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Liping Feng, MD

Assistant Professor of Obstetrics and Gynecology
Campus Mail: Box 103208, Durham, NC 27710
Phone: (919) 613-1459
Email: feng0007@mc.duke.edu

Education and Training

  • M.D., Harbin Medical University (China), 1997

Research

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Projects

  • Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures

  • Investigating the impact of E-waste recycling and birth outcomes in China (Global health)

  • Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission

  • Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy

Publications

Gunatilake, R, Yeh, J, Feng, L, Jayes, F, Leppert, P, Heine, RP, Murtha, A, and Grotegut, C. "An Elevated Leptin Obese Mouse Model Demonstrates Uterine Fibrosis and Decreased Uterine Contractility in Response to Oxytocin." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 195A-196A.

Scholars@Duke

Ransom, CE, Seed, PC, Fortner, KB, Feng, L, Lan, L, Yu, M, and Murtha, AP. "Differential Cytokine and Tissue Remodeling Responses in Chorion and Decidua Exposed to Ureaplasma parvum." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 362A-363A.

Scholars@Duke

Feng, L, Antczak, B, Thompson, J, Grotegut, CA, and Murtha, AP. "PGRMC1 Expression in Fetal Membrane Layers among Women with Preterm Premature Rupture of the Membranes (PPROM)." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 295A-295A.

Scholars@Duke

Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progestins Diminish Cytokine Induced MMP9 Activity in a Human Cytotrophoblast Cell Line Not Expressing the Nuclear Progesterone Receptor." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 294A-294A.

Scholars@Duke

Roeder, H, Jayes, F, Feng, L, and Leppert, PC. "CDB-4124 does not cause apoptosis in cultured fibroid cells." Reprod Sci 18, no. 9 (September 2011): 850-857.

Full Text

Fortner, KB, Ransom, CE, Canzoneri, BJ, Bentley, RC, Feng, L, Seed, PC, and Murtha, AP. "Bacteria Localization in Fetal Membranes among Subjects with Preterm Premature Rupture of Membranes." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 238A-238A.

Scholars@Duke

Feng, L, Grotegut, C, Schomberg, D, and Murtha, AP. "Progesterone Receptor Membrane Component 1 Mediated Signaling Inhibits Increase in Intracellular Ca2+ in Human Cytotrophoblast Cells." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 312A-313A.

Scholars@Duke

Grotegut, CA, Feng, L, Mao, L, Heine, RP, Murtha, AP, and Rockman, HA. "β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration." Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468-E477.

Full Text

Gunatilake, R, Feng, L, Swamy, G, Heine, RP, Murtha, A, and Grotegut, C. "Oxytocin receptor expression in uterine myometrium is not influenced by body mass index." January 2011.

Full Text

Murtha, A, Grotegut, C, Heine, RP, and Feng, L. "Progesterone receptor membrane component 1 (PGRMC1) inhibits Ca2+mediated cell death in human cytotrophoblast cells." January 2011.

Full Text

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