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Laura Jean Havrilesky, MD

Laura Havirlesky, MD
Professor of Obstetrics and Gynecology
Campus Mail: 25172 Morris Bldg, Durham, NC 27710
Phone: (919) 684-0188
Email: havri001@mc.duke.edu

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer. The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women.

Education and Training

  • Residency, Obstetrics And Gynecology, Duke University, 1995 - 1999
  • M.D., Duke University, 1995

Research

I am interested in using health economic models to inform decisions related to gynecologic cancers. Specific models have addressed the decision to administer intraperitoneal chemotherapy for newly diagnosed advanced ovarian cancer following optimal cytoreduction, the choice of chemotherapy regimen for recurrent platinum-sensitive ovarian cancer, and the exploration of screening strategies for ovarian cancer.

The ovarian cancer screening model examines the effects of test cost, sensitivity, specificity, and screen frequency on ovarian cancer mortality, the lifetime false positive rate of testing, the positive predictive value of the test, and its cost effectiveness. This type of model is potentially useful in informing the design trials of novel screening tests for ovarian cancer. I am also conducting a prospective study to quantify the effects of screening for, diagnosis of, and treatment for ovarian cancer on the quality of life of women. 

Publications

Davidson, BA, Squatrito, R, Duska, LR, Havrilesky, LJ, Schwager, N, McCollum, M, Arapovic, S, and Secord, AA. "Phase II evaluation of nintedanib in the treatment of bevacizumab-resistant persistent/recurrent ovarian, fallopian tube, or primary peritoneal carcinoma." May 20, 2016.

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Bush, SH, Tollin, S, Marchion, DC, Xiong, Y, Abbasi, F, Ramirez, IJ, Zgheib, NB, Boac, B, Judson, PL, Chon, HS, Wenham, RM, Apte, SM, Cubitt, CL, Berglund, AE, Havrilesky, LJ, and Lancaster, JM. "Sensitivity of ovarian cancer cells to acetaminophen reveals biological pathways that affect patient survival." Molecular and Clinical Oncology 4, no. 3 (March 2016): 399-404.

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Ehrisman, JA, Abbott, S, Harmon, Z, Secord, AA, Berchuck, A, Lee, PS, Valea, FA, Broadwater, G, Li, X, Havrilesky, LJ, and Hall, A. "Prospective Evaluation of Lymph Node Processing at Staging Surgery for High-Grade Endometrial Cancer." February 2016.

Scholars@Duke

Davidson, BA, Foote, J, Brower, SL, Tian, C, Havrilesky, LJ, and Secord, AA. "Analysis of in vitro chemoresponse assays in endometrioid endometrial adenocarcinoma: an observational ancillary analysis." Gynecologic oncology research and practice 3 (January 2016): 13-.

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Secord, AA, Hasselblad, V, Von Gruenigen, VE, Gehrig, PA, Modesitt, SC, Bae-Jump, V, and Havrilesky, LJ. "Body mass index and mortality in endometrial cancer: A systematic review and meta-analysis." Gynecologic oncology 140, no. 1 (January 2016): 184-190. (Review)

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Merk, BA, Havrilesky, LJ, Ehrisman, JA, Broadwater, G, and Habib, AS. "Impact of postoperative nausea and vomiting prophylaxis with dexamethasone on the risk of recurrence of endometrial cancer." Current medical research and opinion 32, no. 3 (January 2016): 453-458.

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Hess, LM, Huang, HQ, Hanlon, AL, Robinson, WR, Johnson, R, Chambers, SK, Mannel, RS, Puls, L, Davidson, SA, Method, M, Lele, S, Havrilesky, L, Nelson, T, and Alberts, DS. "Cognitive function during and six months following chemotherapy for front-line treatment of ovarian, primary peritoneal or fallopian tube cancer: An NRG oncology/gynecologic oncology group study." Gynecologic oncology 139, no. 3 (December 2015): 541-545.

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Dickson, EL, Vogel, RI, Gehrig, PA, Pierce, S, Havrilesky, L, Secord, AA, Dottino, J, Fader, AN, Ricci, S, and Geller, MA. "A multi-institutional study of outcomes in stage I-III uterine carcinosarcoma." Gynecologic oncology 139, no. 2 (November 2015): 275-282.

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Myers, ER, Moorman, P, Gierisch, JM, Havrilesky, LJ, Grimm, LJ, Ghate, S, Davidson, B, Mongtomery, RC, Crowley, MJ, McCrory, DC, Kendrick, A, and Sanders, GD. "Benefits and Harms of Breast Cancer Screening: A Systematic Review." JAMA 314, no. 15 (October 2015): 1615-1634. (Review)

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Neff, R, Havrilesky, LJ, Chino, J, O'Malley, DM, and Cohn, DE. "Bariatric surgery as a means to decrease mortality in women with type I endometrial cancer - An intriguing option in a population at risk for dying of complications of metabolic syndrome." Gynecologic oncology 138, no. 3 (September 2015): 597-602.

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