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Liping Feng, MD

Property title
Associate Professor of Obstetrics and Gynecology
Campus Mail: 701 W Main St, Durham, NC 27701
Phone: (919) 613-1459
Email: feng0007@mc.duke.edu

Liping Feng, MD's research has focused on understanding the mechanisms of pregnancy complications associated with placental development. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Dr. Feng devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of placenta-originated pregnancy complications such as preeclampsia and still birth, which are important causes of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, cell aging, and environmental exposure in placental development and subsequent pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Education and Training

  • M.S., Chinese Center for Disease Control and Prevention (China), 2000
  • M.D., Harbin Medical University (China), 1997

Research

Projects

  • Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures

  • Investigating the impact of E-waste recycling and birth outcomes in China (Global health)

  • Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission

  • Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy

Publications

Marinello, William P., Zahra S. Mohseni, Sarah J. Cunningham, Christine Crute, Rong Huang, Jun J. Zhang, and Liping Feng. “Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.” Faseb J, September 9, 2020. https://doi.org/10.1096/fj.202000716RR.

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Aimuzi, Ruxianguli, Kai Luo, Rong Huang, Xiaona Huo, Min Nian, Fengxiu Ouyang, Yatao Du, et al. “Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy.” Environ Pollut 264 (September 2020): 114557. https://doi.org/10.1016/j.envpol.2020.114557.

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Huo, Xiaona, Lin Zhang, Rong Huang, Liping Feng, Weiye Wang, Jun Zhang, and Jun Shanghai Birth Cohort. “Perfluoroalkyl substances exposure in early pregnancy and preterm birth in singleton pregnancies: a prospective cohort study.” Environ Health 19, no. 1 (June 3, 2020): 60. https://doi.org/10.1186/s12940-020-00616-8.

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Huo, Xiaona, Rong Huang, Yuexin Gan, Kai Luo, Ruxianguli Aimuzi, Min Nian, Junjie Ao, et al. “Perfluoroalkyl substances in early pregnancy and risk of hypertensive disorders of pregnancy: A prospective cohort study.” Environ Int 138 (May 2020): 105656. https://doi.org/10.1016/j.envint.2020.105656.

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Zhang, Yang, Trieu Le, Ryan Grabau, Zahra Mohseni, Hoejeong Kim, David R. Natale, Liping Feng, Hua Pan, and Huanghe Yang. “TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development.” Sci Adv 6, no. 19 (May 2020): eaba0310. https://doi.org/10.1126/sciadv.aba0310.

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Zheng, Shaoling, Ruixin Li, Jiayu Liang, Zihao Wen, Xiuxia Huang, Xiuben Du, Shirui Dong, et al. “Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma.” Genet Test Mol Biomarkers 24, no. 4 (April 2020): 188–94. https://doi.org/10.1089/gtmb.2019.0147.

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Xie, Xin, Congying Lu, Min Wu, Jiayu Liang, Yuting Ying, Kailiang Liu, Xiuxia Huang, et al. “Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013-2014).” Environ Int 136 (March 2020): 105445. https://doi.org/10.1016/j.envint.2019.105445.

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Liu, Yongjie, Jun Zhang, and Liping Feng. “Intestinal Dysbacteriosis is Associated with the Imbalanced Cytokines Network in Unexplained Miscarriage.” In Reproductive Sciences, 27:205A-205A. SPRINGER HEIDELBERG, 2020.

Scholars@Duke

Marinello, William, Liping Feng, and Terrence K. Allen. “Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells.” Front Physiol 11 (2020): 900. https://doi.org/10.3389/fphys.2020.00900.

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