Moylan, Cynthia A., Carole Grenier, Jeongeun Hyun, Kuo Du, Ricardo Henao, Manal F. Abdelmalek, Susan K. Murphy, and Anna Mae Diehl. “DYSREGULATED DNA METHYLATION OF FGFR2, CASP1, AND BCAT1 ASSOCIATES WITH NONALCOHOLIC FATTY LIVER DISEASE SEVERITY AND CAN BE IDENTIFIED IN PERIPHERAL BLOOD.” In Gastroenterology, 156:S1360–61. W B SAUNDERS CO-ELSEVIER INC, 2019.
Susan Kay Murphy, PhD
Associate Professor in Obstetrics and Gynecology
Campus Mail:
119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone:
(919) 681-3423
Email:
susan.murphy@duke.edu
Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.
Education and Training
- Ph.D., Wake Forest University, 1998
- B.A., University of North Carolina at Charlotte, 1992
Research
Selected Grants and Awards
- Population Health Research Support IDIQ Base
- Duke University Program in Environmental Health
- Duke KURe Program
- Duke KURe Program
- Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?
- Building Interdisciplinary Research Careers in Women's Health
- Building Interdisciplinary Research Careers in Women's Health
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight
- Translational Research in Surgical Oncology
- Translational Research in Surgical Oncology
- Duke University Medical Center (DUMC) Pelvic Floor Disorders Network (PFDN) Clinical Site
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Organization and Function of Cellular Structure
- Organization and Function of Cellular Structure
- Pharmacological Sciences Training Program
- Epigenomics in insulin resistance associated overactive bladder
- Clarifying the role of tobacco retail outlets on maternal smoking during pregnancy and child secondhand smoke exposure
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease
- Duke University Program in Environmental Health
- Social adversities, epigenetics, and the obesity epidemic
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES)
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES)
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer
- Immune regulated amino acid pathways in Alzheimer's Disease
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer
- Cancer Biology Training Grant
- Obesity and deregulation of imprinted genes in early life
- Epigenetic influence on early childhood self-regulation capacities and obesity
- Ovarian Cancer Initiating Cells: Metabolic Characterization
- Gene Regulation in Recurrent Ovarian Cancers
- Disparities in cervical cancer precursors and deregulation of imprinted genes
- Nutrition, Deregulation of Imprinted Genes
- Characterizing Alcohol's Effects on Repair of Liver Injury
- Identification and Characterization of Epigenetically Labile Genes
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis
Publications
Chawla, Devika, Bernard Fuemmeler, Sara E. Benjamin-Neelon, Cathrine Hoyo, Susan Murphy, and Julie L. Daniels. “Early prenatal vitamin D concentrations and social-emotional development in infants..” J Matern Fetal Neonatal Med 32, no. 9 (May 2019): 1441–48. https://doi.org/10.1080/14767058.2017.1408065.
Küpers, Leanne K., Claire Monnereau, Gemma C. Sharp, Paul Yousefi, Lucas A. Salas, Akram Ghantous, Christian M. Page, et al. “Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight..” Nat Commun 10, no. 1 (April 23, 2019). https://doi.org/10.1038/s41467-019-09671-3.
Martin, Chantel L., Dereje Jima, Gemma C. Sharp, Lauren E. McCullough, Sarah S. Park, Kymberly M. Gowdy, David Skaar, et al. “Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study..” Epigenetics 14, no. 4 (April 2019): 325–40. https://doi.org/10.1080/15592294.2019.1581594.
Tagliafierro, Lidia, Ekaterina Ilich, Malik Moncalvo, Jeffrey Gu, Ahila Sriskanda, Carole Grenier, Susan K. Murphy, Ornit Chiba-Falek, and Boris Kantor. “Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models..” J Vis Exp, no. 145 (March 29, 2019). https://doi.org/10.3791/59241.
Acharya, Kelly S., Rose Schrott, Edward Levin, and Susan K. Murphy. “Epigenetic Alterations in Cytochrome P450 Oxidoreductase (Por) in Sperm Exposed to Tetrahydrocannabinol (THC)..” In Reproductive Sciences, 26:92A-92A. SAGE PUBLICATIONS INC, 2019.
Fuemmeler, Bernard F., Nancy Zucker, Yaou Sheng, Carmen E. Sanchez, Rachel Maguire, Susan K. Murphy, Scott H. Kollins, and Cathrine Hoyo. “Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children..” Int J Environ Res Public Health 16, no. 4 (February 25, 2019). https://doi.org/10.3390/ijerph16040667.
Do, E. K., N. L. Zucker, Z. Y. Huang, J. C. Schechter, S. H. Kollins, R. L. Maguire, S. K. Murphy, C. Hoyo, and B. F. Fuemmeler. “Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children..” Pediatr Obes 14, no. 2 (February 2019). https://doi.org/10.1111/ijpo.12454.
Sorrow, P., R. Maguire, S. K. Murphy, S. M. Belcher, and C. Hoyo. “Elevated metabolites of acetaminophen in cord blood of children with obesity..” Pediatr Obes 14, no. 1 (January 2019). https://doi.org/10.1111/ijpo.12465.
Schechter, Julia, Elizabeth K. Do, Junfeng Jim Zhang, Cathrine Hoyo, Susan K. Murphy, Scott H. Kollins, and Bernard Fuemmeler. “Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms..” Nicotine Tob Res, December 24, 2018. https://doi.org/10.1093/ntr/nty267.