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Laura Jean Havrilesky, MD

Laura Havirlesky, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-0188
Email: havri001@mc.duke.edu

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.

Education and Training

  • Residency, Obstetrics And Gynecology, Duke University, 1995 - 1999
  • M.D., Duke University, 1995

Research

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer.

The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women. 

Publications

Judd, JP, Siddiqui, NY, Barnett, JC, Visco, AG, Havrilesky, LJ, and Wu, JM. "Cost-minimization analysis of robotic-assisted, laparoscopic, and abdominal sacrocolpopexy." Journal of Minimally Invasive Gynecology 17, no. 4 (July 2010): 493-499.

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Jewell, EL, Darcy, KM, Hutson, A, Lee, PS, Havrilesky, LJ, Grace, LA, Berchuck, A, and Secord, AA. "Association between the N-terminally truncated (DeltaN) p63alpha (DeltaNp63alpha) isoform and debulking status, VEGF expression and progression-free survival in previously untreated, advanced stage epithelial ovarian cancer: A Gynecologic Oncology Group study." Gynecologic Oncology 115, no. 3 (December 2009): 424-429.

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Fader, AN, Starks, D, Gehrig, PA, Secord, AA, Frasure, HE, O'Malley, DM, Tuller, ER, Rose, PG, Havrilesky, LJ, Moore, KN, Huh, WK, Axtell, AE, Kelley, JL, Zanotti, KM, and UPSC Consortium, . "An updated clinicopathologic study of early-stage uterine papillary serous carcinoma (UPSC)." Gynecol Oncol 115, no. 2 (November 2009): 244-248.

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Lee, PS, Bland, A, Valea, FA, Havrilesky, LJ, Berchuck, A, and Secord, AA. "Robotic-assisted laparoscopic gynecologic procedures in a fellowship training program." Jsls : Journal of the Society of Laparoendoscopic Surgeons 13, no. 4 (October 2009): 467-472.

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Secord, AA, Havrilesky, LJ, O'Malley, DM, Bae-Jump, V, Fleming, ND, Broadwater, G, Cohn, DE, and Gehrig, PA. "A multicenter evaluation of sequential multimodality therapy and clinical outcome for the treatment of advanced endometrial cancer." Gynecologic Oncology 114, no. 3 (September 2009): 442-447.

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Havrilesky, LJ, Secord, AA, O'Malley, DM, Broadwater, G, Bae-Jump, V, Cohn, DE, and Gehrig, PA. "Multicenter analysis of recurrence and survival in stage IIIA endometrial cancer." Gynecol Oncol 114, no. 2 (August 2009): 279-283.

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Bernardini, MQ, May, T, Khalifa, MA, Bland, AE, Nofech-Mozes, S, Berchuck, A, Covens, A, and Havrilesky, L. "Evaluation of two management strategies for preoperative grade 1 endometrial cancer." Obstet Gynecol 114, no. 1 (July 2009): 7-15.

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Havrilesky, LJ, Maxwell, GL, and Myers, ER. "Cost-effectiveness analysis of annual screening strategies for endometrial cancer." American Journal of Obstetrics and Gynecology 200, no. 6 (June 2009): 640.e1-640.e8.

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Fader, AN, Rose, PG, Frasure, H, Gehrig, PA, Moore, KN, Havrilesky, LJ, Huh, WK, Axtell, AE, O'Malley, DM, and Zanotti, M. "Can primary recurrences in surgical stage I-II uterine papillary serous carcinoma (UPSC) patients be salvaged?." 45th Annual Meeting of the American-Society-of-Clinical-Oncology. Orlando, FL. May 29, 2009 - June 2, 2009.: AMER SOC CLINICAL ONCOLOGY, May 20, 2009.

Scholars@Duke

Fader, AN, Drake, RD, O'Malley, DM, Gibbons, HE, Huh, WK, Havrilesky, LJ, Gehrig, PA, Tuller, E, Axtell, AE, Zanotti, KM, and Uterine Papillary Serous Carcinoma (UPSC) Consortium, . "Platinum/taxane-based chemotherapy with or without radiation therapy favorably impacts survival outcomes in stage I uterine papillary serous carcinoma." Cancer 115, no. 10 (May 15, 2009): 2119-2127.

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