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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Murphy, SK, Huang, Z, and Hoyo, C. "Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues." Plos One 7, no. 7 (January 2012): e40924-null.

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Hoyo, C, Murphy, SK, Schildkraut, JM, Vidal, AC, Skaar, D, Millikan, RC, Galanko, J, Sandler, RS, Jirtle, R, and Keku, T. "IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites." Disease Markers 32, no. 2 (January 2012): 133-141.

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Yamamura, S, Matsumura, N, Mandai, M, Huang, Z, Oura, T, Baba, T, Hamanishi, J, Yamaguchi, K, Kang, HS, Okamoto, T, Abiko, K, Mori, S, Murphy, SK, and Konishi, I. "The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer." Int J Cancer 130, no. 1 (January 1, 2012): 20-28.

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Skaar, DA, Li, Y, Bernal, AJ, Hoyo, C, Murphy, SK, and Jirtle, RL. "The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility." Ilar Journal 53, no. 3-4 (January 2012): 341-358. (Review)

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Murphy, SK, and Berchuck, A. "Ovarian cancer progenitor/stem cells: Therapeutic potential." (December 1, 2011): 223-244. (Chapter)

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Bondurant, AE, Huang, Z, Whitaker, RS, Simel, LR, Berchuck, A, and Murphy, SK. "Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer." Gynecologic Oncology 123, no. 3 (December 2011): 581-587.

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Vidal, AC, Murphy, SK, Hernandez, BY, Vasquez, B, Bartlett, JA, Oneko, O, Mlay, P, Obure, J, Overcash, F, Smith, JS, van der Kolk, M, and Hoyo, C. "Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women. (Published online)" Infect Agent Cancer 6, no. 1 (November 14, 2011): 20-.

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Alvarez Secord, A, Darcy, KM, Hutson, A, Huang, Z, Lee, PS, Jewell, EL, Havrilesky, LJ, Markman, M, Muggia, F, and Murphy, SK. "The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study." Gynecol Oncol 123, no. 2 (November 2011): 314-319.

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Soubry, A, Murphy, S, Huang, Z, Murtha, A, Schildkraut, J, Jirtle, R, Wang, F, Kurtzberg, J, Demark-Wahnefried, W, Forman, M, and Hoyo, C. "The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring. (Published online)" Clin Epigenetics 3 (October 26, 2011): 2-.

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Hoyo, C, Murtha, AP, Schildkraut, JM, Jirtle, RL, Demark-Wahnefried, W, Forman, MR, Iversen, ES, Kurtzberg, J, Overcash, F, Huang, Z, and Murphy, SK. "Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy." Epigenetics 6, no. 7 (July 2011): 928-936.

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