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Laura Jean Havrilesky, MD

Laura Havirlesky, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-0188
Email: havri001@mc.duke.edu

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.

Education and Training

  • Residency, Obstetrics And Gynecology, Duke University, 1995 - 1999
  • M.D., Duke University, 1995

Research

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer.

The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women. 

Publications

Berchuck, A, Havrilesky, LJ, and Kauff, ND. "Is There a Role for Ovarian Cancer Screening in High-Risk Women?." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 35, no. 13 (May 2017): 1384-1386.

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Natesan, D, Hong, JC, Foote, J, Sosa, JA, Havrilesky, L, and Chino, J. "Primary Versus Preoperative Radiation for Locally Advanced Vulvar Cancer." International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society 27, no. 4 (May 2017): 794-804.

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Cohn, DE, Ko, E, Meyer, LA, Wright, JD, Temkin, SM, Foote, J, Jones, NL, and Havrilesky, LJ. "The "value" of value in gynecologic oncology practice in the United States: Society of Gynecologic Oncology evidence-based review and recommendations." Gynecologic oncology 145, no. 1 (April 2017): 185-191. (Review)

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Pierce, SR, Stine, JE, Gehrig, PA, Havrilesky, LJ, Secord, AA, Nakayama, J, Snavely, AC, Moore, DT, and Kim, KH. "Prior breast cancer and tamoxifen exposure does not influence outcomes in women with uterine papillary serous carcinoma." Gynecologic Oncology 144, no. 3 (March 2017): 531-535.

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Foote, JR, Lopez-Acevedo, M, Buchanan, AH, Secord, AA, Lee, PS, Fountain, C, Myers, ER, Cohn, DE, Reed, SD, and Havrilesky, LJ. "Cost Comparison of Genetic Testing Strategies in Women With Epithelial Ovarian Cancer." Journal of Oncology Practice 13, no. 2 (February 2017): e120-e129.

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Foote, JR, Lopez-Acevedo, M, Buchanan, AH, Secord, AA, Lee, PS, Fountain, C, Myers, ER, Cohn, DE, Reed, SD, and Havrilesky, LJ. "Cost Comparison of Genetic Testing Strategies in Women With Epithelial Ovarian Cancer." Journal of oncology practice 13, no. 2 (February 2017): e120-e129.

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Foote, JR, Gaillard, S, Broadwater, G, Sosa, JA, Davidson, B, Adam, MA, Secord, AA, Jones, MB, Chino, J, and Havrilesky, LJ. "Disparities in the surgical staging of high-grade endometrial cancer in the United States." Gynecologic Oncology Research and Practice 4 (January 19, 2017): 1-null.

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Miller, CR, Chappell, NP, Sledge, C, Leath, CA, Phippen, NT, Havrilesky, LJ, and Barnett, JC. "Are different methotrexate regimens as first line therapy for low risk gestational trophoblastic neoplasia more cost effective than the dactinomycin regimen used in GOG 0174?." Gynecologic oncology 144, no. 1 (January 2017): 125-129.

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Lee, PS, Kempner, S, Miller, M, Dominguez, J, Grotegut, C, Ehrisman, J, Previs, R, Havrilesky, LJ, Broadwater, G, Ellestad, SC, and Secord, AA. "Multidisciplinary approach to manage antenatally suspected placenta percreta: updated algorithm and patient outcomes." Gynecologic oncology research and practice 4 (January 2017): 11-.

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Natesan, D, Susko, M, Havrilesky, L, and Chino, J. "Definitive Chemoradiotherapy for Vulvar Cancer." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 26, no. 9 (November 2016): 1699-1705.

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