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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Nagura, Michikazu, Noriomi Matsumura, Tsukasa Baba, Ryusuke Murakami, Budiman Kharma, Junzo Hamanishi, Ken Yamaguchi, et al. “Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta..” Gynecol Oncol 136, no. 1 (January 2015): 104–11. https://doi.org/10.1016/j.ygyno.2014.11.075.

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Soubry, A., S. K. Murphy, F. Wang, Z. Huang, A. C. Vidal, B. F. Fuemmeler, J. Kurtzberg, et al. “Newborns of obese parents have altered DNA methylation patterns at imprinted genes.” International Journal of Obesity 39, no. 4 (January 1, 2015): 650–57. https://doi.org/10.1038/ijo.2013.193.

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Ding, Jingzhong, Lindsay M. Reynolds, Tanja Zeller, Christian Muller, Kurt Lohman, Zhiqing Huang, Alberto de la Fuente, et al. “Alterations of a Cellular Cholesterol Metabolism Network is a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.

Scholars@Duke

Kharma, Budiman, Tsukasa Baba, Noriomi Matsumura, Hyun Sook Kang, Junzo Hamanishi, Ryusuke Murakami, Melissa M. McConechy, et al. “STAT1 drives tumor progression in serous papillary endometrial cancer..” Cancer Res 74, no. 22 (November 15, 2014): 6519–30. https://doi.org/10.1158/0008-5472.CAN-14-0847.

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Nye, Monica D., Cathrine Hoyo, Frances Wang, Amy P. Murtha, Joellen M. Schildkraut, Joanne Kurtzberg, Randy L. Jirtle, Zhiqing Huang, and Susan K. Murphy. “Abstract B22: Altered methylation profiles of imprinted genes in response to prenatal exposure to cigarette smoke in the Newborn Epigenetic STudy (NEST) cohort.” Epidemiology, Lifestyle, and Genetics, November 2014. https://doi.org/10.1158/1538-7755.disp13-b22.

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Stevens, Ellen V., Regina Whitaker, Audrey Guinet, Ching-Yi Chang, Carole Grenier, Jeffrey Marks, Donald P. McDonnell, Susan K. Murphy, Andrew Berchuck, and Stephanie Gaillard. “Abstract 4570: Role of ERRalpha in ovarian cancer.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4570.

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Kharma, Budiman, Tsukasa Baba, Noriomi Matsumura, Hyun Sook Kang, Ryusuke Murakami, Ken Yamaguchi, Junzo Hamanishi, Masaki Mandai, Susan K. Murphy, and Ikuo Konishi. “Abstract LB-123: Novel function of STAT1 pathway as a modulator of tumor progression in serous papillary endometrial cancer.” In Molecular and Cellular Biology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-lb-123.

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Yamaguchi, Ken, Zhiqing Huang, Noriomi Matsumura, Masaki Mandai, Takako Okamoto, Tsukasa Baba, Ikuo Konishi, Andrew Berchuck, and Susan K. Murphy. “Epigenetic determinants of ovarian clear cell carcinoma biology..” Int J Cancer 135, no. 3 (August 1, 2014): 585–97. https://doi.org/10.1002/ijc.28701.

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Hoyo, Cathrine, Anne Kjersti Daltveit, Edwin Iversen, Sara E. Benjamin-Neelon, Bernard Fuemmeler, Joellen Schildkraut, Amy P. Murtha, et al. “Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort..” Epigenetics 9, no. 8 (August 2014): 1120–30. https://doi.org/10.4161/epi.29332.

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Vidal, Adriana C., Jennifer S. Smith, Fidel Valea, Rex Bentley, Maggie Gradison, Kimberly S. H. Yarnall, Anne Ford, et al. “HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA..” Cancer Causes Control 25, no. 8 (August 2014): 1055–62. https://doi.org/10.1007/s10552-014-0406-2.

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