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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Acharya, Kelly S., Rose Schrott, Carole Grenier, Zhiqing Huang, Zade Holloway, Andrew Hawkey, Edward D. Levin, and Susan K. Murphy. “Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).” Sci Rep 10, no. 1 (July 23, 2020): 12251. https://doi.org/10.1038/s41598-020-69204-7.

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Fuemmeler, Bernard F., Yaou Sheng, Julia C. Schechter, Elizabeth Do, Nancy Zucker, Alesha Majors, Rachel Maguire, Susan K. Murphy, Cathrine Hoyo, and Scott H. Kollins. “Associations between attention deficit hyperactivity disorder symptoms and eating behaviors in early childhood.” Pediatr Obes 15, no. 7 (July 2020): e12631. https://doi.org/10.1111/ijpo.12631.

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York, Timothy P., Shawn J. Latendresse, Colleen Jackson-Cook, Dana M. Lapato, Sara Moyer, Aaron R. Wolen, Roxann Roberson-Nay, et al. “Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.” Epigenetics, May 24, 2020, 1–16. https://doi.org/10.1080/15592294.2020.1767277.

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Schechter, Julia, Elizabeth K. Do, Junfeng Jim Zhang, Cathrine Hoyo, Susan K. Murphy, Scott H. Kollins, and Bernard Fuemmeler. “Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms.” Nicotine Tob Res 22, no. 1 (January 27, 2020): 40–47. https://doi.org/10.1093/ntr/nty267.

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Yang, Wen-Hsuan, Zhiqing Huang, Jianli Wu, Chien-Kuang C. Ding, Susan K. Murphy, and Jen-Tsan Chi. “A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer.” Mol Cancer Res 18, no. 1 (January 2020): 79–90. https://doi.org/10.1158/1541-7786.MCR-19-0691.

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Schrott, Rose, Kelly Acharya, Nilda Itchon-Ramos, Andrew B. Hawkey, Erica Pippen, John T. Mitchell, Scott H. Kollins, Edward D. Levin, and Susan K. Murphy. “Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm.” Epigenetics 15, no. 1–2 (January 2020): 161–73. https://doi.org/10.1080/15592294.2019.1656158.

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York, T. P., S. J. Latendresse, C. Jackson-Cook, D. M. Lapato, S. Moyer, A. R. Wolen, R. Roberson-Nay, et al. “Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.” In Epigenetics, 2020. https://doi.org/10.1080/15592294.2020.1767277.

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Xue, Hong, Rachel L. Maguire, Jin Liu, Scott H. Kollins, Susan K. Murphy, Cathrine Hoyo, and Bernard F. Fuemmeler. “Snacking frequency and dietary intake in toddlers and preschool children.” Appetite 142 (November 1, 2019): 104369. https://doi.org/10.1016/j.appet.2019.104369.

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Yamanoi, Koji, Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Ryusuke Murakami, Mana Taki, et al. “Acquisition of a side population fraction augments malignant phenotype in ovarian cancer.” Sci Rep 9, no. 1 (October 2, 2019): 14215. https://doi.org/10.1038/s41598-019-50794-w.

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