Alick, Candice L., Rachel L. Maguire, Susan K. Murphy, Bernard F. Fuemmeler, Cathrine Hoyo, and John S. House. “Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.” Nutrients 13, no. 9 (September 13, 2021). https://doi.org/10.3390/nu13093180.
Susan Kay Murphy, PhD
My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease. I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.
Education and Training
- Ph.D., Wake Forest University, 1998
- B.A., University of North Carolina - Charlotte, 1992
Selected Grants and Awards
- Population Health Research Support IDIQ Base
- Duke Women's Reproductive Health Research Scholars
- Pharmacological Sciences Training Grant
- Duke University Program in Environmental Health
- Role of Age-Related Changes in the Tumor Microenvironment on Ovarian Cancer Progression
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?
- Translational Research in Surgical Oncology
- Building Interdisciplinary Research Careers in Women's Health
- Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort
- Social adversities, epigenetics, and the obesity epidemic
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate cancer
- Organization and Function of Cellular Structure
- Pharmacological Sciences Training Program
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity
- Epigenomics in insulin resistance associated overactive bladder
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease
- Duke University Program in Environmental Health
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES)
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES)
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer
- Immune regulated amino acid pathways in Alzheimer's Disease
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer
- Cancer Biology Training Grant
- Obesity and deregulation of imprinted genes in early life
- Epigenetic influence on the early childhood self-regulation capacities and obesity
- Ovarian Cancer Initiating Cells: Metabolic Characterization
- Gene Regulation in Recurrent Ovarian Cancers
- Disparities in cervical cancer precursors and deregulation of imprinted genes
- Nutrition, Deregulation of Imprinted Genes and Rapid Weight Gain in Early Life
- Characterizing Alcohol's Effects on Repair of Liver Injury
- Identification and Characterization of Epigenetically Labile Genes
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis
Holloway, Z., A. B. Hawkey, E. Pippen, H. White, V. Katragadda, B. Kenou, C. Wells, S. K. Murphy, A. H. Rezvani, and E. D. Levin. “Corrigendum to "Paternal cannabis extract exposure in rats: Preconception timing effects on neurobehavioral effects in offspring" [Neurotoxicology 81 (2020) 180-188].” Neurotoxicology, September 2, 2021. https://doi.org/10.1016/j.neuro.2021.08.009.
Monangi, Nagendra, Huan Xu, Rasheda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, Joan T. Price, et al. “Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis.” Bmj Glob Health 6, no. 9 (September 2021). https://doi.org/10.1136/bmjgh-2021-005856.
Maguire, Rachel L., John S. House, Dillon T. Lloyd, Harlyn G. Skinner, Terrence K. Allen, Asifa Mohamed Raffi, David A. Skaar, et al. “Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.” Pediatr Obes 16, no. 7 (July 2021): e12763. https://doi.org/10.1111/ijpo.12763.
Crute, Christine E., Samantha Hall, Chelsea Landon, Angela Garner, Susan K. Murphy, and Liping Feng. “Maternal Exposure to an Environmentally Relevant Mixture of Per- and Polyfluoroalkyl Substances (PFAS) Leads to Adverse Pregnancy Outcomes in a New Zealand White Rabbit Model.” In Reproductive Sciences, 28:255A-255A, 2021.
Bosire, Claire, Adriana C. Vidal, Jennifer S. Smith, Dereje Jima, Zhiqing Huang, David Skaar, Fidel Valea, et al. “Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia.” Infect Agent Cancer 16, no. 1 (June 13, 2021): 42. https://doi.org/10.1186/s13027-021-00382-3.
Ksinan, Albert J., Yaou Sheng, Elizabeth K. Do, Julia C. Schechter, Junfeng Jim Zhang, Rachel L. Maguire, Cathrine Hoyo, et al. “Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children.” Nicotine Tob Res 23, no. 7 (June 8, 2021): 1217–23. https://doi.org/10.1093/ntr/ntaa254.
Fallavollita, Westley L., Elizabeth K. Do, Julia C. Schechter, Scott H. Kollins, Junfeng Jim Zheng, Jian Qin, Rachel L. Maguire, Cathrine Hoyo, Susan K. Murphy, and Bernard F. Fuemmeler. “Smoke-Free Home Rules and Association with Child Secondhand Smoke Exposure among Mother-Child Dyad Relationships.” Int J Environ Res Public Health 18, no. 10 (May 14, 2021). https://doi.org/10.3390/ijerph18105256.
Fuemmeler, Bernard F., Mikhail G. Dozmorov, Elizabeth K. Do, Junfeng Jim Zhang, Carole Grenier, Zhiqing Huang, Rachel L. Maguire, Scott H. Kollins, Cathrine Hoyo, and Susan K. Murphy. “DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.” Environ Health Perspect 129, no. 5 (May 2021): 57010. https://doi.org/10.1289/EHP8099.