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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Bondurant, AE, Huang, Z, Whitaker, RS, Simel, LR, Berchuck, A, and Murphy, SK. "Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer." Gynecologic Oncology 123, no. 3 (December 2011): 581-587.

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Vidal, AC, Murphy, SK, Hernandez, BY, Vasquez, B, Bartlett, JA, Oneko, O, Mlay, P, Obure, J, Overcash, F, Smith, JS, van der Kolk, M, and Hoyo, C. "Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women. (Published online)" Infect Agent Cancer 6, no. 1 (November 14, 2011): 20-.

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Alvarez Secord, A, Darcy, KM, Hutson, A, Huang, Z, Lee, PS, Jewell, EL, Havrilesky, LJ, Markman, M, Muggia, F, and Murphy, SK. "The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study." Gynecol Oncol 123, no. 2 (November 2011): 314-319.

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Soubry, A, Murphy, S, Huang, Z, Murtha, A, Schildkraut, J, Jirtle, R, Wang, F, Kurtzberg, J, Demark-Wahnefried, W, Forman, M, and Hoyo, C. "The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring. (Published online)" Clin Epigenetics 3 (October 26, 2011): 2-.

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Hoyo, C, Murtha, AP, Schildkraut, JM, Jirtle, RL, Demark-Wahnefried, W, Forman, MR, Iversen, ES, Kurtzberg, J, Overcash, F, Huang, Z, and Murphy, SK. "Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy." Epigenetics 6, no. 7 (July 2011): 928-936.

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Zhang, A, Skaar, DA, Li, Y, Huang, D, Price, TM, Murphy, SK, and Jirtle, RL. "Novel retrotransposed imprinted locus identified at human 6p25." Nucleic Acids Res 39, no. 13 (July 2011): 5388-5400.

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Soubry, A, Murphy, SK, Huang, Z, Murtha, A, Schildkraut, JM, Jirtle, RL, Wang, F, Kurtzberg, J, Demark-Wahnefried, W, Forman, M, and Hoyo, C. "Abstract 2754: Maternal use of antidepressants in pregnancy is associated with hypermethylation at the IGF2 imprinted control regions in the offspring in a race-dependent fashion." Cancer Research 71, no. 8 Supplement (April 15, 2011): 2754-2754.

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Huang, Z, Yamaguchi, K, Berchuck, A, and Murphy, SK. "Abstract 3014: Quantitative accuracy of Illumina HumanMethylation27 Infinium BeadChip data assessed by pyrosequencing." Cancer Research 71, no. 8 Supplement (April 15, 2011): 3014-3014.

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Teoh, D, Ayeni, TA, Rubatt, JM, Adams, DJ, Grace, L, Starr, MD, Barry, WT, Berchuck, A, Murphy, SK, and Secord, AA. "Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells." Gynecologic Oncology 121, no. 1 (April 2011): 187-192.

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Kang, HS, Baba, T, Mandai, M, Matsumura, N, Hamanishi, J, Kharma, B, Kondoh, E, Yoshioka, Y, Oishi, S, Fujii, N, Murphy, SK, and Konishi, I. "GPR54 is a target for suppression of metastasis in endometrial cancer." Mol Cancer Ther 10, no. 4 (April 2011): 580-590.

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