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Angeles Alvarez Secord, MD

Angeles Secord, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: secor002@mc.duke.edu

My primary research interest has focused on angiogenesis, molecular signatures, clinical trial development, and ovarian cancer. My fundamental goal is to develop a strong translational research program at Duke University in the Gynecologic Oncology Division where knowledge we glean from our basic science research can be incorporated into our clinical trial program. Specifically on anti-angiogenic therapy and molecular tumor signatures to direct therapy in patients with ovarian cancer to determine if a strategy that incorporates both clinical and genomic information can improve clinical outcome, minimize unnecessary toxicity, and impact positively on quality of life.
In addition I am interested in robotic-assisted laparoscopic surgery for women with endometrial, ovarian, and cervical cancers as well as for benign gynecologic conditions.

Education and Training

  • Resident, Obstetrics & Gynecology, Duke University, 1994 - 1998
  • M.D., University of Washington, 1994

Certifications

  • Duke University Medical Center, Masters of Health Sciences in Clinical Research, 2005-2011

Research

Dr. Secord's research interests include elucidating the underlying genetic biology of angiogenesis in ovarian cancer, innovative clinical trial design, development of novel targeted therapies for personalized medicine, identification of biomarkers to direct anti-neoplastic therapy, and the incorporation of patient-reported outcomes in clinical trials. She has studied the regulation of angiogenesis in ovarian cancer for approximately 20 years and has recently extended our research to include the immunophenotype of the tumor microenvironment. 

 

Publications

Krivak, TC, Lele, S, Richard, S, Secord, AA, Leath, CA, Brower, SL, Tian, C, and Moore, RG. "A chemoresponse assay for prediction of platinum resistance in primary ovarian cancer." American Journal of Obstetrics and Gynecology 211, no. 1 (July 2014): 68.e1-68.e8.

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Tew, WP, Sill, M, McMeekin, DS, Secord, AA, Bonebrake, AJ, Schilder, J, Stuckey, A, Rice, L, Tewari, KS, and Aghajanian, C. "A randomized phase II trial of bevacizumab (BV) plus oral everolimus (EV) versus bevacizumab alone for recurrent or persistent epithelial ovarian (EOC), fallopian tube (FTC), or primary peritoneal cancer (PPC)." May 20, 2014.

Scholars@Duke

Roque, DR, Pierce, S, Doll, KM, Davidson, B, Jackson, AL, Ko, EM, Moore, DT, Gehrig, PA, Secord, AA, Havrilesky, LJ, and Bae-Jump, VL. "Endometrial cancer outcomes in hypertensive women treated with beta-blocker." May 20, 2014.

Scholars@Duke

Nakayama, J, Edwards, J, Stine, JE, Pelkofski, E, Gehrlg, PA, Secord, AA, and Duska, LR. "Laparoscopy compared to laparotomy in the management of granulosa cell tumors of the ovary." May 20, 2014.

Scholars@Duke

Havrilesky, LJ, Secord, AA, Ehrisman, JA, Berchuck, A, Valea, FA, Lee, PS, Gaillard, S, Celia, D, Weinfurt, K, Abernethy, AP, and Reed, SD. "Relative influence of factors determining a woman's preference for treatment options in ovarian cancer." May 20, 2014.

Scholars@Duke

Previs, RA, Kilgore, J, Craven, R, Broadwater, G, Bean, S, Wobker, S, DiFurio, M, Bae-Jump, V, Gehrig, PA, and Secord, AA. "Obesity is associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer." International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society 24, no. 4 (May 2014): 670-675.

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Zhang, C, Havrilesky, LJ, Broadwater, G, Di Santo, N, Ehrisman, JA, Lee, PS, Berchuck, A, Alvarez Secord, A, Bean, S, Bentley, RC, and Valea, FA. "Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: A single institution study of 458 patients." Gynecologic Oncology 133, no. 2 (May 2014): 211-215.

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Zhang, C, Havrilesky, LJ, Broadwater, G, Di Santo, N, Ehrisman, JA, Lee, PS, Berchuck, A, Alvarez Secord, A, Bean, S, Bentley, RC, and Valea, FA. "Relationship between minimally invasive hysterectomy, pelvic cytology, and lymph vascular space invasion: a single institution study of 458 patients." Gynecologic oncology 133, no. 2 (May 2014): 211-215.

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Havrilesky, LJ, Secord, AA, Ehrisman, J, Berchuck, A, Valea, FA, Lee, PS, Cella, D, Weinfurt, K, Abernethy, AP, and Reed, SD. "Relative Influence of Factors Determining a Woman’s Preference for Treatment Options in Ovarian Cancer: A Discrete Choice Experiment.": Elsevier BV, May 2014.

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Lee, PS, and Secord, AA. "Targeting molecular pathways in endometrial cancer: A focus on the FGFR pathway." Cancer Treatment Reviews 40, no. 4 (May 1, 2014): 507-512. (Review)

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