Draper, DL, Kush, MJ, Donohoe, W, Janosky, J, Latimer, JJ, and Heine, RP. "Preterm premature rupture of membranes without labor is not associated with increased levels of matrix metalloproteinase-9 protein." Prenatal and Neonatal Medicine 6, no. 4 (2001): 219-226.
Robert Phillips Heine, MD
Dr. R. Phillips Heine is a Professor of Obstetrics & Gynecology and Pediatrics at Duke University Medical Center in Durham, NC. He currently serves as the Director of the Division of Maternal-Fetal Medicine, Vice Chair for Administration Affairs, and Medical Director for the Women’s Clinical Services Unit (CSU) in the Duke University Health System.
Dr. Heine completed his clinical training in Obstetrics and Gynecology at the University of North Carolina during which time he developed an academic interest regarding infection and its role in women’s reproductive health and specifically adverse pregnancy outcome. He subsequently completed a Sexually Transmitted Diseases research fellowship in the laboratories of Fred Sparling and Priscilla Wyrick at the University of North Carolina and went on to complete a Maternal-Fetal Medicine fellowship at the University of Colorado. After fellowship Dr. Heine became a faculty member at the University of Pittsburgh and an investigator at the Magee Women’s Research Institute. During this time he served as Resident Research Coordinator and Associate MFM fellowship director prior to his move to Duke University.
His current clinical and research interests focus on the role of infection and inflammation in preterm birth and other adverse pregnancy outcomes. He also has a specific interest in the use of immunizations in pregnancy for both the prevention of disease in the mother and the newborn.
Education and Training
- Fellow, Obstetrics & Gynecology, University of Colorado at Boulder, 1991 - 1993
- Fellow, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1990 - 1991
- Resident, Obstetrics & Gynecology, North Carolina Memorial Hospital, 1986 - 1990
- M.D., Texas Tech University of Health Science Nursing, 1986
Selected Grants and Awards
Draper, DL, Landers, DV, Krohn, MA, Hillier, SL, Wiesenfeld, HC, and Heine, RP. "Levels of vaginal secretory leukocyte protease inhibitor are decreased in women with lower reproductive tract infections." Am J Obstet Gynecol 183, no. 5 (November 2000): 1243-1248.
Heine, RP, McGregor, JA, Goodwin, TM, Artal, R, Hayashi, RH, Robertson, PA, and Varner, MW. "Serial salivary estriol to detect an increased risk of preterm birth." Obstet Gynecol 96, no. 4 (October 2000): 490-497.
Goldenberg, RL, Klebanoff, M, Carey, JC, Macpherson, C, Leveno, KJ, Moawad, AH, Sibai, B, Heine, RP, Ernest, JM, Dombrowski, MP, Miodovnik, M, Wapner, RJ, Iams, JD, Langer, O, O'sullivan, MJ, and Roberts, JM. "Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth." Am J Obstet Gynecol 183, no. 2 (August 2000): 469-475.
Carey, JC, Klebanoff, MA, Hauth, JC, Hillier, SL, Thom, EA, Ernest, JM, Heine, RP, Nugent, RP, Fischer, ML, Leveno, KJ, Wapner, R, and Varner, M. "Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units." N Engl J Med 342, no. 8 (February 24, 2000): 534-540.
Maffei, FA, Heine, RP, Whalen, MJ, Mortimer, LF, and Carcillo, JA. "Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis." Pediatrics 103, no. 5 Pt 1 (May 1999): 987-992.
Kaplan, SS, Heine, RP, and Simmons, RL. "Defensins impair phagocytic killing by neutrophils in biomaterial-related infection." Infect Immun 67, no. 4 (April 1999): 1640-1645.
Kauffman, DE, Sutkin, G, Heine, RP, Watt-Morse, M, and Price, FV. "Metastatic complete hydatidiform mole with a surviving coexistent twin. A case report." J Reprod Med 44, no. 2 (February 1999): 131-134. (Review)
Heine, RP, McGregor, JA, and Dullien, VK. "Accuracy of salivary estriol testing compared to traditional risk factor assessment in predicting preterm birth." American Journal of Obstetrics and Gynecology 180, no. 1 III (1999): S214-S218.
Heine, RP, McGregor, JA, and Dullien, VK. "Accuracy of salivary estriol testing compared to traditional risk factor assessment in predicting preterm birth." Am J Obstet Gynecol 180, no. 1 Pt 3 (January 1999): S214-S218.