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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999


  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine


Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     


Google Scholar



Dotters-Katz, SK, James, AH, Gardner, C, Grotegut, C, Colton, K, and Jaffe, TA. "Origin, incidence, and management of nongynecologic pelvic masses seen on cross-sectional imaging." Journal of Reproductive Medicine 60, no. 3 (June 1, 2015): 187-193.


Dotters-Katz, SK, James, AH, Gardner, C, Grotegut, C, Colton, K, and Jaffe, TA. "Origin, Incidence, and Management of Nongynecologic Pelvic Masses Seen on Cross-sectional Imaging." The Journal of Reproductive Medicine 60, no. 5-6 (May 2015): 187-193.


Patel, EM, Goodnight, WH, James, AH, and Grotegut, CA. "Temporal trends in maternal medical conditions and stillbirth." American journal of obstetrics and gynecology 212, no. 5 (May 2015): 673.e1-673.11.

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Allen, TK, Feng, L, Nazzal, M, Grotegut, CA, Buhimschi, IA, and Murtha, AP. "The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro." Anesthesia and Analgesia 120, no. 5 (May 2015): 1085-1094.

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Rada, CC, Pierce, SL, Grotegut, CA, and England, SK. "Intrauterine telemetry to measure mouse contractile pressure in vivo." Journal of visualized experiments : JoVE, no. 98 (April 6, 2015): e52541-.

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Pierce, S, Gilner, J, Brown, H, Murtha, AP, and Grotegut, CA. "Cigarette Smoke Increases Placental Adrenomedullin and Uterine Natural Killer Cell Recruitment - A Possible Role in Cigarette Smoke-Mediate Protection From Preeclampsia." REPRODUCTIVE SCIENCES 22 (March 2015): 289A-289A.


Dotters-Katz, SK, Patel, E, Grotegut, CA, and Heine, RP. "Acute infectious morbidity in multiple gestation." Infectious Diseases in Obstetrics and Gynecology 2015 (January 5, 2015): 173261-null.

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Abdul-Kadir, R, McLintock, C, Ducloy, AS, El-Refaey, H, England, A, Federici, AB, Grotegut, CA, Halimeh, S, Herman, JH, Hofer, S, James, AH, Kouides, PA, Paidas, MJ, Peyvandi, F, and Winikoff, R. "Erratum: Evaluation and management of postpartum hemorrhage: Consensus from an international expert panel (Transfusion (2014) 54 (1756-1768))." Transfusion 55, no. 3 (January 1, 2015): 691-. (Review)

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Berggren, EK, Roeder, HA, Boggess, KA, Moss, K, Offenbacher, S, Campbell, E, and Grotegut, CA. "First-trimester maternal serum C-reactive protein as a predictor of third-trimester impaired glucose tolerance." Reproductive sciences (Thousand Oaks, Calif.) 22, no. 1 (January 2015): 90-93.

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Patel, EM, Swamy, GK, Heine, RP, Kuller, JA, James, AH, and Grotegut, CA. "Medical and obstetric complications among pregnant women with cystic fibrosis." American Journal of Obstetrics and Gynecology 212, no. 1 (January 1, 2015): 98e1-98e9.

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