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Friederike Luking Jayes, DVM, PhD

Property title
Assistant Professor in Obstetrics and Gynecology
Campus Mail: 244 Baker House, Box 3084, Durham, NC 27710
Phone: (919) 668-3973
Email: friederike.jayes@duke.edu

I received my Veterinary Medicine degree in Giessen, Germany and my PhD in Physiology from North Carolina State University in Raleigh. My research interests have always centered on the physiology and endocrinology of the female reproductive system. Uterine fibroids have a major impact on women’s health, on quality of life and on health cost. The etiology of this disease remains unknown and non-surgical therapies are either short-lived or have significant side effects. Good translational research is needed, combining the skills, backgrounds and visions of basic and clinical researchers. The Reproductive Biology and Perinatal Lab (RBPL) has a great mix of projects and includes clinical and basic researchers. The fibroid research within the lab embraces an entirely new direction in thinking about uterine fibroids. We are looking at fibroids as more than neoplasms, and consider them to be a fibrotic disease. I also love teaching and believe that it happens not only in the classroom but also in the laboratory. Our group works hard to invite and accommodate students, residents, and fellows. We teach not only methods and procedures, but also approaches, limitations and design of experiments in hypothesis driven research. This knowledge and experience will serve any future researcher and clinician well when reading the literature, asking their own questions, and during collaborations. As a team, we are on our way to make a difference in woman’s health.

Education and Training

  • Ph.D., North Carolina State University, 1995
  • D.V.M., Justus Liebig University Giessen (Germany), 1987

Publications

Jayes, Friederike L., Betty Liu, Liping Feng, Nydea Aviles-Espinoza, Sergey Leikin, and Phyllis C. Leppert. “Evidence of biomechanical and collagen heterogeneity in uterine fibroids.” Plos One 14, no. 4 (2019): e0215646. https://doi.org/10.1371/journal.pone.0215646.

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Feng, Liping, Friederike L. Jayes, Lauren N. C. Johnson, David W. Schomberg, and Phyllis C. Leppert. “Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.” Curr Protein Pept Sci 18, no. 2 (2017): 155–66. https://doi.org/10.2174/1389203717666160322145731.

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Jayes, Friederike L., Betty Liu, Franklin T. Moutos, Maragatha Kuchibhatla, Farshid Guilak, and Phyllis C. Leppert. “Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.” Am J Obstet Gynecol 215, no. 5 (November 2016): 596.e1-596.e8. https://doi.org/10.1016/j.ajog.2016.05.006.

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Potts, Lauren C., Liping Feng, Patrick C. Seed, Friederike L. Jayes, Maragatha Kuchibhatla, Brian Antczak, Matthew K. Nazzal, and Amy P. Murtha. “Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System.” Biol Reprod 94, no. 5 (May 2016): 119. https://doi.org/10.1095/biolreprod.115.137596.

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Potts, Lauren C., Liping Feng, Friederike L. Jayes, and Amy P. Murtha. “341: Novel ex vivo system to evaluate inflammation of gestational membranes in response to U. parvum.” In American Journal of Obstetrics and Gynecology, 214:S192–93. Elsevier BV, 2016. https://doi.org/10.1016/j.ajog.2015.10.381.

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Sayres, L., L. Feng, F. Jayes, and A. Murtha. “19: Development of a dual-chamber gestational membrane explant system to investigate inflammatory response to bacterial presence.” In American Journal of Obstetrics and Gynecology, 213:891–92. Elsevier BV, 2015. https://doi.org/10.1016/j.ajog.2015.09.026.

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Jayes, Friederike L., Betty Liu, Franklin T. Moutos, Farshid Guilak, and Phyllis C. Leppert. “Stiffness of Uterine Fibroids Is Reduced After Treatment With Purified Clostridial Collagenase Due To Collagen Degradation.” Reproductive Sciences 22 (March 1, 2015): 303A-303A.

Scholars@Duke

Brunengraber, Lisa N., Friederike L. Jayes, and Phyllis C. Leppert. “Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids.” Reprod Sci 21, no. 12 (December 2014): 1452–59. https://doi.org/10.1177/1933719114553449.

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Jayes, Friederike L., Katherine A. Burns, Karina F. Rodriguez, Grace E. Kissling, and Kenneth S. Korach. “The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the ovary.” Biol Reprod 90, no. 2 (February 2014): 24. https://doi.org/10.1095/biolreprod.113.113316.

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Leppert, Phyllis C., Friederike L. Jayes, and James H. Segars. “The extracellular matrix contributes to mechanotransduction in uterine fibroids.” Obstet Gynecol Int 2014 (2014): 783289. https://doi.org/10.1155/2014/783289.

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