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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999


  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine


Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     


Google Scholar



Lewis, LS, Pan, HY, Heine, RP, Brown, HL, Brancazio, LR, and Grotegut, CA. "Labor and pregnancy outcomes after adoption of a more conservative oxytocin labor protocol." Obstetrics and gynecology 123 Suppl 1 (May 2014): 66S-.

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Feng, L, Antczak, BC, Lan, L, Grotegut, CA, Thompson, JL, Allen, TK, and Murtha, AP. "Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)." Placenta 35, no. 5 (May 2014): 331-333.

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Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progesterone receptor membrane component 1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix metalloproteinase 9 activity in vitro." Reprod Sci 21, no. 2 (February 2014): 260-268.

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Murtha, AP, Fortner, KB, Grotegut, CA, Ransom, CE, Bentley, RC, Feng, L, Lan, L, Heine, RP, and Seed, PC. "Bacteria Localization and Chorion Thinning among Preterm Premature Rupture of Membranes." Plos One (January 8, 2014). (Academic Article)

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Gregory, SG, Anthopolos, R, Osgood, CE, Grotegut, CA, and Miranda, ML. "Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990–1998) and Education Research (1997–2007) Databases." Obstetrical & Gynecological Survey 69, no. 1 (January 2014): 7-9.

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Kraus, DM, Feng, L, Heine, RP, Brown, HL, Caron, KM, Murtha, AP, and Grotegut, CA. "Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion." Reprod Sci 21, no. 1 (January 2014): 63-71.

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Abdul-Kadir, R, McLintock, C, Ducloy, AS, El-Refaey, H, England, A, Federici, AB, Grotegut, CA, Halimeh, S, Herman, JH, Hofer, S, James, AH, Kouides, PA, Paidas, MJ, Peyvandi, F, and Winikoff, R. "Evaluation and management of postpartum hemorrhage: Consensus from an international expert panel." Transfusion 54, no. 7 (January 1, 2014): 1756-1768.

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Grotegut, CA, Kuklina, EV, Anstrom, KJ, Heine, RP, Callaghan, WM, Myers, ER, and James, AH. "Factors associated with the change in prevalence of cardiomyopathy at delivery in the period 2000-2009: A population-based prevalence study." BJOG: An International Journal of Obstetrics and Gynaecology 121, no. 11 (2014): 1386-1394.

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Cotten, CM, Murtha, AP, Goldberg, RN, Grotegut, CA, Smith, PB, Goldstein, RF, Fisher, KA, Gustafson, KE, Waters-Pick, B, Swamy, GK, Rattray, B, Tan, S, and Kurtzberg, J. "Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy." Journal of Pediatrics 164, no. 5 (January 1, 2014).

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Grotegut, CA, Chisholm, CA, Johnson, LNC, Brown, HL, Heine, RP, and James, AH. "Medical and obstetric complications among pregnant women aged 45 and older." PloS one 9, no. 4 (January 2014): e96237-.

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