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Robert Phillips Heine, MD

Property title
Professor of Obstetrics and Gynecology
Campus Mail: 2608 Erwin Road, Suite 200, Durham, NC 27705
Phone: (919) 668-0843

Dr. R. Phillips Heine is a Professor of Obstetrics & Gynecology and Pediatrics at Duke University Medical Center in Durham, NC. He currently serves as the Director of the Division of Maternal-Fetal Medicine, Vice Chair for Administration Affairs, and Medical Director for the Women’s Clinical Services Unit (CSU) in the Duke University Health System.

Dr. Heine completed his clinical training in Obstetrics and Gynecology at the University of North Carolina during which time he developed an academic interest regarding infection and its role in women’s reproductive health and specifically adverse pregnancy outcome. He subsequently completed a Sexually Transmitted Diseases research fellowship in the laboratories of Fred Sparling and Priscilla Wyrick at the University of North Carolina and went on to complete a Maternal-Fetal Medicine fellowship at the University of Colorado. After fellowship Dr. Heine became a faculty member at the University of Pittsburgh and an investigator at the Magee Women’s Research Institute. During this time he served as Resident Research Coordinator and Associate MFM fellowship director prior to his move to Duke University.

His current clinical and research interests focus on the role of infection and inflammation in preterm birth and other adverse pregnancy outcomes. He also has a specific interest in the use of immunizations in pregnancy for both the prevention of disease in the mother and the newborn. 

Education and Training

  • Fellow, Obstetrics & Gynecology, University of Colorado at Boulder, 1991 - 1993
  • Fellow, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1990 - 1991
  • Resident, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1986 - 1990
  • M.D., Texas Tech University of Health Science Nursing, 1986
Vice Chair Discipline: 


Beiswenger, TR, Feng, L, Brown, HL, Heine, RP, Murtha, AP, and Grotegut, CA. "The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin." Reprod Sci 19, no. 5 (May 2012): 526-533.

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Gunatilake, R, and Heine, RP. "Trichomonas Vaginalis." In Sexually Transmitted Diseases, 64-71. April 11, 2012.

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Gunatilake, R, Yeh, J, Feng, L, Jayes, F, Leppert, P, Heine, RP, Murtha, A, and Grotegut, C. "An Elevated Leptin Obese Mouse Model Demonstrates Uterine Fibrosis and Decreased Uterine Contractility in Response to Oxytocin." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 195A-196A.


Ault, KA, Heine, RP, and Riley, LE. "Programmatic and research priorities for improving influenza immunization of pregnant women." American Journal of Obstetrics and Gynecology 207, no. 3 SUPPL. (2012): S75-S77.

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Dotters-Katz, S, Kuller, J, and Heine, RP. "Parasitic infections in pregnancy." Obstetrical & gynecological survey 66, no. 8 (August 2011): 515-525. (Review)

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Grotegut, CA, Johnson, LNC, Fitzpatrick, CB, Heine, RP, Swamy, GK, and Murtha, AP. "Bleeding per vaginam is associated with funisitis in women with preterm prelabour rupture of the fetal membranes." BJOG 118, no. 6 (May 2011): 735-740.

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Grotegut, CA, Feng, L, Mao, L, Heine, RP, Murtha, AP, and Rockman, HA. "β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration." Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468-E477.

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Gunatilake, R, Feng, L, Swamy, G, Heine, RP, Murtha, A, and Grotegut, C. "318: Oxytocin receptor expression in uterine myometrium is not influenced by body mass index." January 2011.

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Murtha, A, Grotegut, C, Heine, RP, and Feng, L. "46: Progesterone receptor membrane component 1 (PGRMC1) inhibits Ca2+ mediated cell death in human cytotrophoblast cells." January 2011.

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Ransom, CE, Chin, JR, Roeder, HA, Sinclair, TR, Heine, RP, and Murtha, AP. "The influence of prior obstetrical history on current 17-hydroxyprogesterone caproate use." J Pregnancy 2011 (2011): 286483-.

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