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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Garrett, ME, Moylan, CA, Gibson, J, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Abdelmalek, MF, Murphy, SK, Diehl, AM, Hauser, M, and Ashley-Koch, AE. "Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease." October 2012.

Scholars@Duke

Das, R, Anderson, N, Koran, MI, Weidman, JR, Mikkelsen, TS, Kamal, M, Murphy, SK, Linblad-Toh, K, Greally, JM, and Jirtle, RL. "Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. (Published online)" BMC Genomics 13 (August 16, 2012): 394-.

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Liu, Y, Murphy, SK, Murtha, AP, Fuemmeler, BF, Schildkraut, J, Huang, Z, Overcash, F, Kurtzberg, J, Jirtle, R, Iversen, ES, Forman, MR, and Hoyo, C. "Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements." Epigenetics 7, no. 7 (July 2012): 735-746.

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Perkins, E, Murphy, SK, Murtha, AP, Schildkraut, J, Jirtle, RL, Demark-Wahnefried, W, Forman, MR, Kurtzberg, J, Overcash, F, Huang, Z, and Hoyo, C. "Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children." The Journal of Pediatrics 161, no. 1 (July 2012): 31-39.

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Moylan, CA, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Ashley-Koch, AE, Garrett, ME, Abdelmalek, MF, Hauser, MA, Murphy, SK, and Diehl, AM. "Epigenetic Regulation of Gene Expression in NAFLD." May 2012.

Scholars@Duke

Huang, Z, Lowery, WJ, Berchuck, A, and Murphy, SK. "Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation." Cancer Research 72, no. 8 Supplement (April 15, 2012): 5363-5363.

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Okamoto, T, Yamaguchi, K, Huang, Z, Whitaker, R, Konishi, I, Berchuck, A, and Murphy, SK. "Abstract LB-87: Methylated-mediated repression of ZNF154 in ovarian cancer is associated with poor overall survival." Cancer Research 72, no. 8 Supplement (April 15, 2012): LB-87-LB-87.

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Hoyo, C, Fortner, K, Murtha, AP, Schildkraut, JM, Soubry, A, Demark-Wahnefried, W, Jirtle, RL, Kurtzberg, J, Forman, MR, Overcash, F, Huang, Z, and Murphy, SK. "Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight." Cancer Causes & Control : Ccc 23, no. 4 (April 2012): 635-645.

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Murphy, SK, Adigun, A, Huang, Z, Overcash, F, Wang, F, Jirtle, RL, Schildkraut, JM, Murtha, AP, Iversen, ES, and Hoyo, C. "Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke." Gene 494, no. 1 (February 2012): 36-43.

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Murphy, SK. "Targeting the epigenome in ovarian cancer." Future Oncol 8, no. 2 (February 2012): 151-164. (Review)

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