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Laura Jean Havrilesky, MD

Laura Havirlesky, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-0188
Email: havri001@mc.duke.edu

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.

Education and Training

  • Residency, Obstetrics And Gynecology, Duke University, 1995 - 1999
  • M.D., Duke University, 1995

Research

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer.

The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women. 

Publications

McElligott, KA, Havrilesky, LJ, and Myers, ER. "Preoperative screening strategies for bacterial vaginosis prior to elective hysterectomy: a cost comparison study." American Journal of Obstetrics and Gynecology 205, no. 5 (November 2011): 500.e1-500.e7.

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Alvarez Secord, A, Darcy, KM, Hutson, A, Huang, Z, Lee, PS, Jewell, EL, Havrilesky, LJ, Markman, M, Muggia, F, and Murphy, SK. "The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study." Gynecol Oncol 123, no. 2 (November 2011): 314-319.

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Convery, PA, Cantrell, LA, Di Santo, N, Broadwater, G, Modesitt, SC, Secord, AA, and Havrilesky, LJ. "Retrospective review of an intraoperative algorithm to predict lymph node metastasis in low-grade endometrial adenocarcinoma." Gynecol Oncol 123, no. 1 (October 2011): 65-70.

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Teoh, D, Berchuck, A, Alvarez Secord, A, Lee, PS, Lowery, WJ, Sfakianos, GP, Valea, FA, Myers, ER, and Havrilesky, LJ. "Cost comparison of strategies for the management of venous thromboembolic event risk following laparotomy for ovarian cancer." Gynecol Oncol 122, no. 3 (September 2011): 467-472.

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Barnett, JC, Havrilesky, LJ, Bondurant, AE, Fleming, ND, Lee, PS, Secord, AA, Berchuck, A, and Valea, FA. "Adverse events associated with laparoscopy vs laparotomy in the treatment of endometrial cancer." Am J Obstet Gynecol 205, no. 2 (August 2011): 143.e1-143.e6.

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Jewell, EL, Smrtka, M, Broadwater, G, Valea, F, Davis, DM, Nolte, KC, Valea, R, Myers, ER, Samsa, G, and Havrilesky, LJ. "Utility scores and treatment preferences for clinical early-stage cervical cancer." Value in Health 14, no. 4 (June 2011): 582-586.

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Havrilesky, LJ, Hanna, RK, Poniewierski, MS, Laskey, R, Secord, AA, Gehrig, PA, Lopez, MA, Shafer, A, Van Le, L, Dale, DC, Crawford, J, and Lyman, GH. "Relationship between relative dose intensity and mortality in women receiving combination chemotherapy for stage III-IV epithelial ovarian cancer." May 20, 2011.

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Havrilesky, LJ, Hanna, RK, Poniewierski, MS, Laskey, R, Secord, AA, Gehrig, PA, Lopez, MA, Shafer, A, Van Le, L, Dale, DC, Crawford, J, and Lyman, GH. "Relationship between relative dose intensity and mortality in women receiving combination chemotherapy for stage III-IV epithelial ovarian cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 29, no. 15_suppl (May 2011): 5084-.

Scholars@Duke

Havrilesky, LJ, Sanders, GD, Kulasingam, S, Chino, JP, Berchuck, A, Marks, JR, and Myers, ER. "Development of an ovarian cancer screening decision model that incorporates disease heterogeneity: implications for potential mortality reduction." Cancer 117, no. 3 (February 1, 2011): 545-553.

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Sfakianos, GP, and Havrilesky, LJ. "A review of cost-effectiveness studies in ovarian cancer." Cancer Control 18, no. 1 (January 2011): 59-64. (Review)

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