Rossing, MA, Doherty, JA, Wicklund, KG, Chang-Claude, J, Rudolph, A, Moysich, KB, Odunsi, K, Goodman, MT, Wilkens, LR, Thompson, PJ, Shvetsov, YB, Dörk, T, Park-Simon, T-W, Hillemanns, P, Bogdanova, N, Butzow, R, Nevanlinna, H, and Pelttari, LM et al. "Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study." International journal of epidemiology 45, no. 3 (June 2016): 884-895.

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Erondu, CO, Alberg, AJ, Bandera, EV, Barnholtz-Sloan, J, Bondy, M, Cote, ML, Funkhouser, E, Peters, E, Schwartz, AG, Terry, PD, Wallace, K, Akushevich, L, Wang, F, Crankshaw, S, Berchuck, A, Schildkraut, JM, and Moorman, PG. "The Association Between Body Mass Index and Presenting Symptoms in African American Women with Ovarian Cancer." Journal of women's health (2002) 25, no. 6 (June 2016): 571-578.

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Witkowski, L, Goudie, C, Ramos, P, Boshari, T, Brunet, J-S, Karnezis, AN, Longy, M, Knost, JA, Saloustros, E, McCluggage, WG, Stewart, CJR, Hendricks, WPD, Cunliffe, H, Huntsman, DG, Pautier, P, Levine, DA, Trent, JM, Berchuck, A, Hasselblatt, M, and Foulkes, WD. "The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type." Gynecologic oncology 141, no. 3 (June 2016): 454-460.

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"What Women and Their Physicians Need to Know About the UKCTOCS Study and Ovarian Cancer Screening." American family physician 93, no. 11 (June 2016): 903-904.

Scholars@Duke

Usset, JL, Raghavan, R, Tyrer, JP, McGuire, V, Sieh, W, Webb, P, Chang-Claude, J, Rudolph, A, Anton-Culver, H, Berchuck, A, Brinton, L, Cunningham, JM, DeFazio, A, Doherty, JA, Edwards, RP, Gayther, SA, Gentry-Maharaj, A, Goodman, MT, Høgdall, E, Jensen, A, Johnatty, SE, Kiemeney, LA, Kjaer, SK, Larson, MC, Lurie, G, Massuger, L, Menon, U, Modugno, F, Moysich, KB, Ness, RB, Pike, MC, Ramus, SJ, Rossing, MA, Rothstein, J, Song, H, Thompson, PJ, van den Berg, DJ, Vierkant, RA, Wang-Gohrke, S, Wentzensen, N, Whittemore, AS, Wilkens, LR, Wu, AH, Yang, H, Pearce, CL, Schildkraut, JM, Pharoah, P, Goode, EL, Fridley, BL, and Ovarian Cancer Association Consortium and the Australian Cancer Study, . "Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 25, no. 5 (May 2016): 780-790.

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Lee, AW, Ness, RB, Roman, LD, Terry, KL, Schildkraut, JM, Chang-Claude, J, Doherty, JA, Menon, U, Cramer, DW, Gayther, SA, Risch, H, Gentry-Maharaj, A, Goodman, MT, Modugno, F, Eilber, U, Moysich, KB, Berchuck, A, Rossing, MA, Jensen, A, Wicklund, KG, Cushing-Haugen, KL, Hogdall, E, Rudolph, A, Thompson, PJ, Wilkens, LR, Kjaer, SK, Carney, ME, Stram, DO, Ramus, SJ, Wu, AH, Pike, MC, Pearce, CL, and Ovarian Cancer Association Consortium, . "Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk." Obstetrics and Gynecology 127, no. 5 (May 2016): 828-836.

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Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2, , Hollestelle, A, van der Baan, FH, Berchuck, A, Johnatty, SE, Aben, KK, Agnarsson, BA, Aittomäki, K, Alducci, E, Andrulis, IL, Anton-Culver, H, Antonenkova, NN, Antoniou, AC, Apicella, C, Arndt, V, Arnold, N, Arun, BK, Arver, B, Ashworth, A, Australian Ovarian Cancer Study Group, , Baglietto, L, Balleine, R, Bandera, EV, Barrowdale, D, Bean, YT, Beckmann, L, Beckmann, MW, Benitez, J, Berger, A, Berger, R, Beuselinck, B, Bisogna, M, Bjorge, L, Blomqvist, C, Bogdanova, NV, Bojesen, A, Bojesen, SE, Bolla, MK, Bonanni, B, Brand, JS, Brauch, H, Breast Cancer Family Register, , Brenner, H, Brinton, L, Brooks-Wilson, A, Bruinsma, F, Brunet, J, Brüning, T, Budzilowska, A, Bunker, CH, Burwinkel, B, Butzow, R, Buys, SS, Caligo, MA, Campbell, I, Carter, J, Chang-Claude, J, Chanock, SJ, Claes, KBM, Collée, JM, Cook, LS, Couch, FJ, Cox, A, Cramer, D, Cross, SS, Cunningham, JM, Cybulski, C, Czene, K, Damiola, F, Dansonka-Mieszkowska, A, Darabi, H, de la Hoya, M, deFazio, A, Dennis, J, Devilee, P, Dicks, EM, Diez, O, Doherty, JA, Domchek, SM, Dorfling, CM, Dörk, T, Silva, IDS, du Bois, A, Dumont, M, Dunning, AM, Duran, M, Easton, DF, Eccles, D, Edwards, RP, Ehrencrona, H, Ejlertsen, B, Ekici, AB, Ellis, SD, EMBRACE, , Engel, C, Eriksson, M, Fasching, PA, Feliubadalo, L, Figueroa, J, Flesch-Janys, D, Fletcher, O, Fontaine, A, Fortuzzi, S, Fostira, F, Fridley, BL, Friebel, T, Friedman, E, Friel, G, Frost, D, Garber, J, García-Closas, M, Gayther, SA, GEMO Study Collaborators, , GENICA Network, , Gentry-Maharaj, A, Gerdes, A-M, Giles, GG, Glasspool, R, Glendon, G, Godwin, AK, Goodman, MT, Gore, M, Greene, MH, Grip, M, Gronwald, J, Gschwantler Kaulich, D, Guénel, P, Guzman, SR, Haeberle, L, Haiman, CA, Hall, P, Halverson, SL, Hamann, U, Hansen, TVO, Harter, P, Hartikainen, JM, Healey, S, HEBON, , Hein, A, Heitz, F, Henderson, BE, Herzog, J, T Hildebrandt, MA, Høgdall, CK, Høgdall, E, Hogervorst, FBL, Hopper, JL, Humphreys, K, Huzarski, T, Imyanitov, EN, Isaacs, C, Jakubowska, A, Janavicius, R, Jaworska, K, Jensen, A, Jensen, UB, Johnson, N, Jukkola-Vuorinen, A, Kabisch, M, Karlan, BY, Kataja, V, Kauff, N, KConFab Investigators, , Kelemen, LE, Kerin, MJ, Kiemeney, LA, Kjaer, SK, Knight, JA, Knol-Bout, JP, Konstantopoulou, I, Kosma, V-M, Krakstad, C, Kristensen, V, Kuchenbaecker, KB, Kupryjanczyk, J, Laitman, Y, Lambrechts, D, Lambrechts, S, Larson, MC, Lasa, A, Laurent-Puig, P, Lazaro, C, Le, ND, Le Marchand, L, Leminen, A, Lester, J, Levine, DA, Li, J, Liang, D, Lindblom, A, Lindor, N, Lissowska, J, Long, J, Lu, KH, Lubinski, J, Lundvall, L, Lurie, G, Mai, PL, Mannermaa, A, Margolin, S, Mariette, F, Marme, F, Martens, JWM, Massuger, LFAG, Maugard, C, Mazoyer, S, McGuffog, L, McGuire, V, McLean, C, McNeish, I, Meindl, A, Menegaux, F, Menéndez, P, Menkiszak, J, Menon, U, Mensenkamp, AR, Miller, N, Milne, RL, Modugno, F, Montagna, M, Moysich, KB, Müller, H, Mulligan, AM, Muranen, TA, Narod, SA, Nathanson, KL, Ness, RB, Neuhausen, SL, Nevanlinna, H, Neven, P, Nielsen, FC, Nielsen, SF, Nordestgaard, BG, Nussbaum, RL, Odunsi, K, Offit, K, Olah, E, Olopade, OI, Olson, JE, Olson, SH, Oosterwijk, JC, Orlow, I, Orr, N, Orsulic, S, Osorio, A, Ottini, L, Paul, J, Pearce, CL, Pedersen, IS, Peissel, B, Pejovic, T, Pelttari, LM, Perkins, J, Permuth-Wey, J, Peterlongo, P, Peto, J, Phelan, CM, Phillips, K-A, Piedmonte, M, Pike, MC, Platte, R, Plisiecka-Halasa, J, Poole, EM, Poppe, B, Pylkäs, K, Radice, P, Ramus, SJ, Rebbeck, TR, Reed, MWR, Rennert, G, Risch, HA, Robson, M, Rodriguez, GC, Romero, A, Rossing, MA, Rothstein, JH, Rudolph, A, Runnebaum, I, Salani, R, Salvesen, HB, Sawyer, EJ, Schildkraut, JM, Schmidt, MK, Schmutzler, RK, Schneeweiss, A, Schoemaker, MJ, Schrauder, MG, Schumacher, F, Schwaab, I, Scuvera, G, Sellers, TA, Severi, G, Seynaeve, CM, Shah, M, Shrubsole, M, Siddiqui, N, Sieh, W, Simard, J, Singer, CF, Sinilnikova, OM, Smeets, D, Sohn, C, Soller, M, Song, H, Soucy, P, Southey, MC, Stegmaier, C, Stoppa-Lyonnet, D, Sucheston, L, SWE-BRCA, , Swerdlow, A, Tangen, IL, Tea, M-K, Teixeira, MR, Terry, KL, Terry, MB, Thomassen, M, Thompson, PJ, Tihomirova, L, Tischkowitz, M, Toland, AE, Tollenaar, RAEM, Tomlinson, I, Torres, D, Truong, T, Tsimiklis, H, Tung, N, Tworoger, SS, Tyrer, JP, Vachon, CM, Van 't Veer, LJ, van Altena, AM, Van Asperen, CJ, van den Berg, D, van den Ouweland, AMW, van Doorn, HC, Van Nieuwenhuysen, E, van Rensburg, EJ, Vergote, I, Verhoef, S, Vierkant, RA, Vijai, J, Vitonis, AF, von Wachenfeldt, A, Walsh, C, Wang, Q, Wang-Gohrke, S, Wappenschmidt, B, Weischer, M, Weitzel, JN, Weltens, C, Wentzensen, N, Whittemore, AS, Wilkens, LR, Winqvist, R, Wu, AH, Wu, X, Yang, HP, Zaffaroni, D, Pilar Zamora, M, Zheng, W, Ziogas, A, Chenevix-Trench, G, Pharoah, PDP, Rookus, MA, Hooning, MJ, and Goode, EL. "No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer." Gynecologic Oncology 141, no. 2 (May 2016): 386-401. (Review)

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Præstegaard, C, Kjaer, SK, Nielsen, TSS, Jensen, SM, Webb, PM, Nagle, CM, Høgdall, E, Risch, HA, Rossing, MA, Doherty, JA, Wicklund, KG, Goodman, MT, Modugno, F, Moysich, K, Ness, RB, Edwards, RP, Goode, EL, Winham, SJ, Fridley, BL, Cramer, DW, Terry, KL, Schildkraut, JM, Berchuck, A, Bandera, EV, Paddock, L, Kiemeney, LA, Massuger, LF, Wentzensen, N, Pharoah, P, Song, H, Whittemore, AS, McGuire, V, Sieh, W, Rothstein, J, Anton-Culver, H, Ziogas, A, Menon, U, Gayther, SA, Ramus, SJ, Gentry-Maharaj, A, Wu, AH, Pearce, CL, Pike, MC, Lee, AW, Chang-Claude, J, Jensen, A, and Ovarian Cancer Association Consortium, . "The association between socioeconomic status and tumour stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies." Cancer Epidemiology 41 (April 2016): 71-79.

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Winham, SJ, Pirie, A, Chen, YA, Larson, MC, Fogarty, ZC, Earp, MA, Anton-Culver, H, Bandera, EV, Cramer, D, Doherty, JA, Goodman, MT, Gronwald, J, Karlan, BY, Kjaer, SK, Levine, DA, Menon, U, Ness, RB, Pearce, CL, Pejovic, T, Rossing, MA, Wentzensen, N, Bean, YT, Bisogna, M, Brinton, LA, Carney, ME, Cunningham, JM, Cybulski, C, deFazio, A, Dicks, EM, Edwards, RP, Gayther, SA, Gentry-Maharaj, A, Gore, M, Iversen, ES, Jensen, A, Johnatty, SE, Lester, J, Lin, H-Y, Lissowska, J, Lubinski, J, Menkiszak, J, Modugno, F, Moysich, KB, Orlow, I, Pike, MC, Ramus, SJ, Song, H, Terry, KL, Thompson, PJ, Tyrer, JP, van den Berg, DJ, Vierkant, RA, Vitonis, AF, Walsh, C, Wilkens, LR, Wu, AH, Yang, H, Ziogas, A, Berchuck, A, Chenevix-Trench, G, Schildkraut, JM, Permuth-Wey, J, Phelan, CM, Pharoah, PDP, Fridley, BL, Sellers, TA, Goode, EL, and Australian Ovarian Cancer Study Group, . "Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 25, no. 3 (March 2016): 446-454.

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Brancu, M, Mann-Wrobel, M, Beckham, JC, Wagner, HR, Elliott, A, Robbins, AT, Wong, M, Berchuck, AE, and Runnals, JJ. "Subthreshold posttraumatic stress disorder: A meta-analytic review of DSM-IV prevalence and a proposed DSM-5 approach to measurement." Psychological Trauma : Theory, Research, Practice and Policy 8, no. 2 (March 2016): 222-232.

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