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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Gonzalez-Nahm, S, Mendez, MA, Benjamin-Neelon, SE, Murphy, SK, Hogan, VK, Rowley, DL, and Hoyo, C. "DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years." Clinical Epigenetics 10 (January 2018): 90-null.

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Chawla, D, Fuemmeler, B, Benjamin-Neelon, SE, Hoyo, C, Murphy, S, and Daniels, JL. "Early prenatal vitamin D concentrations and social-emotional development in infants." The Journal of Maternal Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (December 4, 2017): 1-8.

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Li, X, Moylan, CA, Baker, SS, Liu, W, Baker, RD, Murphy, SK, Abdelmalek, MF, Zhu, R, Diehl, AM, and Zhu, L. "Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis." October 2017.

Scholars@Duke

Sharp, GC, Salas, LA, Monnereau, C, Allard, C, Yousefi, P, Everson, TM, Bohlin, J, Xu, Z, Huang, R-C, Reese, SE, Xu, C-J, Baïz, N, Hoyo, C, Agha, G, Roy, R, Holloway, JW, Ghantous, A, Merid, SK, Bakulski, KM, Küpers, LK, Zhang, H, Richmond, RC, Page, CM, Duijts, L, Lie, RT, Melton, PE, Vonk, JM, Nohr, EA, Williams-DeVane, C, Huen, K, Rifas-Shiman, SL, Ruiz-Arenas, C, Gonseth, S, Rezwan, FI, Herceg, Z, Ekström, S, Croen, L, Falahi, F, Perron, P, Karagas, MR, Quraishi, BM, Suderman, M, Magnus, MC, Jaddoe, VWV, Taylor, JA, Anderson, D, Zhao, S, Smit, HA, Josey, MJ, Bradman, A, Baccarelli, AA, Bustamante, M, Håberg, SE, Pershagen, G, Hertz-Picciotto, I, Newschaffer, C, Corpeleijn, E, Bouchard, L, Lawlor, DA, Maguire, RL, Barcellos, LF, Davey Smith, G, Eskenazi, B, Karmaus, W, Marsit, CJ, Hivert, M-F, Snieder, H, Fallin, MD, Melén, E, Munthe-Kaas, MC, Arshad, H, Wiemels, JL, Annesi-Maesano, I, Vrijheid, M, Oken, E, Holland, N, Murphy, SK, Sørensen, TIA, Koppelman, GH, Newnham, JP, Wilcox, AJ, Nystad, W, London, SJ, Felix, JF, and Relton, CL. "Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium." Human Molecular Genetics 26, no. 20 (October 2017): 4067-4085.

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Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017.

Scholars@Duke

Murphy, SK, Schrott, R, Visco, Z, Huang, Z, Grenier, C, Mitchell, J, Schechter, J, Lucas, J, Levin, ED, Price, T, and Kollins, SH. "Environment and Gametic Epigenetic Reprogramming." September 2017.

Scholars@Duke

Cordero, FJ, Huang, Z, Grenier, C, He, X, Hu, G, McLendon, RE, Murphy, SK, Hashizume, R, and Becher, OJ. "Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG." Molecular Cancer Research : Mcr 15, no. 9 (September 2017): 1243-1254.

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Liu, Y, Reynolds, LM, Ding, J, Hou, L, Lohman, K, Young, T, Cui, W, Huang, Z, Grenier, C, Wan, M, Stunnenberg, HG, Siscovick, D, Hou, L, Psaty, BM, Rich, SS, Rotter, JI, Kaufman, JD, Burke, GL, Murphy, S, Jacobs, DR, Post, W, Hoeschele, I, Bell, DA, Herrington, D, Parks, JS, Tracy, RP, McCall, CE, and Stein, JH. "Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis." Nature communications 8, no. 1 (August 30, 2017): 393-.

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McCullough, LE, Miller, EE, Calderwood, LE, Shivappa, N, Steck, SE, Forman, MR, A Mendez, M, Maguire, R, Fuemmeler, BF, Kollins, SH, D Bilbo, S, Huang, Z, Murtha, AP, Murphy, SK, Hébert, JR, and Hoyo, C. "Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?." Epigenetics 12, no. 8 (August 2017): 688-697.

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Gonzalez-Nahm, S, Mendez, M, Robinson, W, Murphy, SK, Hoyo, C, Hogan, V, and Rowley, D. "Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants." Environmental epigenetics 3, no. 2 (May 6, 2017): dvx007-.

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