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Laura Jean Havrilesky, MD

Laura Havirlesky, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-0188
Email: havri001@mc.duke.edu

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.

Education and Training

  • Residency, Obstetrics And Gynecology, Duke University, 1995 - 1999
  • M.D., Duke University, 1995

Research

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer.

The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women. 

Publications

Zhang, Z, Yu, Y, Xu, F, Berchuck, A, van Haaften-Day, C, Havrilesky, LJ, de Bruijn, HWA, van der Zee, AGJ, Woolas, RP, Jacobs, IJ, Skates, S, Chan, DW, and Bast, RC. "Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer." Gynecol Oncol 107, no. 3 (December 2007): 526-531.

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Jewell, EL, Kulasingam, S, Myers, ER, Alvarez Secord, A, and Havrilesky, LJ. "Primary surgery versus chemoradiation in the treatment of IB2 cervical carcinoma: a cost effectiveness analysis." Gynecol Oncol 107, no. 3 (December 2007): 532-540.

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Havrilesky, LJ, Secord, AA, Kulasingam, S, and Myers, E. "Management of platinum-sensitive recurrent ovarian cancer: a cost-effectiveness analysis." Gynecol Oncol 107, no. 2 (November 2007): 211-218.

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Alvarez Secord, A, Havrilesky, LJ, Bae-Jump, V, Chin, J, Calingaert, B, Bland, A, Rutledge, TL, Berchuck, A, Clarke-Pearson, DL, and Gehrig, PA. "The role of multi-modality adjuvant chemotherapy and radiation in women with advanced stage endometrial cancer." Gynecol Oncol 107, no. 2 (November 2007): 285-291.

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Rankins, NC, Secord, AA, Jewell, E, Havrilesky, LJ, Soper, JT, and Myers, E. "Cost-effectiveness of adjuvant radiotherapy in intermediate risk endometrial cancer." Gynecol Oncol 106, no. 2 (August 2007): 388-393.

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Secord, AA, Darcy, KM, Hutson, A, Lee, PS, Havrilesky, LJ, Grace, LA, Berchuck, A, and Gynecologic Oncology Group study, . "Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study." Gynecol Oncol 106, no. 1 (July 2007): 221-232.

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Huh, WK, Straughn, JM, Mariani, A, Podratz, KC, Havrilesky, LJ, Alvarez-Secord, A, Gold, MA, McMeekin, DS, Modesitt, S, Cooper, AL, Powell, MA, Mutch, DG, Nag, S, Alvarez, RD, and Cohn, DE. "Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience." Int J Gynecol Cancer 17, no. 4 (July 2007): 886-889.

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Havrilesky, LJ, Secord, AA, Bae-Jump, V, Ayeni, T, Calingaert, B, Clarke-Pearson, DL, Berchuck, A, and Gehrig, PA. "Outcomes in surgical stage I uterine papillary serous carcinoma." Gynecol Oncol 105, no. 3 (June 2007): 677-682.

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Cohn, DE, Woeste, EM, Cacchio, S, Zanagnolo, VL, Havrilesky, LJ, Mariani, A, Podratz, KC, Huh, WK, Whitworth, JM, McMeekin, DS, Powell, MA, Boyd, E, Phillips, GS, and Fowler, JM. "Clinical and pathologic correlates in surgical stage II endometrial carcinoma." Obstet Gynecol 109, no. 5 (May 2007): 1062-1067.

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Havrilesky, LJ, Cragun, JM, Calingaert, B, Alvarez Secord, A, Valea, FA, Clarke-Pearson, DL, Berchuck, A, and Soper, JT. "The prognostic significance of positive peritoneal cytology and adnexal/serosal metastasis in stage IIIA endometrial cancer." Gynecol Oncol 104, no. 2 (February 2007): 401-405.

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