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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Kharma, B, Baba, T, Mandai, M, Matsumura, N, Murphy, SK, Kang, HS, Yamanoi, K, Hamanishi, J, Yamaguchi, K, Yoshioka, Y, and Konishi, I. "Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers." International Journal of Cancer 133, no. 9 (2013): 2234-2244.

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Kharma, B, Baba, T, Mandai, M, Matsumura, N, Murphy, SK, Kang, HS, Yamanoi, K, Hamanishi, J, Yamaguchi, K, Yoshioka, Y, and al, E. "Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers." International Journal of Cancer (2013).

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Sfakianos, GP, Iversen, ES, Whitaker, R, Akushevich, L, Schildkraut, JM, Murphy, SK, Marks, JR, and Berchuck, A. "Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues." Gynecologic Oncology 129, no. 1 (2013): 159-164.

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Joubert, BR, Håberg, SE, Nilsen, RM, Wang, X, Vollset, SE, Murphy, SK, Huang, Z, Hoyo, C, Midttun, Ø, Cupul-Uicab, LA, Ueland, PM, Wu, MC, Nystad, W, Bell, DA, Peddada, SD, and London, SJ. "450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy." Environmental Health Perspectives 120, no. 10 (October 2012): 1425-1431.

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Korch, C, Spillman, MA, Jackson, TA, Jacobsen, BM, Murphy, SK, Lessey, BA, Jordan, VC, and Bradford, AP. "DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination." Gynecologic Oncology 127, no. 1 (October 2012): 241-248.

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Garrett, ME, Moylan, CA, Gibson, J, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Abdelmalek, MF, Murphy, SK, Diehl, AM, Hauser, M, and Ashley-Koch, AE. "Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease." October 2012.

Scholars@Duke

Das, R, Anderson, N, Koran, MI, Weidman, JR, Mikkelsen, TS, Kamal, M, Murphy, SK, Linblad-Toh, K, Greally, JM, and Jirtle, RL. "Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. (Published online)" BMC Genomics 13 (August 16, 2012): 394-.

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Liu, Y, Murphy, SK, Murtha, AP, Fuemmeler, BF, Schildkraut, J, Huang, Z, Overcash, F, Kurtzberg, J, Jirtle, R, Iversen, ES, Forman, MR, and Hoyo, C. "Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements." Epigenetics 7, no. 7 (July 2012): 735-746.

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Perkins, E, Murphy, SK, Murtha, AP, Schildkraut, J, Jirtle, RL, Demark-Wahnefried, W, Forman, MR, Kurtzberg, J, Overcash, F, Huang, Z, and Hoyo, C. "Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children." The Journal of Pediatrics 161, no. 1 (July 2012): 31-39.

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Moylan, CA, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Ashley-Koch, AE, Garrett, ME, Abdelmalek, MF, Hauser, MA, Murphy, SK, and Diehl, AM. "Epigenetic Regulation of Gene Expression in NAFLD." May 2012.

Scholars@Duke

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