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Angeles Alvarez Secord, MD

Angeles Secord, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765
Email: secor002@mc.duke.edu

My primary research interest has focused on angiogenesis, molecular signatures, clinical trial development, and ovarian cancer. My fundamental goal is to develop a strong translational research program at Duke University in the Gynecologic Oncology Division where knowledge we glean from our basic science research can be incorporated into our clinical trial program. Specifically on anti-angiogenic therapy and molecular tumor signatures to direct therapy in patients with ovarian cancer to determine if a strategy that incorporates both clinical and genomic information can improve clinical outcome, minimize unnecessary toxicity, and impact positively on quality of life.
In addition I am interested in robotic-assisted laparoscopic surgery for women with endometrial, ovarian, and cervical cancers as well as for benign gynecologic conditions.

Education and Training

  • Resident, Obstetrics & Gynecology, Duke University, 1994 - 1998
  • M.D., University of Washington, 1994

Certifications

  • Duke University Medical Center, Masters of Health Sciences in Clinical Research, 2005-2011

Research

Dr. Secord's research interests include elucidating the underlying genetic biology of angiogenesis in ovarian cancer, innovative clinical trial design, development of novel targeted therapies for personalized medicine, identification of biomarkers to direct anti-neoplastic therapy, and the incorporation of patient-reported outcomes in clinical trials. She has studied the regulation of angiogenesis in ovarian cancer for approximately 20 years and has recently extended our research to include the immunophenotype of the tumor microenvironment. 

 

Publications

Krivak, T, Secord, AA, Richard, S, III, LC, Moore, R, Coleman, R, Fiorica, J, Barter, J, Downey, G, Tian, C, and Lele, S. "A chemoresponse assay for prediction of platinum resistance in primary ovarian cancer." GYNECOLOGIC ONCOLOGY 131, no. 1 (October 2013): 276-276.

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Karabudak, AA, Hafner, J, Shetty, V, Chen, S, Secord, AA, Morse, MA, and Philip, R. "Autoantibody biomarkers identified by proteomics methods distinguish ovarian cancer from non-ovarian cancer with various CA-125 levels." Journal of Cancer Research and Clinical Oncology 139, no. 10 (October 2013): 1757-1770.

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Lowery, WJ, Lowery, AW, Barnett, JC, Lopez-Acevedo, M, Lee, PS, Secord, AA, and Havrilesky, L. "Cost-effectiveness of early palliative care intervention in recurrent platinum-resistant ovarian cancer." Gynecol Oncol 130, no. 3 (September 2013): 426-430.

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Wenham, RM, Lapolla, J, Lin, H-Y, Apte, SM, Lancaster, JM, Judson, PL, Gonzalez-Bosquet, J, Herschberger, A, Havrilesky, LJ, and Secord, AA. "A phase II trial of docetaxel and bevacizumab in recurrent ovarian cancer within 12 months of prior platinum-based chemotherapy." Gynecologic Oncology 130, no. 1 (July 2013): 19-24.

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Zighelboim, I, Wright, JD, Gao, F, Case, AS, Massad, LS, Mutch, DG, Powell, MA, Thaker, PH, Eisenhauer, EL, Cohn, DE, Valea, FA, Alvarez Secord, A, Lippmann, LT, Dehdashti, F, and Rader, JS. "Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer." Gynecol Oncol 130, no. 1 (July 2013): 64-68.

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Lopez-Acevedo, M, Havrilesky, LJ, Broadwater, G, Kamal, AH, Abernethy, AP, Berchuck, A, Alvarez Secord, A, Tulsky, JA, Valea, F, and Lee, PS. "Timing of end-of-life care discussion with performance on end-of-life quality indicators in ovarian cancer." Gynecologic Oncology 130, no. 1 (July 2013): 156-161.

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Secord, AA, Barnett, JC, Ledermann, JA, Peterson, BL, Myers, ER, and Havrilesky, LJ. "Cost-effectiveness of BRCA1 and BRCA2 mutation testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer." International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society 23, no. 5 (June 2013): 846-852.

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Stine, JE, Pierce, S, Gehrig, PA, Nakayama, J, Havrilesky, LJ, Secord, AA, Chiu, WK, Moore, DT, and Kim, KH. "Recurrence rates in patients with uterine papillary serous cancer with and without breast cancer." May 20, 2013.

Scholars@Duke

Ko, EM, Walter, P, Clark, LH, Jackson, AL, Franasiak, J, Havrilesky, LJ, Secord, AA, Moore, DT, Gehrig, PA, and Bae-Jump, VL. "The impact of diabetes and obesity on endometrial cancer outcomes." May 20, 2013.

Scholars@Duke

Romano-Fitzgerald, S, De Meritens, AB, Secord, AA, and Kohn, EC. "Invasion, metastasis, and angiogenesis." In Principles and Practice of Gynecologic Oncology: Sixth Edition, 72-88. May 8, 2013.

Scholars@Duke

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