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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140; Duke PO Box 90534, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Acharya, K. S., R. Schrott, C. Grenier, Z. Huang, Z. Holloway, A. Hawkey, E. D. Levin, and S. K. Murphy. “Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).” In Scientific Reports, Vol. 10, 2020. https://doi.org/10.1038/s41598-020-69204-7.

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Ksinan, Albert J., Yaou Sheng, Elizabeth K. Do, Julia C. Schechter, Junfeng Jim Zhang, Rachel L. Maguire, Cathrine Hoyo, et al. “Identifying the best questions for rapid screening of secondhand smoke exposure among children.” Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, November 29, 2020. https://doi.org/10.1093/ntr/ntaa254.

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Neumann, Alexander, Esther Walton, Silvia Alemany, Charlotte Cecil, Juan Ramon González, Dereje D. Jima, Jari Lahti, et al. “Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.” Transl Psychiatry 10, no. 1 (November 12, 2020): 398. https://doi.org/10.1038/s41398-020-01058-z.

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York, Timothy P., Shawn J. Latendresse, Colleen Jackson-Cook, Dana M. Lapato, Sara Moyer, Aaron R. Wolen, Roxann Roberson-Nay, et al. “Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.” Epigenetics 15, no. 11 (November 2020): 1243–58. https://doi.org/10.1080/15592294.2020.1767277.

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Holloway, Zade R., Andrew B. Hawkey, Alexandra K. Torres, Janequia Evans, Erica Pippen, Hannah White, Vaishnavi Katragadda, et al. “Paternal cannabis extract exposure in rats: Preconception timing effects on neurodevelopmental behavior in offspring.” Neurotoxicology 81 (October 19, 2020): 180–88. https://doi.org/10.1016/j.neuro.2020.10.007.

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Huang, Zhiqing, Eiji Kondoh, Zachary R. Visco, Tsukasa Baba, Noriomi Matsumura, Emma Dolan, Regina S. Whitaker, et al. “Targeting dormant ovarian cancer cells in vitro and in an in vivo mouse model of platinum resistance.” Molecular Cancer Therapeutics, October 9, 2020. https://doi.org/10.1158/1535-7163.mct-20-0119.

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Schrott, Rose, Maya Rajavel, Kelly Acharya, Zhiqing Huang, Chaitanya Acharya, Andrew Hawkey, Erica Pippen, H Kim Lyerly, Edward D. Levin, and Susan K. Murphy. “Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin.” Sci Rep 10, no. 1 (September 29, 2020): 16022. https://doi.org/10.1038/s41598-020-72783-0.

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Acharya, Kelly S., Rose Schrott, Carole Grenier, Zhiqing Huang, Zade Holloway, Andrew Hawkey, Edward D. Levin, and Susan K. Murphy. “Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).” Sci Rep 10, no. 1 (July 23, 2020): 12251. https://doi.org/10.1038/s41598-020-69204-7.

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Fuemmeler, Bernard F., Yaou Sheng, Julia C. Schechter, Elizabeth Do, Nancy Zucker, Alesha Majors, Rachel Maguire, Susan K. Murphy, Cathrine Hoyo, and Scott H. Kollins. “Associations between attention deficit hyperactivity disorder symptoms and eating behaviors in early childhood.” Pediatr Obes 15, no. 7 (July 2020): e12631. https://doi.org/10.1111/ijpo.12631.

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Schechter, Julia, Elizabeth K. Do, Junfeng Jim Zhang, Cathrine Hoyo, Susan K. Murphy, Scott H. Kollins, and Bernard Fuemmeler. “Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms.” Nicotine Tob Res 22, no. 1 (January 27, 2020): 40–47. https://doi.org/10.1093/ntr/nty267.

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