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Friederike Luking Jayes, DVM, PhD

Property title
Assistant Professor of Obstetrics and Gynecology
Campus Mail: 238 Sands Building, Box 103209, Durham, NC 27710-3209
Phone: (919) 668-3973
Email: friederike.jayes@duke.edu

I received my Veterinary Medicine degree in Giessen, Germany and my PhD in Physiology from North Carolina State University in Raleigh. My research interests have always centered on the physiology and endocrinology of the female reproductive system. Uterine fibroids have a major impact on women’s health, on quality of life and on health cost. The etiology of this disease remains unknown and non-surgical therapies are either short-lived or have significant side effects. Good translational research is needed, combining the skills, backgrounds and visions of basic and clinical researchers. The Reproductive Biology and Perinatal Lab (RBPL) has a great mix of projects and includes clinical and basic researchers. The fibroid research within the lab embraces an entirely new direction in thinking about uterine fibroids. We are looking at fibroids as more than neoplasms, and consider them to be a fibrotic disease. I also love teaching and believe that it happens not only in the classroom but also in the laboratory. Our group works hard to invite and accommodate students, residents, and fellows. We teach not only methods and procedures, but also approaches, limitations and design of experiments in hypothesis driven research. This knowledge and experience will serve any future researcher and clinician well when reading the literature, asking their own questions, and during collaborations. As a team, we are on our way to make a difference in woman’s health.

Education and Training

  • Ph.D., North Carolina State University, 1995
  • D.V.M., Justus Liebig University Giessen (Germany), 1987

Publications

Taylor, DK, Jayes, FL, House, AJ, and Ochieng, MA. "Temperature-responsive biocompatible copolymers incorporating hyperbranched polyglycerols for adjustable functionality." J Funct Biomater 2, no. 3 (August 23, 2011): 173-194.

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Hewitt, SC, Kissling, GE, Fieselman, KE, Jayes, FL, Gerrish, KE, and Korach, KS. "Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene." FASEB J 24, no. 12 (December 2010): 4660-4667.

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Feng, L, Jayes, FL, Jung, S-H, and Leppert, PC. "VITAMIN D RECEPTOR (VDR) IS OVER-EXPRESSED IN THE CENTER OF UTERINE FIBROIDS." September 2010.

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Rodriguez, KF, Couse, JF, Jayes, FL, Hamilton, KJ, Burns, KA, Taniguchi, F, and Korach, KS. "Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}." Endocrinology 151, no. 6 (June 2010): 2826-2834.

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Roeder, HA, Jayes, FL, Feng, L, and Leppert, PC. "Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells." 57th Annual Meeting of the Society-for-Gynecologic-Investigation. Orlando, FL. March 24, 2010 - March 27, 2010. SAGE PUBLICATIONS INC, March 1, 2010.

Scholars@Duke

Roeder, HA, Jayes, FL, Feng, L, and Leppert, PC. "Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells." 57th Annual Meeting of the Society-for-Gynecologic-Investigation. Orlando, FL. March 24, 2010 - March 27, 2010. SAGE PUBLICATIONS INC, March 1, 2010.

Scholars@Duke

Johnson, LNC, Jayes, FL, Feng, L, and Leppert, PC. "Factors Involved in Early Uterine Fibroid Development: The Initiation of Early Wound Healing Responses in Myometrial Cells." 43rd Annual Meeting of the Society-for-the-Study-of-Reproduction. Milwaukee, WI. July 31, 2010 - August 3, 2010. SOC STUDY REPRODUCTION, January 1, 2010.

Scholars@Duke

Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

Gavrilova-Jordan, LP, Zhang, L, Schomberg, D, Jayes, FL, Feng, L, and Price, TM. "Expression of a Truncated Progesterone Receptor (PR-M) Correlates with Mitochondrial Content in Human Tissues." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

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