Jayes, FC, Day, RN, Garmey, JC, Urban, RJ, Zhang, G, and Veldhuis, JD. "Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3',5'-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells." Endocrinology 141, no. 7 (July 2000): 2377-2384.
Friederike Luking Jayes, DVM, PhD
I received my Veterinary Medicine degree in Giessen, Germany and my PhD in Physiology from North Carolina State University in Raleigh. My research interests have always centered on the physiology and endocrinology of the female reproductive system. Uterine fibroids have a major impact on women’s health, on quality of life and on health cost. The etiology of this disease remains unknown and non-surgical therapies are either short-lived or have significant side effects. Good translational research is needed, combining the skills, backgrounds and visions of basic and clinical researchers. The Reproductive Biology and Perinatal Lab (RBPL) has a great mix of projects and includes clinical and basic researchers. The fibroid research within the lab embraces an entirely new direction in thinking about uterine fibroids. We are looking at fibroids as more than neoplasms, and consider them to be a fibrotic disease. I also love teaching and believe that it happens not only in the classroom but also in the laboratory. Our group works hard to invite and accommodate students, residents, and fellows. We teach not only methods and procedures, but also approaches, limitations and design of experiments in hypothesis driven research. This knowledge and experience will serve any future researcher and clinician well when reading the literature, asking their own questions, and during collaborations. As a team, we are on our way to make a difference in woman’s health.
Education and Training
- Ph.D., North Carolina State University, 1995
- D.V.M., Justus Liebig University Giessen (Germany), 1987
Selected Grants and Awards
Whaley, SL, Hedgpeth, VS, Farin, CE, Martus, NS, Jayes, FC, and Britt, JH. "Influence of vitamin A injection before mating on oocyte development, follicular hormones, and ovulation in gilts fed high-energy diets." Journal of animal science 78, no. 6 (June 2000): 1598-1607.
Aguirre, C, Jayes, FC, and Veldhuis, JD. "Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH." Endocrinology 141, no. 6 (June 2000): 2220-2228.
Garmey, JC, Schnorr, JA, Bruns, ME, Bruns, DE, Seaner, RM, Ferguson II, JE, Luking Jayes, FC, Aguirre, C, and Veldhuis, JD. "Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells." Biology of reproduction 62, no. 2 (February 2000): 334-339.
Jayes, FC, Britt, JH, and Esbenshade, KL. "Role of gonadotropin-releasing hormone pulse frequency in differential regulation of gonadotropins in the gilt." Biology of reproduction 56, no. 4 (April 1997): 1012-1019.
JAYES, FL, MILLER, WL, and BRITT, JH. "INHIBIN ALTERS LH-RELEASE AND FSH-RELEASE FROM PERIFUSED PORCINE PITUITARY-CELLS PULSED WITH GNRH." 1995.
Heit, MC, Monteiro-Riviere, NA, Jayes, FL, and Riviere, JE. "Transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH): effect of repeated administration." Pharm Res 11, no. 7 (July 1994): 1000-1003.
Heit, MC, Williams, PL, Jayes, FL, and Chang, SK. Erratum: Transdermal iontophoretic peptide delivery: In vitro and in vivo studies with luteinizing hormone releasing hormone (Journal of Pharmaceutical Sciences (1993) 82 (240-243)). December 15, 1993.
HEIT, MC, WILLIAMS, PL, JAYES, FL, CHANG, SK, and RIVIERE, JE. "TRANSDERMAL IONTOPHORETIC PEPTIDE DELIVERY - INVITRO AND INVIVO STUDIES WITH LUTEINIZING-HORMONE-RELEASING HORMONE (VOL 82, PG 240, 1993)." JOURNAL OF PHARMACEUTICAL SCIENCES 82, no. 5 (May 1993): U554-U558.
Heit, MC, Williams, PL, Jayes, FL, Chang, SK, and Riviere, JE. "Transdermal iontophoretic peptide delivery: in vitro and in vivo studies with luteinizing hormone releasing hormone." J Pharm Sci 82, no. 5 (May 1993): 240-243.