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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140; Duke PO Box 90534, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Alick, Candice L., Rachel L. Maguire, Susan K. Murphy, Bernard F. Fuemmeler, Cathrine Hoyo, and John S. House. “Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.” Nutrients 13, no. 9 (September 13, 2021). https://doi.org/10.3390/nu13093180.

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Holloway, Z., A. B. Hawkey, E. Pippen, H. White, V. Katragadda, B. Kenou, C. Wells, S. K. Murphy, A. H. Rezvani, and E. D. Levin. “Corrigendum to "Paternal cannabis extract exposure in rats: Preconception timing effects on neurobehavioral effects in offspring" [Neurotoxicology 81 (2020) 180-188].” Neurotoxicology, September 2, 2021. https://doi.org/10.1016/j.neuro.2021.08.009.

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Monangi, Nagendra, Huan Xu, Rasheda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, Joan T. Price, et al. “Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis.” Bmj Glob Health 6, no. 9 (September 2021). https://doi.org/10.1136/bmjgh-2021-005856.

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Maguire, Rachel L., John S. House, Dillon T. Lloyd, Harlyn G. Skinner, Terrence K. Allen, Asifa Mohamed Raffi, David A. Skaar, et al. “Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort.” Pediatr Obes 16, no. 7 (July 2021): e12763. https://doi.org/10.1111/ijpo.12763.

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Crute, Christine E., Samantha Hall, Chelsea Landon, Angela Garner, Susan K. Murphy, and Liping Feng. “Maternal Exposure to an Environmentally Relevant Mixture of Per- and Polyfluoroalkyl Substances (PFAS) Leads to Adverse Pregnancy Outcomes in a New Zealand White Rabbit Model.” In Reproductive Sciences, 28:255A-255A, 2021.

Scholars@Duke

Bosire, Claire, Adriana C. Vidal, Jennifer S. Smith, Dereje Jima, Zhiqing Huang, David Skaar, Fidel Valea, et al. “Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia.” Infect Agent Cancer 16, no. 1 (June 13, 2021): 42. https://doi.org/10.1186/s13027-021-00382-3.

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Ksinan, Albert J., Yaou Sheng, Elizabeth K. Do, Julia C. Schechter, Junfeng Jim Zhang, Rachel L. Maguire, Cathrine Hoyo, et al. “Identifying the Best Questions for Rapid Screening of Secondhand Smoke Exposure Among Children.” Nicotine Tob Res 23, no. 7 (June 8, 2021): 1217–23. https://doi.org/10.1093/ntr/ntaa254.

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Fallavollita, Westley L., Elizabeth K. Do, Julia C. Schechter, Scott H. Kollins, Junfeng Jim Zheng, Jian Qin, Rachel L. Maguire, Cathrine Hoyo, Susan K. Murphy, and Bernard F. Fuemmeler. “Smoke-Free Home Rules and Association with Child Secondhand Smoke Exposure among Mother-Child Dyad Relationships.” Int J Environ Res Public Health 18, no. 10 (May 14, 2021). https://doi.org/10.3390/ijerph18105256.

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Fuemmeler, Bernard F., Mikhail G. Dozmorov, Elizabeth K. Do, Junfeng Jim Zhang, Carole Grenier, Zhiqing Huang, Rachel L. Maguire, Scott H. Kollins, Cathrine Hoyo, and Susan K. Murphy. “DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.” Environ Health Perspect 129, no. 5 (May 2021): 57010. https://doi.org/10.1289/EHP8099.

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Keyhan, Sanaz, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, et al. “Male obesity impacts DNA methylation reprogramming in sperm.” Clinical Epigenetics 13, no. 1 (January 25, 2021): 17. https://doi.org/10.1186/s13148-020-00997-0.

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