Skip to main content

Robert Phillips Heine, MD

Property title
Professor of Obstetrics and Gynecology
Campus Mail: 2608 Erwin Road, Suite 200, Durham, NC 27705
Phone: (919) 668-0843

Dr. R. Phillips Heine is a Professor of Obstetrics & Gynecology and Pediatrics at Duke University Medical Center in Durham, NC. He currently serves as the Director of the Division of Maternal-Fetal Medicine, Vice Chair for Administration Affairs, and Medical Director for the Women’s Clinical Services Unit (CSU) in the Duke University Health System.

Dr. Heine completed his clinical training in Obstetrics and Gynecology at the University of North Carolina during which time he developed an academic interest regarding infection and its role in women’s reproductive health and specifically adverse pregnancy outcome. He subsequently completed a Sexually Transmitted Diseases research fellowship in the laboratories of Fred Sparling and Priscilla Wyrick at the University of North Carolina and went on to complete a Maternal-Fetal Medicine fellowship at the University of Colorado. After fellowship Dr. Heine became a faculty member at the University of Pittsburgh and an investigator at the Magee Women’s Research Institute. During this time he served as Resident Research Coordinator and Associate MFM fellowship director prior to his move to Duke University.

His current clinical and research interests focus on the role of infection and inflammation in preterm birth and other adverse pregnancy outcomes. He also has a specific interest in the use of immunizations in pregnancy for both the prevention of disease in the mother and the newborn. 

Education and Training

  • Fellow, Obstetrics & Gynecology, University of Colorado at Boulder, 1991 - 1993
  • Fellow, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1990 - 1991
  • Resident, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1986 - 1990
  • M.D., Texas Tech University of Health Science Nursing, 1986
Vice Chair Discipline: 


Kraus, DM, Feng, L, Heine, RP, Brown, HL, Caron, KM, Murtha, AP, and Grotegut, CA. "Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion." Reprod Sci 21, no. 1 (January 2014): 63-71.

Full Text

Grotegut, CA, Kuklina, EV, Anstrom, KJ, Heine, RP, Callaghan, WM, Myers, ER, and James, AH. "Factors associated with the change in prevalence of cardiomyopathy at delivery in the period 2000-2009: A population-based prevalence study." BJOG: An International Journal of Obstetrics and Gynaecology 121, no. 11 (2014): 1386-1394.

Full Text

Grotegut, CA, Chisholm, CA, Johnson, LNC, Brown, HL, Heine, RP, and James, AH. "Medical and obstetric complications among pregnant women aged 45 and older." PloS one 9, no. 4 (January 2014): e96237-.

Full Text

Ahmadzia, HK, Heine, RP, and Brown, HL. "GBS screening: An update on guidelines and methods." Contemporary Ob/Gyn 58, no. 7 (December 1, 2013): 40-46.


Grotegut, CA, Gunatilake, RP, Feng, L, Heine, RP, and Murtha, AP. "The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy." Reprod Sci 20, no. 12 (December 2013): 1471-1477.

Full Text

Canzoneri, BJ, Feng, L, Grotegut, CA, Bentley, RC, Heine, RP, and Murtha, AP. "The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes." Reprod Sci 20, no. 10 (October 2013): 1246-1254.

Full Text

Munoz, FM, Sheffield, JS, Beigi, RH, Read, JS, Swamy, GK, Jevaji, I, Rasmussen, SA, Edwards, KM, Fortner, KB, Patel, SM, Spong, CY, Ault, K, Heine, RP, and Nesin, M. "Research on vaccines during pregnancy: protocol design and assessment of safety." Vaccine 31, no. 40 (September 13, 2013): 4274-4279.

Full Text

Sheffield, JS, Munoz, FM, Beigi, RH, Rasmussen, SA, Edwards, KM, Read, JS, Heine, RP, Ault, KA, Swamy, GK, Jevaji, I, Spong, CY, Fortner, KB, Patel, SM, and Nesin, M. "Research on vaccines during pregnancy: reference values for vital signs and laboratory assessments." Vaccine 31, no. 40 (September 13, 2013): 4264-4273.

Full Text

Kraus, D, Feng, L, Heine, RP, Brown, H, Murtha, A, and Grotegut, C. "43: Smoking and preeclamspia protection: cigarette smoke increases placental adrenomedullin expression and improves trophoblast invasion via the adrenomedullin pathway." January 2013.

Full Text

Dotters-Katz, SK, Kuller, J, and Heine, RP. "Arthropod-borne bacterial diseases in pregnancy." Obstetrical and Gynecological Survey 68, no. 9 (2013): 635-649.

Full Text