Wolkowicz, MJ, Shetty, J, Westbrook, A, Klotz, K, Jayes, F, Mandal, A, Flickinger, CJ, and Herr, JC. "Equatorial segment protein defines a discrete acrosomal subcompartment persisting throughout acrosomal biogenesis." Biology of reproduction 69, no. 3 (September 2003): 735-745.
Friederike Luking Jayes, DVM, PhD
I received my Veterinary Medicine degree in Giessen, Germany and my PhD in Physiology from North Carolina State University in Raleigh. My research interests have always centered on the physiology and endocrinology of the female reproductive system. Uterine fibroids have a major impact on women’s health, on quality of life and on health cost. The etiology of this disease remains unknown and non-surgical therapies are either short-lived or have significant side effects. Good translational research is needed, combining the skills, backgrounds and visions of basic and clinical researchers. The Reproductive Biology and Perinatal Lab (RBPL) has a great mix of projects and includes clinical and basic researchers. The fibroid research within the lab embraces an entirely new direction in thinking about uterine fibroids. We are looking at fibroids as more than neoplasms, and consider them to be a fibrotic disease. I also love teaching and believe that it happens not only in the classroom but also in the laboratory. Our group works hard to invite and accommodate students, residents, and fellows. We teach not only methods and procedures, but also approaches, limitations and design of experiments in hypothesis driven research. This knowledge and experience will serve any future researcher and clinician well when reading the literature, asking their own questions, and during collaborations. As a team, we are on our way to make a difference in woman’s health.
Education and Training
- Ph.D., North Carolina State University, 1995
- D.V.M., Justus Liebig University Giessen (Germany), 1987
Selected Grants and Awards
Shetty, J, Wolkowicz, MJ, Digilio, LC, Klotz, KL, Jayes, FL, Diekman, AB, Westbrook, VA, Farris, EM, Hao, Z, Coonrod, SA, Flickinger, CJ, and Herr, JC. "SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction." J Biol Chem 278, no. 33 (August 15, 2003): 30506-30515.
Mandal, A, Klotz, KL, Shetty, J, Jayes, FL, Wolkowicz, MJ, Bolling, LC, Coonrod, SA, Black, MB, Diekman, AB, Haystead, TAJ, Flickinger, CJ, and Herr, JC. "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa." Biol Reprod 68, no. 5 (May 2003): 1525-1537.
Wright, PW, Bolling, LC, Calvert, ME, Sarmento, OF, Berkeley, EV, Shea, MC, Hao, Z, Jayes, FC, Bush, LA, Shetty, J, Shore, AN, Reddi, PP, Tung, KS, Samy, E, Allietta, MM, Sherman, NE, Herr, JC, and Coonrod, SA. "ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets." Developmental biology 256, no. 1 (April 2003): 73-88.
Ficarro, S, Chertihin, O, Westbrook, VA, White, F, Jayes, F, Kalab, P, Marto, JA, Shabanowitz, J, Herr, JC, Hunt, DF, and Visconti, PE. "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation." The Journal of biological chemistry 278, no. 13 (March 2003): 11579-11589.
Mandal, A, Klotz, KL, Shetty, J, Jayes, FL, Wolkowicz, MJ, Bolling, LC, Coonrod, SA, Black, MB, Diekman, AB, Haystead, TAJ, Flickinger, CJ, and Herr, JC. "SLLP1, a novel non-bacteriolytic c lysozyme-like protein in the acrosome of human spermatozoa." BIOLOGY OF REPRODUCTION 66 (2002): 113-114.
Shetty, J, Diekman, AB, Jayes, FC, Sherman, NE, Naaby-Hansen, S, Flickinger, CJ, and Herr, JC. "Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates." Electrophoresis 22, no. 14 (August 2001): 3053-3066.
Flickinger, CJ, Rao, J, Bush, LA, Sherman, NE, Oko, RJ, Jayes, FC, and Herr, JC. "Outer dense fiber proteins are dominant postobstruction autoantigens in adult Lewis rats." Biology of reproduction 64, no. 5 (May 2001): 1451-1459.
Turner, RM, Musse, MP, Mandal, A, Klotz, K, Jayes, FC, Herr, JC, Gerton, GL, Moss, SB, and Chemes, HE. "Molecular genetic analysis of two human sperm fibrous sheath proteins, AKAP4 and AKAP3, in men with dysplasia of the fibrous sheath." Journal of andrology 22, no. 2 (March 2001): 302-315.
Mandal, A, Klotz, K, Wolkowicz, MJ, Shetty, J, Jayes, FL, Flickinger, CJ, and Herr, JC. "APL17 and APLX: Two novel human acrosomal pseudo-lysozymes." December 2000.