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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220
Email: chad.grotegut@duke.edu

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999

Certifications

  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine

Research

Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     

PubMed

Google Scholar

 

Publications

Dotters-Katz, SK, Grotegut, CA, and Heine, RP. "The effects of anemia on pregnancy outcome in patients with pyelonephritis." Infectious Diseases in Obstetrics and Gynecology 2013 (January 2013): 780960-null.

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Fletcher, S, Grotegut, CA, and James, AH. "Lochia patterns among normal women: a systematic review." Journal of Women'S Health (2002) 21, no. 12 (December 2012): 1290-1294. (Review)

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Fortner, KB, Fitzpatrick, CB, Grotegut, CA, Swamy, GK, Murtha, AP, Heine, RP, and Brown, HL. "Cervical dilation as a predictor of pregnancy outcome following emergency cerclage." The Journal of Maternal Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 25, no. 10 (October 2012): 1884-1888.

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Canzoneri, BJ, Grotegut, CA, Swamy, GK, Brancazio, LR, Sinclair, T, Heine, PR, and Murtha, AP. "Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics." The Journal of Maternal Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 25, no. 8 (August 2012): 1329-1332.

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Fitzpatrick, CB, Grotegut, CA, Bishop, TS, Canzoneri, BJ, Heine, RP, and Swamy, GK. "Cervical ripening with foley balloon plus fixed versus incremental low-dose oxytocin: a randomized controlled trial." The Journal of Maternal Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 25, no. 7 (July 2012): 1006-1010.

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Beiswenger, TR, Feng, L, Brown, HL, Heine, RP, Murtha, AP, and Grotegut, CA. "The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin." Reprod Sci 19, no. 5 (May 2012): 526-533.

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Feng, L, Antczak, B, Thompson, J, Grotegut, CA, and Murtha, AP. "PGRMC1 Expression in Fetal Membrane Layers among Women with Preterm Premature Rupture of the Membranes (PPROM)." REPRODUCTIVE SCIENCES 19, no. S3 (March 1, 2012): 295A-295A.

Scholars@Duke

Feng, L, Antczak, B, Thompson, J, Grotegut, CA, and Murtha, AP. "PGRMC1 Expression in Fetal Membrane Layers among Women with Preterm Premature Rupture of the Membranes (PPROM)." REPRODUCTIVE SCIENCES 19, no. S3 (March 1, 2012): 295A-295A.

Scholars@Duke

Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progestins Diminish Cytokine Induced MMP9 Activity in a Human Cytotrophoblast Cell Line Not Expressing the Nuclear Progesterone Receptor." REPRODUCTIVE SCIENCES 19, no. S3 (March 1, 2012): 294A-294A.

Scholars@Duke

Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progestins Diminish Cytokine Induced MMP9 Activity in a Human Cytotrophoblast Cell Line Not Expressing the Nuclear Progesterone Receptor." REPRODUCTIVE SCIENCES 19, no. S3 (March 1, 2012): 294A-294A.

Scholars@Duke

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