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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Hawkey, Andrew B., Hannah White, Erica Pippen, Eva Greengrove, Amir H. Rezvani, Susan K. Murphy, and Edward D. Levin. “Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.” Neurotoxicol Teratol 74 (July 2019): 106808. https://doi.org/10.1016/j.ntt.2019.05.001.

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Levin, Edward D., Andrew B. Hawkey, Brandon J. Hall, Marty Cauley, Susan Slade, Elisa Yazdani, Bruny Kenou, et al. “Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.” Neurotoxicology and Teratology 74 (July 2019): 106806. https://doi.org/10.1016/j.ntt.2019.04.003.

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Maddala, Rupalatha, Susan K. Murphy, and Vasanth Rao. “S100A4 deficiency-induced aberrant gene expression during lens differentiation is epigenetically regulated through altered Histone 3 lysine methylation marking.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.

Scholars@Duke

Reese, Sarah E., Cheng-Jian Xu, Herman T. den Dekker, Mi Kyeong Lee, Sinjini Sikdar, Carlos Ruiz-Arenas, Simon K. Merid, et al. “Epigenome-wide meta-analysis of DNA methylation and childhood asthma.” J Allergy Clin Immunol 143, no. 6 (June 2019): 2062–74. https://doi.org/10.1016/j.jaci.2018.11.043.

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Meekins, A Rebecca, Susan K. Murphy, Carole Grenier, Zhiqing Huang, Megan S. Bradley, Cindy L. Amundsen, Jennifer Wu, and Nazema Y. Siddiqui. “Role of β-3 adrenergic receptor polymorphism in overactive bladder.” Neurourol Urodyn 38, no. 5 (June 2019): 1261–65. https://doi.org/10.1002/nau.24006.

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Moylan, Cynthia A., Carole Grenier, Jeongeun Hyun, Kuo Du, Ricardo Henao, Manal F. Abdelmalek, Susan K. Murphy, and Anna Mae Diehl. “DYSREGULATED DNA METHYLATION OF FGFR2, CASP1, AND BCAT1 ASSOCIATES WITH NONALCOHOLIC FATTY LIVER DISEASE SEVERITY AND CAN BE IDENTIFIED IN PERIPHERAL BLOOD.” In Gastroenterology, 156:S1360–61. W B SAUNDERS CO-ELSEVIER INC, 2019.

Scholars@Duke

Chawla, Devika, Bernard Fuemmeler, Sara E. Benjamin-Neelon, Cathrine Hoyo, Susan Murphy, and Julie L. Daniels. “Early prenatal vitamin D concentrations and social-emotional development in infants.” J Matern Fetal Neonatal Med 32, no. 9 (May 2019): 1441–48. https://doi.org/10.1080/14767058.2017.1408065.

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Küpers, Leanne K., Claire Monnereau, Gemma C. Sharp, Paul Yousefi, Lucas A. Salas, Akram Ghantous, Christian M. Page, et al. “Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.” Nat Commun 10, no. 1 (April 23, 2019): 1893. https://doi.org/10.1038/s41467-019-09671-3.

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Martin, Chantel L., Dereje Jima, Gemma C. Sharp, Lauren E. McCullough, Sarah S. Park, Kymberly M. Gowdy, David Skaar, et al. “Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study.” Epigenetics 14, no. 4 (April 2019): 325–40. https://doi.org/10.1080/15592294.2019.1581594.

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Tagliafierro, Lidia, Ekaterina Ilich, Malik Moncalvo, Jeffrey Gu, Ahila Sriskanda, Carole Grenier, Susan K. Murphy, Ornit Chiba-Falek, and Boris Kantor. “Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.” J Vis Exp, no. 145 (March 29, 2019). https://doi.org/10.3791/59241.

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