Feng, L, Jayes, FL, Jung, S-H, and Leppert, PC. "VITAMIN D RECEPTOR (VDR) IS OVER-EXPRESSED IN THE CENTER OF UTERINE FIBROIDS." September 2010.
Liping Feng, MD
Education and Training
- M.D., Harbin Medical University (China), 1997
My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.
Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.
In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.
Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures
Investigating the impact of E-waste recycling and birth outcomes in China (Global health)
Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission
Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy
Selected Grants and Awards
Wu, J, Feng, L, and Hsieh, T-S. "Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells." Proc Natl Acad Sci U S A 107, no. 14 (April 6, 2010): 6228-6233.
Roeder, HA, Jayes, FL, Feng, L, and Leppert, PC. "Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells." March 2010.
Feng, L, and Murtha, AP. "R5020 Inhibits Calcium Ionophore-Induced Apoptosis in Trophoblast Cells by Regulating Intracellular Calcium." March 2010.
Johnson, LNC, Jayes, FL, Feng, L, and Leppert, PC. "Factors Involved in Early Uterine Fibroid Development: The Initiation of Early Wound Healing Responses in Myometrial Cells." 2010.
Beiswenger, T, Grotegut, C, Feng, L, Heine, P, and Murtha, A. "The effects of cigarette smoke on cell viability and angiogenic factors in a cytotrophoblast cell line." December 2009.
Jung, S-H, Sohn, I, George, SL, Feng, L, and Leppert, PC. "Sample size calculation for microarray experiments with blocked one-way design. (Published online)" BMC Bioinformatics 10 (May 28, 2009): 164-.
Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." March 2009.
Gavrilova-Jordan, LP, Zhang, L, Schomberg, D, Jayes, FL, Feng, L, and Price, TM. "Expression of a Truncated Progesterone Receptor (PR-M) Correlates with Mitochondrial Content in Human Tissues." March 2009.
Gavrilova-Jordan, LP, Schomberg, D, Feng, L, Jayes, FL, Murtha, A, and Price, TM. "Expression of a Truncated Progesterone Receptor Isoform (PR-M) in Pregnant and Laboring Myometrium." March 2009.