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Angeles Alvarez Secord, MD

Angeles Secord, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-3765

My primary research interest has focused on angiogenesis, molecular signatures, clinical trial development, and ovarian cancer. My fundamental goal is to develop a strong translational research program at Duke University in the Gynecologic Oncology Division where knowledge we glean from our basic science research can be incorporated into our clinical trial program. Specifically on anti-angiogenic therapy and molecular tumor signatures to direct therapy in patients with ovarian cancer to determine if a strategy that incorporates both clinical and genomic information can improve clinical outcome, minimize unnecessary toxicity, and impact positively on quality of life.
In addition I am interested in robotic-assisted laparoscopic surgery for women with endometrial, ovarian, and cervical cancers as well as for benign gynecologic conditions.

Education and Training

  • Resident, Obstetrics & Gynecology, Duke University, 1994 - 1998
  • M.D., University of Washington, 1994


  • Duke University Medical Center, Masters of Health Sciences in Clinical Research, 2005-2011


Dr. Secord's research interests include elucidating the underlying genetic biology of angiogenesis in ovarian cancer, innovative clinical trial design, development of novel targeted therapies for personalized medicine, identification of biomarkers to direct anti-neoplastic therapy, and the incorporation of patient-reported outcomes in clinical trials. She has studied the regulation of angiogenesis in ovarian cancer for approximately 20 years and has recently extended our research to include the immunophenotype of the tumor microenvironment. 



Maxwell, GL, Risinger, JI, Hayes, KA, Alvarez, AA, Dodge, RK, Barrett, JC, and Berchuck, A. "Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers." Clinical cancer research : an official journal of the American Association for Cancer Research 6, no. 8 (August 2000): 2999-3005.


Kearney, P, Secord, A, and Zhang, H. "InVEST: interactive and visual edge selection tool for constructing evolutionary trees." Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing (January 2000): 242-253.


Berchuck, A, Alvarez, A, and Futreal, PA. "Prognosis of BRCA1 and 2-associated ovarian cancers." CME Journal of Gynecologic Oncology 4, no. 1 (December 1, 1999): 108-111. (Review)


Alvarez, AA, Krigman, HR, Whitaker, RS, Dodge, RK, and Rodriguez, GC. "The prognostic significance of angiogenesis in epithelial ovarian carcinoma." Clinical cancer research : an official journal of the American Association for Cancer Research 5, no. 3 (March 1999): 587-591.


Maxwell, , Risinger, , Shaw, , Alvarez, , Barrett, , Futreal, , and Berchuck, . "Mutations in the PTEN tumor suppressor gene in cervical carcinomas." International Journal of Gynecological Cancer 8, no. 6 (November 1998): 489-493.

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