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Liping Feng, MD

Property title
Assistant Professor of Obstetrics and Gynecology
Campus Mail: 303 Research Drive, 246 Sands, Durham, NC 27710
Phone: (919) 613-1459
Email: feng0007@mc.duke.edu

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Education and Training

  • M.D., Harbin Medical University (China), 1997

Research

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Projects

  • Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures

  • Investigating the impact of E-waste recycling and birth outcomes in China (Global health)

  • Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission

  • Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy

Publications

Murtha, AP, Feng, L, Grotegut, C, and Schomberg, D. "Expression of COX2 and GPX2 Are Altered by Calcimycin but Not Progesterone in Fetal Chorion Cells." REPRODUCTIVE SCIENCES 16, no. 3 (March 2009): 295A-296A.

Scholars@Duke

Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium." March 2009.

Scholars@Duke

Jayes, FL, Proia, AD, Dash, RC, Feng, L, and Leppert, PC. "The Duke Uterine Fibroid Tissue Repository - A Stepping Stone for Translational Research." REPRODUCTIVE SCIENCES 16, no. 3 (March 2009): 210A-211A.

Scholars@Duke

Wu, J, Capp, C, Feng, L, and Hsieh, T-S. "Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development." Dev Biol 323, no. 1 (November 1, 2008): 130-142.

Full Text

Grotegut, CA, Canzoneri, BJ, Feng, L, Heine, P, and Murtha, AP. "Cigarette smoke extract causes cell death in cultured human chorion and decidua cells." February 2008.

Scholars@Duke

Feng, L, Behera, M, Jayes, F, and Leppert, P. "Uterine fibroids: Development of a cell model of early fibroid growth." February 2008.

Scholars@Duke

Behera, MA, Feng, L, Yonish, B, Catherino, W, Jung, S-H, and Leppert, P. "Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline (Reproductive Sciences (2007) 14, 8, (63S-76S) DOI: 10.1177/1933719107309591)." Reproductive Sciences 15, no. 1 (2008): 97--.

Full Text

Murtha, A, Feng, L, Yonish, B, Bone, J, Heine, P, and Schomberg, DW. "Progesterone causes altered proinflammatory, cytoprotective gene expression in fetal chorion cells." December 2007.

Full Text

Behera, MA, Feng, L, Yonish, B, Catherino, W, Jung, S-H, and Leppert, P. "Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline." Reprod Sci 14, no. 8 Suppl (December 2007): 63-76.

Full Text

Murtha, AP, Feng, L, Yonish, B, Leppert, PC, and Schomberg, DW. "Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death." Am J Obstet Gynecol 196, no. 3 (March 2007): 257.e1-257.e5.

Full Text

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