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Friederike Luking Jayes, DVM, PhD

Property title
Assistant Professor of Obstetrics and Gynecology
Campus Mail: 238 Sands Building, Box 103209, Durham, NC 27710-3209
Phone: (919) 668-3973
Email: friederike.jayes@duke.edu

I received my Veterinary Medicine degree in Giessen, Germany and my PhD in Physiology from North Carolina State University in Raleigh. My research interests have always centered on the physiology and endocrinology of the female reproductive system. Uterine fibroids have a major impact on women’s health, on quality of life and on health cost. The etiology of this disease remains unknown and non-surgical therapies are either short-lived or have significant side effects. Good translational research is needed, combining the skills, backgrounds and visions of basic and clinical researchers. The Reproductive Biology and Perinatal Lab (RBPL) has a great mix of projects and includes clinical and basic researchers. The fibroid research within the lab embraces an entirely new direction in thinking about uterine fibroids. We are looking at fibroids as more than neoplasms, and consider them to be a fibrotic disease. I also love teaching and believe that it happens not only in the classroom but also in the laboratory. Our group works hard to invite and accommodate students, residents, and fellows. We teach not only methods and procedures, but also approaches, limitations and design of experiments in hypothesis driven research. This knowledge and experience will serve any future researcher and clinician well when reading the literature, asking their own questions, and during collaborations. As a team, we are on our way to make a difference in woman’s health.

Education and Training

  • Ph.D., North Carolina State University, 1995
  • D.V.M., Justus Liebig University Giessen (Germany), 1987

Publications

Feng, L, Jayes, FL, Johnson, LNC, Schomberg, DW, and Leppert, PC. "Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin." Current protein & peptide science 18, no. 2 (January 2017): 155-166.

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Jayes, FL, Liu, B, Moutos, FT, Kuchibhatla, M, Guilak, F, and Leppert, PC. "Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum." American journal of obstetrics and gynecology 215, no. 5 (November 2016): 596.e1-596.e8.

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Potts, LC, Feng, L, Seed, PC, Jayes, FL, Kuchibhatla, M, Antczak, B, Nazzal, MK, and Murtha, AP. "Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System." Biology of reproduction 94, no. 5 (May 2016): 119-.

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Potts, LC, Feng, L, Jayes, FL, and Murtha, AP. "341: Novel ex vivo system to evaluate inflammation of gestational membranes in response to U. parvum." January 2016.

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Jayes, FL, Liu, B, Moutos, FT, Guilak, F, and Leppert, PC. "Stiffness of Uterine Fibroids Is Reduced After Treatment With Purified Clostridial Collagenase Due To Collagen Degradation." REPRODUCTIVE SCIENCES 22 (March 2015): 303A-303A.

Scholars@Duke

Brunengraber, LN, Jayes, FL, and Leppert, PC. "Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids." Reproductive sciences (Thousand Oaks, Calif.) 21, no. 12 (December 2014): 1452-1459.

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Jayes, FL, Burns, KA, Rodriguez, KF, Kissling, GE, and Korach, KS. "The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary. (Published online)" Biol Reprod 90, no. 2 (February 2014): 24-.

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Leppert, PC, Jayes, FL, and Segars, JH. "The extracellular matrix contributes to mechanotransduction in uterine fibroids." Obstetrics and gynecology international 2014 (January 2014): 783289-. (Review)

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Jayes, F, Ma, X, and Leppert, P. "Treatment of uterine fibroids with highly purified clostridial collagenase." Fertility and Sterility 98, no. 3 (September 2012): S232-S232.

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Roeder, H, Jayes, F, Feng, L, and Leppert, PC. "CDB-4124 does not cause apoptosis in cultured fibroid cells." Reprod Sci 18, no. 9 (September 2011): 850-857.

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