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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Huang, Z, Lowery, WJ, Berchuck, A, and Murphy, SK. "Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation." Cancer Research 72, no. 8 Supplement (April 15, 2012): 5363-5363.

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Okamoto, T, Yamaguchi, K, Huang, Z, Whitaker, R, Konishi, I, Berchuck, A, and Murphy, SK. "Abstract LB-87: Methylated-mediated repression of ZNF154 in ovarian cancer is associated with poor overall survival." Cancer Research 72, no. 8 Supplement (April 15, 2012): LB-87-LB-87.

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Hoyo, C, Fortner, K, Murtha, AP, Schildkraut, JM, Soubry, A, Demark-Wahnefried, W, Jirtle, RL, Kurtzberg, J, Forman, MR, Overcash, F, Huang, Z, and Murphy, SK. "Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight." Cancer Causes Control 23, no. 4 (April 2012): 635-645.

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Murphy, SK, Adigun, A, Huang, Z, Overcash, F, Wang, F, Jirtle, RL, Schildkraut, JM, Murtha, AP, Iversen, ES, and Hoyo, C. "Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke." Gene 494, no. 1 (February 15, 2012): 36-43.

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Murphy, SK. "Targeting the epigenome in ovarian cancer." Future Oncol 8, no. 2 (February 2012): 151-164. (Review)

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Murphy, SK, Huang, Z, and Hoyo, C. "Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues." PLoS One 7, no. 7 (2012): e40924-.

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Hoyo, C, Murphy, SK, Schildkraut, JM, Vidal, AC, Skaar, D, Millikan, RC, Galanko, J, Sandler, RS, Jirtle, R, and Keku, T. "IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites." Dis Markers 32, no. 2 (2012): 133-141.

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Yamamura, S, Matsumura, N, Mandai, M, Huang, Z, Oura, T, Baba, T, Hamanishi, J, Yamaguchi, K, Kang, HS, Okamoto, T, Abiko, K, Mori, S, Murphy, SK, and Konishi, I. "The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer." Int J Cancer 130, no. 1 (January 1, 2012): 20-28.

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Skaar, DA, Li, Y, Bernal, AJ, Hoyo, C, Murphy, SK, and Jirtle, RL. "The Human Imprintome: Regulatory Mechanisms, Methods of Ascertainment, and Roles in Disease Susceptibility." ILAR JOURNAL 53, no. 3-4 (2012): 341-358.

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Murphy, SK, and Berchuck, A. "Ovarian cancer progenitor/stem cells: Therapeutic potential." (December 1, 2011): 223-244. (Chapter)

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