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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999


  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine


Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     


Google Scholar



Fortner, KB, Fitzpatrick, CB, Grotegut, CA, Swamy, GK, Murtha, AP, Heine, RP, and Brown, HL. "Cervical dilation as a predictor of pregnancy outcome following emergency cerclage." J Matern Fetal Neonatal Med 25, no. 10 (October 2012): 1884-1888.

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Canzoneri, BJ, Grotegut, CA, Swamy, GK, Brancazio, LR, Sinclair, T, Heine, PR, and Murtha, AP. "Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics." J Matern Fetal Neonatal Med 25, no. 8 (August 2012): 1329-1332.

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Fitzpatrick, CB, Grotegut, CA, Bishop, TS, Canzoneri, BJ, Heine, RP, and Swamy, GK. "Cervical ripening with foley balloon plus fixed versus incremental low-dose oxytocin: a randomized controlled trial." J Matern Fetal Neonatal Med 25, no. 7 (July 2012): 1006-1010.

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Beiswenger, TR, Feng, L, Brown, HL, Heine, RP, Murtha, AP, and Grotegut, CA. "The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin." Reprod Sci 19, no. 5 (May 2012): 526-533.

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Feng, L, Antczak, B, Thompson, J, Grotegut, CA, and Murtha, AP. "PGRMC1 Expression in Fetal Membrane Layers among Women with Preterm Premature Rupture of the Membranes (PPROM)." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 295A-295A.


Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progestins Diminish Cytokine Induced MMP9 Activity in a Human Cytotrophoblast Cell Line Not Expressing the Nuclear Progesterone Receptor." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 294A-294A.


Paglia, MJ, Grotegut, CA, Johnson, LNC, Thames, B, and James, AH. "Body mass index and severe postpartum hemorrhage." Gynecol Obstet Invest 73, no. 1 (2012): 70-74.

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Grotegut, CA, Dulitzki, M, Gaughan, JP, Achiron, R, Schiff, E, and Geifman-Holtzman, O. "Transvaginal ultrasound of cervical length and its correlation to digital cervical examination, time to spontaneous labor and mode of delivery." Arch Gynecol Obstet 284, no. 4 (October 2011): 855-859.

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Grotegut, CA, Johnson, LNC, Fitzpatrick, CB, Heine, RP, Swamy, GK, and Murtha, AP. "Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes." BJOG 118, no. 6 (May 2011): 735-740.

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Grotegut, CA, Feng, L, Mao, L, Heine, RP, Murtha, AP, and Rockman, HA. "β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration." Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468-E477.

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