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Laura Jean Havrilesky, MD

Laura Havirlesky, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-0188
Email: havri001@mc.duke.edu

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.

Education and Training

  • Residency, Obstetrics And Gynecology, Duke University, 1995 - 1999
  • M.D., Duke University, 1995

Research

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer.

The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women. 

Publications

Ehrisman, J, Secord, AA, Berchuck, A, Lee, PS, Di Santo, N, Lopez-Acevedo, M, Broadwater, G, Valea, FA, and Havrilesky, LJ. "Performance of sentinel lymph node biopsy in high-risk endometrial cancer." Gynecologic oncology reports 17 (August 2016): 69-71.

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Davidson, BA, Foote, J, Clark, LH, Broadwater, G, Ehrisman, J, Gehrig, P, Graybill, W, Alvarez Secord, A, and Havrilesky, LJ. "Tumor grade and chemotherapy response in endometrioid endometrial cancer." Gynecologic oncology reports 17 (August 2016): 3-6.

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Wallbillich, JJ, Forde, B, Havrilesky, LJ, and Cohn, DE. "A personalized paradigm in the treatment of platinum-resistant ovarian cancer - A cost utility analysis of genomic-based versus cytotoxic therapy." Gynecologic oncology 142, no. 1 (July 2016): 144-149.

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Phippen, NT, Havrilesky, LJ, Barnett, JC, Hamilton, CA, Stany, MP, and Lowery, WJ. "Does Routine Posttreatment PET/CT Add Value to the Care of Women With Locally Advanced Cervical Cancer?." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 26, no. 5 (June 2016): 944-950.

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Secord, AA, and Havrilesky, LJ. "Is Intraperitoneal Chemotherapy Dead?." Obstetrics and gynecology 127, no. 6 (June 2016): 983-984.

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Secord, AA, Hasselblad, V, Von Gruenigen, VE, Gehrig, PA, Modesitt, SC, Bae-Jump, V, and Havrilesky, LJ. "Body mass index and mortality in endometrial cancer: A systematic review and meta-analysis." Gynecologic oncology 140, no. 1 (January 2016): 184-190. (Review)

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Merk, BA, Havrilesky, LJ, Ehrisman, JA, Broadwater, G, and Habib, AS. "Impact of postoperative nausea and vomiting prophylaxis with dexamethasone on the risk of recurrence of endometrial cancer." Current medical research and opinion 32, no. 3 (January 2016): 453-458.

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Hess, LM, Huang, HQ, Hanlon, AL, Robinson, WR, Johnson, R, Chambers, SK, Mannel, RS, Puls, L, Davidson, SA, Method, M, Lele, S, Havrilesky, L, Nelson, T, and Alberts, DS. "Cognitive function during and six months following chemotherapy for front-line treatment of ovarian, primary peritoneal or fallopian tube cancer: An NRG oncology/gynecologic oncology group study." Gynecologic oncology 139, no. 3 (December 2015): 541-545.

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Dickson, EL, Vogel, RI, Gehrig, PA, Pierce, S, Havrilesky, L, Secord, AA, Dottino, J, Fader, AN, Ricci, S, and Geller, MA. "A multi-institutional study of outcomes in stage I-III uterine carcinosarcoma." Gynecologic oncology 139, no. 2 (November 2015): 275-282.

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Myers, ER, Moorman, P, Gierisch, JM, Havrilesky, LJ, Grimm, LJ, Ghate, S, Davidson, B, Mongtomery, RC, Crowley, MJ, McCrory, DC, Kendrick, A, and Sanders, GD. "Benefits and Harms of Breast Cancer Screening: A Systematic Review." JAMA 314, no. 15 (October 2015): 1615-1634. (Review)

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