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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Sorrow, P, Maguire, R, Murphy, SK, Belcher, SM, and Hoyo, C. "Elevated metabolites of acetaminophen in cord blood of children with obesity.(Accepted)" Pediatric Obesity 14, no. 1 (January 2019).

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Reese, SE, Xu, C-J, den Dekker, HT, Lee, MK, Sikdar, S, Ruiz-Arenas, C, Merid, SK, Rezwan, FI, Page, CM, Ullemar, V, Melton, PE, Oh, SS, Yang, IV, Burrows, K, Söderhäll, C, Jima, DD, Gao, L, Arathimos, R, Küpers, LK, Wielscher, M, Rzehak, P, Lahti, J, Laprise, C, Madore, A-M, Ward, J, Bennett, BD, Wang, T, Bell, DA, BIOS Consortium, , Vonk, JM, Håberg, SE, Zhao, S, Karlsson, R, Hollams, E, Hu, D, Richards, AJ, Bergström, A, Sharp, GC, Felix, JF, Bustamante, M, Gruzieva, O, Maguire, RL, Gilliland, F, Baïz, N, Nohr, EA, Corpeleijn, E, Sebert, S, Karmaus, W, Grote, V, Kajantie, E, Magnus, MC, Örtqvist, AK, Eng, C, Liu, AH, Kull, I, Jaddoe, VWV, Sunyer, J, Kere, J, Hoyo, C, Annesi-Maesano, I, Arshad, SH, Koletzko, B, Brunekreef, B, Binder, EB, Räikkönen, K, Reischl, E, Holloway, JW, Jarvelin, M-R, Snieder, H, Kazmi, N, Breton, CV, Murphy, SK, Pershagen, G, Anto, JM, Relton, CL, Schwartz, DA, Burchard, EG, Huang, R-C, Nystad, W, Almqvist, C, Henderson, AJ, Melén, E, Duijts, L, Koppelman, GH, and London, SJ. "Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma." The Journal of Allergy and Clinical Immunology (December 20, 2018).

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Murphy, SK, Itchon-Ramos, N, Visco, Z, Huang, Z, Grenier, C, Schrott, R, Acharya, K, Boudreau, M-H, Price, TM, Raburn, DJ, Corcoran, DL, Lucas, JE, Mitchell, JT, McClernon, FJ, Cauley, M, Hall, BJ, Levin, ED, and Kollins, SH. "Cannabinoid exposure and altered DNA methylation in rat and human sperm." Epigenetics (December 6, 2018).

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Kantor, B, Tagliafierro, L, Gu, J, Zamora, ME, Ilich, E, Grenier, C, Huang, ZY, Murphy, S, and Chiba-Falek, O. "Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD." Molecular Therapy : the Journal of the American Society of Gene Therapy 26, no. 11 (November 2018): 2638-2649.

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Moylan, CA, Sorrow, PA, Mavis, A, Bashir, M, Jima, D, Maguire, R, Bozdogan, E, Buie, S, Murphy, SK, Diehl, AM, Hoyo, C, and Abdelmalek, MF. "Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018.

Scholars@Duke

Moylan, CA, Sorrow, PA, Mavis, A, Bashir, M, Jima, D, Maguire, R, Bozdogan, E, Buie, S, Murphy, SK, Diehl, AM, Hoyo, C, and Abdelmalek, MF. "Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018.

Scholars@Duke

Do, EK, Zucker, NL, Huang, ZY, Schechter, JC, Kollins, SH, Maguire, RL, Murphy, SK, Hoyo, C, and Fuemmeler, BF. "Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children." Pediatric Obesity (September 19, 2018).

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Gomih, A, Smith, JS, North, KE, Hudgens, MG, Brewster, WR, Huang, Z, Skaar, D, Valea, F, Bentley, RC, Vidal, AC, Maguire, RL, Jirtle, RL, Murphy, SK, and Hoyo, C. "DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions." International Journal of Cancer 143, no. 3 (August 2018): 552-560.

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Gao, L, Liu, X, Millstein, J, Siegmund, KD, Dubeau, L, Maguire, RL, Jim Zhang, J, Fuemmeler, BF, Kollins, SH, Hoyo, C, Murphy, SK, and Breton, CV. "Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes." Clinical Epigenetics 10, no. 1 (July 20, 2018): 98-null.

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Green, AJ, Hoyo, C, Mattingly, CJ, Luo, Y, Tzeng, J-Y, Murphy, SK, Buchwalter, DB, and Planchart, A. "Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study." International Journal of Obesity (2005) 42, no. 7 (July 2018): 1285-1295.

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