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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Liu, Y, Hoyo, C, Murphy, S, Huang, Z, Overcash, F, Thompson, J, Brown, H, and Murtha, AP. "DNA methylation at imprint regulatory regions in preterm birth and infection." American Journal of Obstetrics and Gynecology 208, no. 5 (2013): 395.e1-395.e7.

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Huang, Z, and Murphy, SK. "Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma. (Published online)" Front Oncol 3 (2013): 131-.

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Murphy, SK, Bassil, CF, and Huang, Z. "Main principles and outcomes of DNA methylation analysis." Methods Mol Biol 1049 (2013): 67-74.

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Vidal, AC, Murtha, AP, Murphy, SK, Fortner, K, Overcash, F, Henry, N, Schildkraut, JM, Forman, MR, Demark-Wahnefried, W, Kurtzberg, J, Jirtle, R, and Hoyo, C. "Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants." Int J Pediatr 2013 (2013): 191472-.

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Huang, Z, Bassil, CF, and Murphy, SK. "Methylation-specific PCR." Methods Mol Biol 1049 (2013): 75-82.

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Murphy, SK. "Prenatal sensitization of a postnatal trigger for metabolic disease." Journal of Clinical Investigation 123, no. 7 (2013): 2786-2788.

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Alvarez Secord, A, Bernardini, MQ, Broadwater, G, Grace, LA, Huang, Z, Baba, T, Kondoh, E, Sfakianos, G, Havrilesky, LJ, and Murphy, SK. "TP53 Status is Associated with Thrombospondin1 Expression In vitro. (Published online)" Front Oncol 3 (2013): 269-.

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Kharma, B, Baba, T, Mandai, M, Matsumura, N, Murphy, SK, Kang, HS, Yamanoi, K, Hamanishi, J, Yamaguchi, K, Yoshioka, Y, and al, E. "Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers." International Journal of Cancer (2013).

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Kharma, B, Baba, T, Mandai, M, Matsumura, N, Murphy, SK, Kang, HS, Yamanoi, K, Hamanishi, J, Yamaguchi, K, Yoshioka, Y, and Konishi, I. "Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers." International Journal of Cancer 133, no. 9 (2013): 2234-2244.

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Sfakianos, GP, Iversen, ES, Whitaker, R, Akushevich, L, Schildkraut, JM, Murphy, SK, Marks, JR, and Berchuck, A. "Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues." Gynecologic Oncology 129, no. 1 (2013): 159-164.

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