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Liping Feng, MD

Property title
Associate Professor of Obstetrics and Gynecology
Campus Mail: 303 Research Drive, 246 Sands, Durham, NC 27710
Phone: (919) 613-1459
Email: feng0007@mc.duke.edu

Liping Feng, MD's research has focused on understanding the mechanisms of pregnancy complications associated with placental development. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Dr. Feng devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of placenta-originated pregnancy complications such as preeclampsia and still birth, which are important causes of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, cell aging, and environmental exposure in placental development and subsequent pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Education and Training

  • M.S., Chinese Center for Disease Control and Prevention (China), 2000
  • M.D., Harbin Medical University (China), 1997

Research

Projects

  • Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures

  • Investigating the impact of E-waste recycling and birth outcomes in China (Global health)

  • Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission

  • Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy

Publications

Aimuzi, Ruxianguli, Kai Luo, Qian Chen, Hui Wang, Liping Feng, Fengxiu Ouyang, and Jun Zhang. “Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery..” Environ Int 130 (September 2019). https://doi.org/10.1016/j.envint.2019.104929.

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Huang, R., J. Zhu, L. Zhang, X. Hua, W. Ye, C. Chen, K. Sun, W. Wang, L. Feng, and J. Zhang. “Is ELABELA a reliable biomarker for hypertensive disorders of pregnancy?.” Pregnancy Hypertension 17 (July 1, 2019): 226–32. https://doi.org/10.1016/j.preghy.2019.06.007.

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Feng, Liping, Terrence K. Allen, William P. Marinello, and Amy P. Murtha. “Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells..” Reprod Sci 26, no. 3 (March 2019): 394–403. https://doi.org/10.1177/1933719118776790.

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Ye, Yunzhen, Yao Tang, Yu Xiong, Liping Feng, and Xiaotian Li. “Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2..” Faseb J 33, no. 2 (February 2019): 2732–42. https://doi.org/10.1096/fj.201800934RRR.

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Huang, Rong, Qian Chen, Lin Zhang, Kai Luo, Lin Chen, Shasha Zhao, Liping Feng, and Jun Zhang. “Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy..” Environ Health 18, no. 1 (January 9, 2019). https://doi.org/10.1186/s12940-018-0445-3.

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Jayes, Friederike L., Betty Liu, Liping Feng, Nydea Aviles-Espinoza, Sergey Leikin, and Phyllis C. Leppert. “Evidence of biomechanical and collagen heterogeneity in uterine fibroids..” Plos One 14, no. 4 (2019). https://doi.org/10.1371/journal.pone.0215646.

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Allen, Terrence K., Matthew N. Nazzal, Liping Feng, Irina A. Buhimschi, and Amy P. Murtha. “Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells..” Reprod Sci, November 19, 2018. https://doi.org/10.1177/1933719118811646.

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Ye, Jiangfeng, Yan Chen, Jing Zhu, Chang Chen, Xiaoyong Zhu, Liping Feng, Weiping Ye, and Jun Zhang. “Aspirin use during pregnancy and hypoxia-related placental pathology..” Pregnancy Hypertens 14 (October 2018): 177–88. https://doi.org/10.1016/j.preghy.2018.07.009.

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Feng, Liping, Terrence K. Allen, William P. Marinello, and Amy P. Murtha. “Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM)..” Am J Obstet Gynecol 219, no. 1 (July 2018): 101.e1-101.e12. https://doi.org/10.1016/j.ajog.2018.04.014.

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