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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140; Duke PO Box 90534, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Maguire, Rachel L., John S. House, Dillon T. Lloyd, Harlyn G. Skinner, Terrence K. Allen, Asifa Mohamed Raffi, David A. Skaar, et al. “Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.” Pediatr Obes 16, no. 7 (July 2021): e12763. https://doi.org/10.1111/ijpo.12763.

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Ksinan, Albert J., Yaou Sheng, Elizabeth K. Do, Julia C. Schechter, Junfeng Jim Zhang, Rachel L. Maguire, Cathrine Hoyo, et al. “Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children.” Nicotine Tob Res 23, no. 7 (June 8, 2021): 1217–23. https://doi.org/10.1093/ntr/ntaa254.

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Fallavollita, Westley L., Elizabeth K. Do, Julia C. Schechter, Scott H. Kollins, Junfeng Jim Zheng, Jian Qin, Rachel L. Maguire, Cathrine Hoyo, Susan K. Murphy, and Bernard F. Fuemmeler. “Smoke-Free Home Rules and Association with Child Secondhand Smoke Exposure among Mother-Child Dyad Relationships.” Int J Environ Res Public Health 18, no. 10 (May 14, 2021). https://doi.org/10.3390/ijerph18105256.

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Fuemmeler, Bernard F., Mikhail G. Dozmorov, Elizabeth K. Do, Junfeng Jim Zhang, Carole Grenier, Zhiqing Huang, Rachel L. Maguire, Scott H. Kollins, Cathrine Hoyo, and Susan K. Murphy. “DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.” Environ Health Perspect 129, no. 5 (May 2021): 57010. https://doi.org/10.1289/EHP8099.

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Keyhan, Sanaz, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, et al. “Male obesity impacts DNA methylation reprogramming in sperm.” Clin Epigenetics 13, no. 1 (January 25, 2021): 17. https://doi.org/10.1186/s13148-020-00997-0.

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Murphy, Susan, Regina Whitaker, Gregory Sfakianos, Andrew Berchuck, and Zhiqing Huang. “Gene Expression using Affymetrix Human Genome U133 Plus 2 Arrays from 16 Primary and Recurrent Serous Epithelial Ovarian Cancers,” January 15, 2021. https://doi.org/10.7924/r43f4sx2k.

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Murphy, Susan, Gregory Sfakianos, Regina Whitaker, Andrew Berchuk, and Zhiqing Huang. “Primary and recurrent (second-look surgery) serous epithelial ovarian cancers Illumina Infinium HumanMethylation450 BeadChip data,” January 8, 2021. https://doi.org/10.7924/r4765hq57.

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Gu, Jeffrey, Julio Barrera, Young Yun, Susan K. Murphy, Thomas G. Beach, Randy L. Woltjer, Geidy E. Serrano, Boris Kantor, and Ornit Chiba-Falek. “Cell-Type Specific Changes in DNA Methylation of SNCA Intron 1 in Synucleinopathy Brains.” Front Neurosci 15 (2021): 652226. https://doi.org/10.3389/fnins.2021.652226.

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Visco, Zachary R., Gregory Sfakianos, Carole Grenier, Marie-Helene Boudreau, Sabrina Simpson, Isabel Rodriguez, Regina Whitaker, et al. “Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.” Front Oncol 11 (2021): 620873. https://doi.org/10.3389/fonc.2021.620873.

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Soubry, Adelheid, Susan K. Murphy, Greet Vansant, Yang He, Thomas M. Price, and Cathrine Hoyo. “Opposing Epigenetic Signatures in Human Sperm by Intake of Fast Food Versus Healthy Food.” Front Endocrinol (Lausanne) 12 (2021): 625204. https://doi.org/10.3389/fendo.2021.625204.

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