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Liping Feng, MD

Assistant Professor of Obstetrics and Gynecology
Campus Mail: Box 103208, Durham, NC 27710
Phone: (919) 613-1459
Email: feng0007@mc.duke.edu

Education and Training

  • M.D., Harbin Medical University (China), 1997

Research

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Projects

  • Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures

  • Investigating the impact of E-waste recycling and birth outcomes in China (Global health)

  • Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission

  • Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy

Publications

Allen, T, Nazzal, M, Feng, L, Buhimschi, I, and Murtha, A. "The Role of PGRMC1 in Cytokine Induced MMP1, COX-2 and PGE(2) Expression in Amnion Mesenchymal Cells." March 2016.

Scholars@Duke

Potts, LC, Feng, L, Jayes, FL, and Murtha, AP. "341: Novel ex vivo system to evaluate inflammation of gestational membranes in response to U. parvum." January 2016.

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Feng, L, Ouyang, F, Liu, L, Wang, X, Wang, X, Li, Y-J, Murtha, A, Shen, H, Zhang, J, and Zhang, JJ. "Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai." Journal of environmental and public health 2016 (January 2016): 9416054-.

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Feng, L, Ransom, CE, Nazzal, MK, Allen, TK, Li, Y-J, Truong, T, Potts, LC, Seed, PC, and Murtha, AP. "The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection." PloS one 11, no. 12 (January 2016): e0168102-.

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Thompson, J, Feng, L, Antczak, B, Seed, P, and Murtha, A. "13: Inhibition of toll-like receptors and inflammatory response in primary chorion cells." December 2015.

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Allen, TK, Feng, L, Nazzal, M, Grotegut, CA, Buhimschi, IA, and Murtha, AP. "The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro." Anesthesia and analgesia 120, no. 5 (May 2015): 1085-1094.

Full Text

Feng, L, Allen, TK, Nazzal, MK, and Murtha, AP. "P4 and Progesterone Membrane Component 1 (PGRMC1) Inhibit Ureaplasma Parvum Induced Inflammation in Amnion and Chorion Cells." REPRODUCTIVE SCIENCES 22 (March 2015): 236A-237A.

Scholars@Duke

Feng, L, Allen, TK, and Murtha, AP. "Role of P4 and Progesterone Receptor Membrane Component 1 (PGRMC1) in Sirtuin1 and Sirtuin 3 Regulation in Chorion Cells Under Oxidative Stress." REPRODUCTIVE SCIENCES 22 (March 2015): 326A-326A.

Scholars@Duke

Huang, L, Liu, J, Feng, L, Chen, Y, Zhang, J, and Wang, W. "Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions." Placenta 35, no. 8 (August 2014): 563-569.

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Feng, L, Antczak, BC, Lan, L, Grotegut, CA, Thompson, JL, Allen, TK, and Murtha, AP. "Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)." Placenta 35, no. 5 (May 2014): 331-333.

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