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Friederike Luking Jayes, DVM, PhD

Property title
Assistant Professor of Obstetrics and Gynecology
Campus Mail: 238 Sands Building, Box 103209, Durham, NC 27710-3209
Phone: (919) 668-3973
Email: friederike.jayes@duke.edu

I received my Veterinary Medicine degree in Giessen, Germany and my PhD in Physiology from North Carolina State University in Raleigh. My research interests have always centered on the physiology and endocrinology of the female reproductive system. Uterine fibroids have a major impact on women’s health, on quality of life and on health cost. The etiology of this disease remains unknown and non-surgical therapies are either short-lived or have significant side effects. Good translational research is needed, combining the skills, backgrounds and visions of basic and clinical researchers. The Reproductive Biology and Perinatal Lab (RBPL) has a great mix of projects and includes clinical and basic researchers. The fibroid research within the lab embraces an entirely new direction in thinking about uterine fibroids. We are looking at fibroids as more than neoplasms, and consider them to be a fibrotic disease. I also love teaching and believe that it happens not only in the classroom but also in the laboratory. Our group works hard to invite and accommodate students, residents, and fellows. We teach not only methods and procedures, but also approaches, limitations and design of experiments in hypothesis driven research. This knowledge and experience will serve any future researcher and clinician well when reading the literature, asking their own questions, and during collaborations. As a team, we are on our way to make a difference in woman’s health.

Education and Training

  • Ph.D., North Carolina State University, 1995
  • D.V.M., Justus Liebig University Giessen (Germany), 1987

Publications

Jayes, FL, Proia, AD, Dash, RC, Feng, L, and Leppert, PC. "The Duke Uterine Fibroid Tissue Repository - A Stepping Stone for Translational Research." REPRODUCTIVE SCIENCES 16, no. 3 (March 2009): 210A-211A.

Scholars@Duke

Wang, J, Scully, K, Zhu, X, Cai, L, Zhang, J, Prefontaine, GG, Krones, A, Ohgi, KA, Zhu, P, Garcia-Bassets, I, Liu, F, Taylor, H, Lozach, J, Jayes, FL, Korach, KS, Glass, CK, Fu, X-D, and Rosenfeld, MG. "Opposing LSD1 complexes function in developmental gene activation and repression programmes." Nature 446, no. 7138 (April 19, 2007): 882-887.

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Lindzey, J, Jayes, FL, Yates, MM, Couse, JF, and Korach, KS. "The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-alpha." J Endocrinol 191, no. 1 (October 2006): 309-317.

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Jayes, FL, Couse, JF, and Korach, KS. "Subfertility in female estrogen receptor-b null mice is partially due to a submaximal luteinizing hormone (LH) surge." 2006.

Scholars@Duke

Jayes, FL, and Davis, BJ. "Granulosa cell function is impaired by environmentally relevant levels of mono-(2-ethylhexyl) phthalate (MEHP)." 2004.

Scholars@Duke

Wolkowicz, MJ, Shetty, J, Westbrook, A, Klotz, K, Jayes, F, Mandal, A, Flickinger, CJ, and Herr, JC. "Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis." Biology of reproduction 69, no. 3 (September 2003): 735-745.

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Shetty, J, Wolkowicz, MJ, Digilio, LC, Klotz, KL, Jayes, FL, Diekman, AB, Westbrook, VA, Farris, EM, Hao, Z, Coonrod, SA, Flickinger, CJ, and Herr, JC. "SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction." J Biol Chem 278, no. 33 (August 15, 2003): 30506-30515.

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Mandal, A, Klotz, KL, Shetty, J, Jayes, FL, Wolkowicz, MJ, Bolling, LC, Coonrod, SA, Black, MB, Diekman, AB, Haystead, TAJ, Flickinger, CJ, and Herr, JC. "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa." Biol Reprod 68, no. 5 (May 2003): 1525-1537.

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Wright, PW, Bolling, LC, Calvert, ME, Sarmento, OF, Berkeley, EV, Shea, MC, Hao, Z, Jayes, FC, Bush, LA, Shetty, J, Shore, AN, Reddi, PP, Tung, KS, Samy, E, Allietta, MM, Sherman, NE, Herr, JC, and Coonrod, SA. "ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets." Developmental biology 256, no. 1 (April 2003): 73-88.

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Ficarro, S, Chertihin, O, Westbrook, VA, White, F, Jayes, F, Kalab, P, Marto, JA, Shabanowitz, J, Herr, JC, Hunt, DF, and Visconti, PE. "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation." The Journal of biological chemistry 278, no. 13 (March 2003): 11579-11589.

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