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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999


  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine


Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     


Google Scholar



James, AH, Grotegut, C, Ahmadzia, H, Peterson-Layne, C, and Lockhart, E. "Management of Coagulopathy in Postpartum Hemorrhage." Seminars in thrombosis and hemostasis 42, no. 7 (October 3, 2016): 724-731. (Review)

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Highley, LL, Previs, RA, Dotters-Katz, SK, Brancazio, LR, and Grotegut, CA. "Cesarean delivery among women with prolonged labor induction." Journal of perinatal medicine 44, no. 7 (October 2016): 759-766.

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Clowse, MEB, and Grotegut, C. "Racial and Ethnic Disparities in the Pregnancies of Women With Systemic Lupus Erythematosus." Arthritis care & research 68, no. 10 (October 2016): 1567-1572.

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Hill, CC, Lockhart, EL, Thames, E, Paglia, MJ, Small, MJ, James, AH, and Grotegut, CA. "Comparison of the trends in risk factors and management of severe postpartum hemorrhage: Years 2000–2004 versus 2005–2008." Journal of Reproductive Medicine 61, no. 4 (August 1, 2016): 320-326.


Grotegut, CA, Mao, L, Pierce, SL, Swamy, GK, Heine, RP, and Murtha, AP. "Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization." Molecular endocrinology (Baltimore, Md.) 30, no. 4 (April 2016): 455-468.

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Brown, HL, Harris, B, and Grotegut, CA. "Seatbelt use during pregnancy." The American journal of emergency medicine 34, no. 2 (February 2016): 326-328. (Letter)

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Grotegut, CA, Chisholm, CA, Johnson, LNC, Brown, HL, Heine, RP, and James, AH. "Correction: Medical and Obstetric Complications among Pregnant Women Aged 45 and Older." PloS one 11, no. 3 (January 2016): e0151307-.

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Dotters-Katz, SK, Feldman, C, Puechl, A, Grotegut, CA, and Heine, RP. "Risk factors for post-operative wound infection in the setting of chorioamnionitis and cesarean delivery." The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 29, no. 10 (January 2016): 1541-1545.

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Patil, AS, Swamy, GK, Murtha, AP, Heine, RP, Zheng, X, and Grotegut, CA. "Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model." Reproductive sciences (Thousand Oaks, Calif.) 22, no. 12 (December 2015): 1577-1586.

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Wheeler, SM, Dotters-Katz, S, Heine, RP, Grotegut, CA, and Swamy, GK. "Maternal Effects of Respiratory Syncytial Virus Infection during Pregnancy." Emerging infectious diseases 21, no. 11 (November 2015): 1951-1955.

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