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Liping Feng, MD

Property title
Assistant Professor of Obstetrics and Gynecology
Campus Mail: 303 Research Drive, 246 Sands, Durham, NC 27710
Phone: (919) 613-1459
Email: feng0007@mc.duke.edu

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Education and Training

  • M.S., Chinese Center for Disease Control and Prevention (China), 2000
  • M.D., Harbin Medical University (China), 1997

Research

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Projects

  • Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures

  • Investigating the impact of E-waste recycling and birth outcomes in China (Global health)

  • Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission

  • Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy

Publications

Feng, L, Allen, TK, and Murtha, AP. "Role of P4 and Progesterone Receptor Membrane Component 1 (PGRMC1) in Sirtuin1 and Sirtuin 3 Regulation in Chorion Cells Under Oxidative Stress." REPRODUCTIVE SCIENCES 22 (March 1, 2015): 326A-326A.

Scholars@Duke

Huang, L, Liu, J, Feng, L, Chen, Y, Zhang, J, and Wang, W. "Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions." Placenta 35, no. 8 (August 2014): 563-569.

Full Text

Feng, L, Antczak, BC, Lan, L, Grotegut, CA, Thompson, JL, Allen, TK, and Murtha, AP. "Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)." Placenta 35, no. 5 (May 2014): 331-333.

Full Text

Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progesterone receptor membrane component 1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix metalloproteinase 9 activity in vitro." Reprod Sci 21, no. 2 (February 2014): 260-268.

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Fortner, KB, Grotegut, CA, Ransom, CE, Bentley, RC, Feng, L, Lan, L, Heine, RP, Seed, PC, and Murtha, AP. "Bacteria localization and chorion thinning among preterm premature rupture of membranes." Plos One 9, no. 1 (January 8, 2014): e83338-null.

Full Text

Thompson, J, Fortner, K, Antczak, B, Feng, L, Thomas, S, Grotegut, C, Seed, P, and Murtha, A. "791: Immunohistochemical distribution of toll-like receptors in human fetal membranes." January 2014.

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Kraus, DM, Feng, L, Heine, RP, Brown, HL, Caron, KM, Murtha, AP, and Grotegut, CA. "Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion." Reprod Sci 21, no. 1 (January 2014): 63-71.

Full Text

Grotegut, CA, Gunatilake, RP, Feng, L, Heine, RP, and Murtha, AP. "The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy." Reprod Sci 20, no. 12 (December 2013): 1471-1477.

Full Text

Canzoneri, BJ, Feng, L, Grotegut, CA, Bentley, RC, Heine, RP, and Murtha, AP. "The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes." Reprod Sci 20, no. 10 (October 2013): 1246-1254.

Full Text

Thompson, JL, Antczak, BC, Feng, L, Grotegut, CA, Seed, PC, and Murtha, AP. "Distribution of Toll-Like Receptor 4 in Preterm Fetal Membranes." 60th Annual Scientific Meeting of the Society-for-Gynecologic-Investigation (SGI). Orlando, FL. March 20, 2013 - March 23, 2013. SAGE PUBLICATIONS INC, March 1, 2013.

Scholars@Duke

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