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Angeles Alvarez Secord, MD

Angeles Secord, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: secor002@mc.duke.edu

My primary research interest has focused on angiogenesis, molecular signatures, clinical trial development, and ovarian cancer. My fundamental goal is to develop a strong translational research program at Duke University in the Gynecologic Oncology Division where knowledge we glean from our basic science research can be incorporated into our clinical trial program. Specifically on anti-angiogenic therapy and molecular tumor signatures to direct therapy in patients with ovarian cancer to determine if a strategy that incorporates both clinical and genomic information can improve clinical outcome, minimize unnecessary toxicity, and impact positively on quality of life.
In addition I am interested in robotic-assisted laparoscopic surgery for women with endometrial, ovarian, and cervical cancers as well as for benign gynecologic conditions.

Education and Training

  • Resident, Obstetrics & Gynecology, Duke University, 1994 - 1998
  • M.D., University of Washington, 1994

Certifications

  • Duke University Medical Center, Masters of Health Sciences in Clinical Research, 2005-2011

Research

Dr. Secord's research interests include elucidating the underlying genetic biology of angiogenesis in ovarian cancer, innovative clinical trial design, development of novel targeted therapies for personalized medicine, identification of biomarkers to direct anti-neoplastic therapy, and the incorporation of patient-reported outcomes in clinical trials. She has studied the regulation of angiogenesis in ovarian cancer for approximately 20 years and has recently extended our research to include the immunophenotype of the tumor microenvironment. 

 

Publications

Salinaro, J, Ehrisman, J, Secord, AA, and Davidson, BA. "Incidence of venous thromboembolism among patients receiving neoadjuvant chemotherapy for advanced ovarian cancer.": AMER SOC CLINICAL ONCOLOGY, May 20, 2018.

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Moore, KN, Secord, AA, Geller, MA, Miller, DS, Cloven, NG, and Fleming, GF. = 3 prior chemotherapy regimens.": AMER SOC CLINICAL ONCOLOGY, May 20, 2018.

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Matei, D, Ghamande, S, Roman, L, Alvarez Secord, A, Nemunaitis, J, Markham, MJ, Nephew, KP, Jueliger, S, Oganesian, A, Naim, S, Su, XY, Keer, H, Azab, M, and Fleming, GF. "A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses." Clinical Cancer Research 24, no. 10 (May 15, 2018): 2285-2293.

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Davidson, BA, Ehrisman, J, Abbott, S, Harmon, Z, Secord, AA, Berchuck, A, Lee, PS, Valea, FA, Li, X, Havrilesky, LJ, and Hall, AHS. "Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-grade Endometrial Cancer." International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists 37, no. 3 (May 2018): 252-255.

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Thorsson, V, Gibbs, DL, Brown, SD, Wolf, D, Bortone, DS, Ou Yang, T-H, Porta-Pardo, E, Gao, GF, Plaisier, CL, Eddy, JA, Ziv, E, Culhane, AC, Paull, EO, Sivakumar, IKA, Gentles, AJ, Malhotra, R, Farshidfar, F, Colaprico, A, Parker, JS, Mose, LE, Vo, NS, Liu, J, Liu, Y, Rader, J, Dhankani, V, Reynolds, SM, Bowlby, R, Califano, A, Cherniack, AD, Anastassiou, D, Bedognetti, D, Rao, A, Chen, K, Krasnitz, A, Hu, H, Malta, TM, Noushmehr, H, Pedamallu, CS, Bullman, S, Ojesina, AI, Lamb, A, Zhou, W, Shen, H, Choueiri, TK, Weinstein, JN, Guinney, J, Saltz, J, Holt, RA, Rabkin, CE, Cancer Genome Atlas Research Network, , Lazar, AJ, Serody, JS, Demicco, EG, Disis, ML, Vincent, BG, and Shmulevich, L. "The Immune Landscape of Cancer." Immunity 48, no. 4 (April 5, 2018): 812-830.e14.

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Berger, AC, Korkut, A, Kanchi, RS, Hegde, AM, Lenoir, W, Liu, W, Liu, Y, Fan, H, Shen, H, Ravikumar, V, Rao, A, Schultz, A, Li, X, Sumazin, P, Williams, C, Mestdagh, P, Gunaratne, PH, Yau, C, Bowlby, R, Robertson, AG, Tiezzi, DG, Wang, C, Cherniack, AD, Godwin, AK, Kuderer, NM, Rader, JS, Zuna, RE, Sood, AK, Lazar, AJ, Ojesina, AI, Adebamowo, C, Adebamowo, SN, Baggerly, KA, Chen, T-W, Chiu, H-S, Lefever, S, Liu, L, MacKenzie, K, Orsulic, S, Roszik, J, Shelley, CS, Song, Q, Vellano, CP, Wentzensen, N, Cancer Genome Atlas Research Network, , Weinstein, JN, Mills, GB, Levine, DA, and Akbani, R. "A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers." Cancer Cell 33, no. 4 (April 2, 2018): 690-705.e9.

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Liu, Y, Sethi, NS, Hinoue, T, Schneider, BG, Cherniack, AD, Sanchez-Vega, F, Seoane, JA, Farshidfar, F, Bowlby, R, Islam, M, Kim, J, Chatila, W, Akbani, R, Kanchi, RS, Rabkin, CS, Willis, JE, Wang, KK, McCall, SJ, Mishra, L, Ojesina, AI, Bullman, S, Pedamallu, CS, Lazar, AJ, Sakai, R, Cancer Genome Atlas Research Network, , Thorsson, V, Bass, AJ, and Laird, PW. "Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas." Cancer Cell 33, no. 4 (April 2, 2018): 721-735.e8.

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Taylor, AM, Shih, J, Ha, G, Gao, GF, Zhang, X, Berger, AC, Schumacher, SE, Wang, C, Hu, H, Liu, J, Lazar, AJ, Cancer Genome Atlas Research Network, , Cherniack, AD, Beroukhim, R, and Meyerson, M. "Genomic and Functional Approaches to Understanding Cancer Aneuploidy." Cancer Cell 33, no. 4 (April 2, 2018): 676-689.e3.

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Wang, Z, Yang, B, Zhang, M, Guo, W, Wu, Z, Wang, Y, Jia, L, Li, S, Cancer Genome Atlas Research Network, , Xie, W, and Yang, D. "lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer." Cancer Cell 33, no. 4 (April 2, 2018): 706-720.e9.

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Chen, H, Li, C, Peng, X, Zhou, Z, Weinstein, JN, Liang, H, Caesar-Johnson, SJ, Demchok, JA, Felau, I, Kasapi, M, Ferguson, ML, Hutter, CM, Sofia, HJ, Tarnuzzer, R, Wang, Z, Yang, L, Zenklusen, JC, Zhang, JJ, Chudamani, S, Liu, J, Lolla, L, Naresh, R, Pihl, T, Sun, Q, Wan, Y, Wu, Y, Cho, J, DeFreitas, T, Frazer, S, Gehlenborg, N, Getz, G, Heiman, DI, Kim, J, Lawrence, MS, Lin, P, Meier, S, Noble, MS, Saksena, G, Voet, D, Zhang, H, Bernard, B, Chambwe, N, Dhankani, V, Knijnenburg, T, Kramer, R, Leinonen, K, Liu, Y, Miller, M, Reynolds, S, Shmulevich, I, Thorsson, V, Zhang, W, Akbani, R, Broom, BM, Hegde, AM, Ju, Z, Kanchi, RS, Korkut, A, Li, J, Ling, S, Liu, W, Lu, Y, Mills, GB, Ng, K-S, Rao, A, Ryan, M, Wang, J, Zhang, J, Abeshouse, A, Armenia, J, Chakravarty, D, Chatila, WK, de Bruijn, I, Gao, J, Gross, BE, Heins, ZJ, Kundra, R, La, K, Ladanyi, M, Luna, A, Nissan, MG, Ochoa, A, Phillips, SM, Reznik, E, Sanchez-Vega, F, Sander, C, Schultz, N, Sheridan, R, Sumer, SO, Sun, Y, Taylor, BS, Wang, J, Zhang, H, Anur, P, Peto, M, Spellman, P, Benz, C, Stuart, JM, Wong, CK, Yau, C, Hayes, DN, Parker, JS, Wilkerson, MD, Ally, A, Balasundaram, M, Bowlby, R, Brooks, D, Carlsen, R, Chuah, E, Dhalla, N, Holt, R, Jones, SJM, Kasaian, K, Lee, D, Ma, Y, Marra, MA, Mayo, M, Moore, RA, Mungall, AJ, Mungall, K, Robertson, AG, Sadeghi, S, Schein, JE, Sipahimalani, P, Tam, A, Thiessen, N, Tse, K, Wong, T, Berger, AC, Beroukhim, R, Cherniack, AD, Cibulskis, C, Gabriel, SB, Gao, GF, Ha, G, Meyerson, M, Schumacher, SE, Shih, J, Kucherlapati, MH, Kucherlapati, RS, Baylin, S, Cope, L, Danilova, L, Bootwalla, MS, Lai, PH, Maglinte, DT, Van Den Berg, DJ, Weisenberger, DJ, Auman, JT, Balu, S, Bodenheimer, T, Fan, C, Hoadley, KA, Hoyle, AP, Jefferys, SR, Jones, CD, Meng, S, Mieczkowski, PA, Mose, LE, Perou, AH, Perou, CM, Roach, J, Shi, Y, Simons, JV, Skelly, T, Soloway, MG, Tan, D, Veluvolu, U, Fan, H, Hinoue, T, Laird, PW, Shen, H, Zhou, W, Bellair, M, Chang, K, Covington, K, Creighton, CJ, Dinh, H, Doddapaneni, H, Donehower, LA, Drummond, J, Gibbs, RA, Glenn, R, Hale, W, Han, Y, Hu, J, Korchina, V, Lee, S, Lewis, L, Li, W, Liu, X, Morgan, M, Morton, D, Muzny, D, Santibanez, J, Sheth, M, Shinbrot, E, Wang, L, Wang, M, Wheeler, DA, Xi, L, Zhao, F, Hess, J, Appelbaum, EL, Bailey, M, Cordes, MG, Ding, L, Fronick, CC, Fulton, LA, Fulton, RS, Kandoth, C, Mardis, ER, McLellan, MD, Miller, CA, Schmidt, HK, Wilson, RK, Crain, D, Curley, E, Gardner, J, Lau, K, Mallery, D, Morris, S, Paulauskis, J, Penny, R, Shelton, C, Shelton, T, Sherman, M, Thompson, E, Yena, P, Bowen, J, Gastier-Foster, JM, Gerken, M, Leraas, KM, Lichtenberg, TM, Ramirez, NC, Wise, L, Zmuda, E, Corcoran, N, Costello, T, Hovens, C, Carvalho, AL, de Carvalho, AC, Fregnani, JH, Longatto-Filho, A, Reis, RM, Scapulatempo-Neto, C, Silveira, HCS, Vidal, DO, Burnette, A, Eschbacher, J, Hermes, B, Noss, A, Singh, R, Anderson, ML, Castro, PD, Ittmann, M, Huntsman, D, Kohl, B, Le, X, Thorp, R, Andry, C, Duffy, ER, Lyadov, V, Paklina, O, Setdikova, G, Shabunin, A, Tavobilov, M, McPherson, C, Warnick, R, Berkowitz, R, Cramer, D, Feltmate, C, Horowitz, N, Kibel, A, Muto, M, Raut, CP, Malykh, A, Barnholtz-Sloan, JS, Barrett, W, Devine, K, Fulop, J, Ostrom, QT, Shimmel, K, Wolinsky, Y, Sloan, AE, De Rose, A, Giuliante, F, Goodman, M, Karlan, BY, Hagedorn, CH, Eckman, J, Harr, J, Myers, J, Tucker, K, Zach, LA, Deyarmin, B, Hu, H, Kvecher, L, Larson, C, Mural, RJ, Somiari, S, Vicha, A, Zelinka, T, Bennett, J, Iacocca, M, Rabeno, B, Swanson, P, Latour, M, Lacombe, L, Têtu, B, Bergeron, A, McGraw, M, Staugaitis, SM, Chabot, J, Hibshoosh, H, Sepulveda, A, Su, T, Wang, T, Potapova, O, Voronina, O, Desjardins, L, Mariani, O, Roman-Roman, S, Sastre, X, Stern, M-H, Cheng, F, Signoretti, S, Berchuck, A, Bigner, D, Lipp, E, Marks, J, McCall, S, McLendon, R, Secord, A, Sharp, A, Behera, M, Brat, DJ, Chen, A, Delman, K, Force, S, Khuri, F, Magliocca, K, Maithel, S, Olson, JJ, Owonikoko, T, Pickens, A, Ramalingam, S, Shin, DM, Sica, G, Van Meir, EG, Zhang, H, Eijckenboom, W, Gillis, A, Korpershoek, E, Looijenga, L, Oosterhuis, W, Stoop, H, van Kessel, KE, Zwarthoff, EC, Calatozzolo, C, Cuppini, L, Cuzzubbo, S, DiMeco, F, Finocchiaro, G, Mattei, L, Perin, A, Pollo, B, Chen, C, Houck, J, Lohavanichbutr, P, Hartmann, A, Stoehr, C, Stoehr, R, Taubert, H, Wach, S, Wullich, B, Kycler, W, Murawa, D, Wiznerowicz, M, Chung, K, Edenfield, WJ, Martin, J, Baudin, E, Bubley, G, Bueno, R, De Rienzo, A, Richards, WG, Kalkanis, S, Mikkelsen, T, Noushmehr, H, Scarpace, L, Girard, N, Aymerich, M, Campo, E, Giné, E, Guillermo, AL, Van Bang, N, Hanh, PT, Phu, BD, Tang, Y, Colman, H, Evason, K, Dottino, PR, Martignetti, JA, Gabra, H, Juhl, H, Akeredolu, T, Stepa, S, Hoon, D, Ahn, K, Kang, KJ, Beuschlein, F, Breggia, A, Birrer, M, Bell, D, Borad, M, Bryce, AH, Castle, E, Chandan, V, Cheville, J, Copland, JA, Farnell, M, Flotte, T, Giama, N, Ho, T, Kendrick, M, Kocher, J-P, Kopp, K, Moser, C, Nagorney, D, O’Brien, D, O’Neill, BP, Patel, T, Petersen, G, Que, F, Rivera, M, Roberts, L, Smallridge, R, Smyrk, T, Stanton, M, Thompson, RH, Torbenson, M, Yang, JD, Zhang, L, Brimo, F, Ajani, JA, Gonzalez, AMA, Behrens, C, Bondaruk, J, Broaddus, R, Czerniak, B, Esmaeli, B, Fujimoto, J, Gershenwald, J, Guo, C, Lazar, AJ, Logothetis, C, Meric-Bernstam, F, Moran, C, Ramondetta, L, Rice, D, Sood, A, Tamboli, P, Thompson, T, Troncoso, P, Tsao, A, Wistuba, I, Carter, C, Haydu, L, Hersey, P, Jakrot, V, Kakavand, H, Kefford, R, Lee, K, Long, G, Mann, G, Quinn, M, Saw, R, Scolyer, R, Shannon, K, Spillane, A, Stretch, J, Synott, M, Thompson, J, Wilmott, J, Al-Ahmadie, H, Chan, TA, Ghossein, R, Gopalan, A, Levine, DA, Reuter, V, Singer, S, Singh, B, Tien, NV, Broudy, T, Mirsaidi, C, Nair, P, Drwiega, P, Miller, J, and Smith, J et al.. "A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples." Cell 173, no. 2 (April 2018): 386-399.e12.

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