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Robert Phillips Heine, MD

Property title
Professor of Obstetrics and Gynecology
Campus Mail: 2608 Erwin Road, Suite 200, Durham, NC 27705
Phone: (919) 668-0843

Dr. R. Phillips Heine is a Professor of Obstetrics & Gynecology and Pediatrics at Duke University Medical Center in Durham, NC. He currently serves as the Director of the Division of Maternal-Fetal Medicine, Vice Chair for Administration Affairs, and Medical Director for the Women’s Clinical Services Unit (CSU) in the Duke University Health System.

Dr. Heine completed his clinical training in Obstetrics and Gynecology at the University of North Carolina during which time he developed an academic interest regarding infection and its role in women’s reproductive health and specifically adverse pregnancy outcome. He subsequently completed a Sexually Transmitted Diseases research fellowship in the laboratories of Fred Sparling and Priscilla Wyrick at the University of North Carolina and went on to complete a Maternal-Fetal Medicine fellowship at the University of Colorado. After fellowship Dr. Heine became a faculty member at the University of Pittsburgh and an investigator at the Magee Women’s Research Institute. During this time he served as Resident Research Coordinator and Associate MFM fellowship director prior to his move to Duke University.

His current clinical and research interests focus on the role of infection and inflammation in preterm birth and other adverse pregnancy outcomes. He also has a specific interest in the use of immunizations in pregnancy for both the prevention of disease in the mother and the newborn. 

Education and Training

  • Fellow, Obstetrics & Gynecology, University of Colorado at Boulder, 1991 - 1993
  • Fellow, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1990 - 1991
  • Resident, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1986 - 1990
  • M.D., Texas Tech University of Health Science Nursing, 1986
Vice Chair Discipline: 


Heine, RP, Wiesenfeld, HC, Sweet, RL, and Witkin, SS. "Polymerase chain reaction analysis of distal vaginal specimens: a less invasive strategy for detection of Trichomonas vaginalis." Clin Infect Dis 24, no. 5 (May 1997): 985-987.


Prieto, JA, Panyutich, AV, and Heine, RP. "Neutrophil activation in preeclampsia. Are defensins and lactoferrin elevated in preeclamptic patients?." J Reprod Med 42, no. 1 (January 1997): 29-32.


Gmblf, J, D'Abarno, J, and Heine, RP. "Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes?." Acta Diabetologica Latina 176, no. 1 PART II (1997): S34-.


Sunyecz, JA, Wiesenfeld, HC, and Phillip Heine, R. "A study of the pharmacokinetics of single daily dose gentamicin in women with post faktum endometritis." Infectious Diseases in Obstetrics and Gynecology 4, no. 1 (December 1, 1996): 50-51.


Phillip Heine, R, Heller, K, Mortimer, L, and Grieg, P. "Ammotic fluid defenses' levels are elevated in preterm labor patients with subclinical intra-amniotic infection." Infectious Diseases in Obstetrics and Gynecology 4, no. 1 (December 1, 1996): 48-.


Phillip Heine, R, Shumaker, B, Moyer, R, and Wiesenfeld, H. "ATP bioluminescence is an effective screening test for asymptomatic bacteriuria of pregnancy." Infectious Diseases in Obstetrics and Gynecology 4, no. 1 (December 1, 1996): 49-.


Draper, D, Donohoe, W, and Phillip Heine, R. "Secretory leukocyte protease inhibitor (slpi) in vaginal secretions is degraded by cysteine proteases of trichomonas vaginalis." Infectious Diseases in Obstetrics and Gynecology 4, no. 1 (December 1, 1996): 54-.


Wiesenfeld, HC, Phillip Heine, R, Panyuiich, A, Krohn, M, and Sweet, RL. "Vaginal defenslns as less-invasive markers for sexually transmitted diseases (STD)." Infectious Diseases in Obstetrics and Gynecology 4, no. 1 (December 1, 1996): 50-.


Cooperstock, M. "Mechanisms of preterm premature rupture of membranes." American journal of obstetrics and gynecology 174, no. 5 (May 1996): 1672-.

Full Text

Wiesenfeld, HC, Heine, RP, Rideout, A, Macio, I, DiBiasi, F, and Sweet, RL. "The vaginal introitus: a novel site for Chlamydia trachomatis testing in women." Am J Obstet Gynecol 174, no. 5 (May 1996): 1542-1546.