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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999


  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine


Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     


Google Scholar



Cotten, CM, Murtha, AP, Goldberg, RN, Grotegut, CA, Smith, PB, Goldstein, RF, Fisher, KA, Gustafson, KE, Waters-Pick, B, Swamy, GK, Rattray, B, Tan, S, and Kurtzberg, J. "Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy." Journal of Pediatrics 164, no. 5 (January 1, 2014).

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Grotegut, CA, Chisholm, CA, Johnson, LNC, Brown, HL, Heine, RP, and James, AH. "Medical and obstetric complications among pregnant women aged 45 and older." PloS one 9, no. 4 (January 2014): e96237-.

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Matson, BC, Corty, RW, Karpinich, NO, Murtha, AP, Valdar, W, Grotegut, CA, and Caron, KM. "Midregional pro-adrenomedullin plasma concentrations are blunted in severe preeclampsia." Placenta 35, no. 9 (January 1, 2014): 780-783.

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Ahmadzia, HK, Thomas, SM, Dude, AM, Grotegut, CA, and Boyd, BK. "Prediction of birthweight from third-trimester ultrasound in morbidly obese women." January 1, 2014.

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Feng, L, Antczak, BC, Lan, L, Grotegut, CA, Thompson, JL, Allen, TK, and Murtha, AP. "Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)." Placenta 35, no. 5 (January 1, 2014): 331-333.

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Reddick, KLB, Smrtka, MP, Grotegut, CA, James, AH, Brancazio, LR, and Swamy, GK. "The effects of intermittent pneumatic compression during cesarean delivery on fibrinolysis." American Journal of Perinatology 31, no. 9 (January 1, 2014): 735-740.

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Gunatilake, RP, Smrtka, MP, Harris, B, Kraus, DM, Small, MJ, Grotegut, CA, and Brown, HL. "Predictors of failed trial of labor among women with an extremely obese body mass index." American Journal of Obstetrics and Gynecology 209, no. 6 (December 1, 2013).

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Gunatilake, RP, Smrtka, MP, Harris, B, Kraus, DM, Small, MJ, Grotegut, CA, and Brown, HL. "Predictors of failed trial of labor among women with an extremely obese body mass index." Am J Obstet Gynecol 209, no. 6 (December 2013): 562.e1-562.e5.

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Grotegut, CA, Gunatilake, RP, Feng, L, Heine, RP, and Murtha, AP. "The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy." Reproductive Sciences (Thousand Oaks, Calif.) 20, no. 12 (December 2013): 1471-1477.

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Gregory, SG, Anthopolos, R, Osgood, CE, Grotegut, CA, and Miranda, ML. "Association of autism with induced or augmented childbirth in North Carolina Birth Record (1990-1998) and Education Research (1997-2007) databases." JAMA Pediatr 167, no. 10 (October 2013): 959-966.

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