Pham, Angela, Jun Zhang, and Liping Feng. “Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast.” Reprod Toxicol 98 (December 2020): 269–77. https://doi.org/10.1016/j.reprotox.2020.10.013.
Liping Feng, MD
Liping Feng, MD's research has focused on understanding the mechanisms of pregnancy complications associated with placental development. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.
Dr. Feng devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of placenta-originated pregnancy complications such as preeclampsia and still birth, which are important causes of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, cell aging, and environmental exposure in placental development and subsequent pregnancy complications.
In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.
Education and Training
- M.S., Chinese Center for Disease Control and Prevention (China), 2000
- M.D., Harbin Medical University (China), 1997
Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures
Investigating the impact of E-waste recycling and birth outcomes in China (Global health)
Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission
Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy
Selected Grants and Awards
- Effects of PFBS exposure on adverse pregnancy outcomes and fetal development
- Cellular and Molecular Systems Biology of Preterm Birth
- Mechanisms of Progesterone mediated effect on cytokine induced Metalloproteinase activity in human trophoblast cells
- Progesterone Receptor Membrane Component 1 (PGRMC1) as a Predictor of Preterm Birth
- SAFETY AND IMMUNOGENICITY OF TDAP VACCINE IN HEALTHY PREGNANT WOMEN, SAFETY IN THEIR NEONATES, AND EFFECT OF MATERNAL IMMUNIZATION ON INFANT IMMUNE RESPONSES TO DTAP VACCINE - DMID 05-0048
- DMID 09-0005 Safety and Immunogenicity
- 09-0056 A Phase II Study in Pregnant Women to Assess the Safety and Immunogenicity of an Unadjuvanted Sanofi Pasteur H1N1 Inactivated Influenza Vaccine Administered at Two Dose Levels
- A randomized double-blind trial on the safety and immunogenicity of inactivated trivalent influenza vaccine in pregnant women.
Marinello, William P., Zahra S. Mohseni, Sarah J. Cunningham, Christine Crute, Rong Huang, Jun J. Zhang, and Liping Feng. “Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.” Faseb J 34, no. 11 (November 2020): 14182–99. https://doi.org/10.1096/fj.202000716RR.
Huo, Xiaona, Lin Zhang, Rong Huang, Liping Feng, Weiye Wang, Jun Zhang, and Jun Shanghai Birth Cohort. “Perfluoroalkyl substances exposure in early pregnancy and preterm birth in singleton pregnancies: a prospective cohort study.” Environ Health 19, no. 1 (June 3, 2020): 60. https://doi.org/10.1186/s12940-020-00616-8.
Huo, Xiaona, Rong Huang, Yuexin Gan, Kai Luo, Ruxianguli Aimuzi, Min Nian, Junjie Ao, et al. “Perfluoroalkyl substances in early pregnancy and risk of hypertensive disorders of pregnancy: A prospective cohort study.” Environ Int 138 (May 2020): 105656. https://doi.org/10.1016/j.envint.2020.105656.
Zhang, Yang, Trieu Le, Ryan Grabau, Zahra Mohseni, Hoejeong Kim, David R. Natale, Liping Feng, Hua Pan, and Huanghe Yang. “TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development.” Sci Adv 6, no. 19 (May 2020): eaba0310. https://doi.org/10.1126/sciadv.aba0310.
Zheng, Shaoling, Ruixin Li, Jiayu Liang, Zihao Wen, Xiuxia Huang, Xiuben Du, Shirui Dong, et al. “Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma.” Genet Test Mol Biomarkers 24, no. 4 (April 2020): 188–94. https://doi.org/10.1089/gtmb.2019.0147.
Xie, Xin, Congying Lu, Min Wu, Jiayu Liang, Yuting Ying, Kailiang Liu, Xiuxia Huang, et al. “Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013-2014).” Environ Int 136 (March 2020): 105445. https://doi.org/10.1016/j.envint.2019.105445.
Liu, Yongjie, Jun Zhang, and Liping Feng. “Intestinal Dysbacteriosis is Associated with the Imbalanced Cytokines Network in Unexplained Miscarriage.” In Reproductive Sciences, 27:205A-205A. SPRINGER HEIDELBERG, 2020.