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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999


  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine


Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     


Google Scholar



Grotegut, CA, Johnson, LNC, Fitzpatrick, CB, Heine, RP, Swamy, GK, and Murtha, AP. "Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes." Bjog : an International Journal of Obstetrics and Gynaecology 118, no. 6 (May 2011): 735-740.

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Grotegut, CA, Feng, L, Mao, L, Heine, RP, Murtha, AP, and Rockman, HA. "β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration." Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468-E477.

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Grotegut, CA, Paglia, MJ, Johnson, LNC, Thames, B, and James, AH. "Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony." Am J Obstet Gynecol 204, no. 1 (January 2011): 56.e1-56.e6.

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Grotegut, CA, Murtha, A, and Rockman, H. "Beta-arrestin and G Protein-Coupled Receptor Kinase 6 Mediates MAPK Signaling and Cellular Growth in Response to Oxytocin.": MARY ANN LIEBERT INC, October 1, 2010.


Grotegut, CA, Moore, NL, Reddick, KL, Canzoneri, BJ, Boyd, BK, and Brown, HL. "Cervicovaginal fistula presenting during miscarriage." Ultrasound Obstet Gynecol 36, no. 1 (July 2010): 112-114.

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Grotegut, CA, Johnson, LNC, Paglia, MJ, and James, AH. "Oxytocin Exposure in Women with Uterine Atony and Postpartum Hemorrhage." March 2010.


James, AH, Paglia, MJ, Gernsheimer, T, Grotegut, C, and Thames, B. "Blood component therapy in postpartum hemorrhage." Transfusion 49, no. 11 (November 2009): 2430-2433.

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Madan, I, Puri, I, Jain, NJ, Grotegut, C, Nelson, D, and Dandolu, V. "Characteristics of obstetric intensive care unit admissions in New Jersey." The Journal of Maternal Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 22, no. 9 (September 2009): 785-790.

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Shah, AA, Grotegut, CA, Likes, CE, Miller, MJ, and Walmer, DK. "Heterotopic cervical pregnancy treated with transvaginal ultrasound-guided aspiration resulting in cervical site varices within the myometrium." Fertil Steril 91, no. 3 (March 2009): 934.e19-934.e22.

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Geifman-Holtzman, O, Grotegut, CA, Gaughan, JP, Holtzman, EJ, Floro, C, and Hernandez, E. "Noninvasive fetal RhCE genotyping from maternal blood." BJOG 116, no. 2 (January 2009): 144-151. (Review)

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