Berghella, V, Klebanoff, M, McPherson, C, Carey, JC, Hauth, JC, Ernest, JM, Heine, RP, Wapner, RJ, Trout, W, Moawad, A, Leveno, KJ, Miodovnik, M, Sibai, BM, Van Dorsten, JP, Dombrowski, MP, O'Sullivan, MJ, Varner, M, Langer, O, and National Institute for Child Health and Development Maternal Fetal Medicine Units Network, . "Sexual intercourse association with asymptomatic bacterial vaginosis and Trichomonas vaginalis treatment in relationship to preterm birth." American Journal of Obstetrics and Gynecology 187, no. 5 (November 2002): 1277-1282.
Robert Phillips Heine, MD
Dr. R. Phillips Heine is a Professor of Obstetrics & Gynecology and Pediatrics at Duke University Medical Center in Durham, NC. He currently serves as the Director of the Division of Maternal-Fetal Medicine, Vice Chair for Administration Affairs, and Medical Director for the Women’s Clinical Services Unit (CSU) in the Duke University Health System.
Dr. Heine completed his clinical training in Obstetrics and Gynecology at the University of North Carolina during which time he developed an academic interest regarding infection and its role in women’s reproductive health and specifically adverse pregnancy outcome. He subsequently completed a Sexually Transmitted Diseases research fellowship in the laboratories of Fred Sparling and Priscilla Wyrick at the University of North Carolina and went on to complete a Maternal-Fetal Medicine fellowship at the University of Colorado. After fellowship Dr. Heine became a faculty member at the University of Pittsburgh and an investigator at the Magee Women’s Research Institute. During this time he served as Resident Research Coordinator and Associate MFM fellowship director prior to his move to Duke University.
His current clinical and research interests focus on the role of infection and inflammation in preterm birth and other adverse pregnancy outcomes. He also has a specific interest in the use of immunizations in pregnancy for both the prevention of disease in the mother and the newborn.
Education and Training
- Fellow, Obstetrics & Gynecology, University of Colorado at Boulder, 1991 - 1993
- Fellow, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1990 - 1991
- Resident, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1986 - 1990
- M.D., Texas Tech University of Health Science Nursing, 1986
Selected Grants and Awards
- RTOP 2018 CISA 01 Flublok Lead Base
- RTOP 2018 CISA 01 Flublok Lead Task 1
- VTEU Task C Option 1 - FY.2017.B2C2D2.0053
- VTEU Task C Option 4 - FY.2017.B2C2D2.0053
- VTEU Task C Option 3 - FY.2017.B2C2D2.0053
- VTEU 12-0021 Task C - Base
- VTEU Task C Option 2 - FY.2017.B2C2D2.0053
- CISA: 2015 CISA 03 - Lead Site Base Task: Maternal Tdap and IIV Study (Lead)
- VTEU 12-0021 - Task C Option 1
- CISA Task Order No. 3 Tdap Safety in Pregnant Women
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
- Effectiveness of a Vaccination Program in the Community ObGyn Setting
- 09-0056 A Phase II Study in Pregnant Women to Assess H1N1 Vaccine
- A randomized double-blind trial on the safety and immunogenicity of inactivated trivalent influenza vaccine in pregnant
Wiesenfeld, HC, Heine, RP, Krohn, MA, Hillier, SL, Amortegui, AA, Nicolazzo, M, and Sweet, RL. "Association between elevated neutrophil defensin levels and endometritis." J Infect Dis 186, no. 6 (September 15, 2002): 792-797.
Wiesenfeld, HC, Hillier, SL, Krohn, MA, Amortegui, AJ, Heine, RP, Landers, DV, and Sweet, RL. "Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease." Obstet Gynecol 100, no. 3 (September 2002): 456-463.
Thomas, NJ, Carcillo, JA, Doughty, LA, Sasser, H, and Heine, RP. "Plasma concentrations of defensins and lactoferrin in children with severe sepsis." Pediatr Infect Dis J 21, no. 1 (January 2002): 34-38.
Klebanoff, MA, Carey, JC, Hauth, JC, Hillier, SL, Nugent, RP, Thom, EA, Ernest, JM, Heine, RP, Wapner, RJ, Trout, W, Moawad, A, Leveno, KJ, Miodovnik, M, Sibai, BM, Van Dorsten, JP, Dombrowski, MP, O'Sullivan, MJ, Varner, M, Langer, O, McNellis, D, Roberts, JM, and National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units, . "Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection." N Engl J Med 345, no. 7 (August 16, 2001): 487-493.
Wiesenfeld, HC, Lowry, DL, Heine, RP, Krohn, MA, Bittner, H, Kellinger, K, Shultz, M, and Sweet, RL. "Self-collection of vaginal swabs for the detection of Chlamydia, gonorrhea, and trichomoniasis: opportunity to encourage sexually transmitted disease testing among adolescents." Sex Transm Dis 28, no. 6 (June 2001): 321-325.
Draper, DL, Kush, MJ, Donohoe, W, Janosky, J, Latimer, JJ, and Heine, RP. "Preterm premature rupture of membranes without labor is not associated with increased levels of matrix metalloproteinase-9 protein." Prenatal and Neonatal Medicine 6, no. 4 (2001): 219-226.
Draper, DL, Landers, DV, Krohn, MA, Hillier, SL, Wiesenfeld, HC, and Heine, RP. "Levels of vaginal secretory leukocyte protease inhibitor are decreased in women with lower reproductive tract infections." Am J Obstet Gynecol 183, no. 5 (November 2000): 1243-1248.
Heine, RP, McGregor, JA, Goodwin, TM, Artal, R, Hayashi, RH, Robertson, PA, and Varner, MW. "Serial salivary estriol to detect an increased risk of preterm birth." Obstetrics and Gynecology 96, no. 4 (October 2000): 490-497.
Goldenberg, RL, Klebanoff, M, Carey, JC, Macpherson, C, Leveno, KJ, Moawad, AH, Sibai, B, Heine, RP, Ernest, JM, Dombrowski, MP, Miodovnik, M, Wapner, RJ, Iams, JD, Langer, O, O'sullivan, MJ, and Roberts, JM. "Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth." Am J Obstet Gynecol 183, no. 2 (August 2000): 469-475.