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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Zhang, A, Skaar, DA, Li, Y, Huang, D, Price, TM, Murphy, SK, and Jirtle, RL. "Novel retrotransposed imprinted locus identified at human 6p25." Nucleic Acids Res 39, no. 13 (July 2011): 5388-5400.

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Soubry, A, Murphy, SK, Huang, Z, Murtha, A, Schildkraut, JM, Jirtle, RL, Wang, F, Kurtzberg, J, Demark-Wahnefried, W, Forman, M, and Hoyo, C. "Abstract 2754: Maternal use of antidepressants in pregnancy is associated with hypermethylation at the IGF2 imprinted control regions in the offspring in a race-dependent fashion." Cancer Research 71, no. 8 Supplement (April 15, 2011): 2754-2754.

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Huang, Z, Yamaguchi, K, Berchuck, A, and Murphy, SK. "Abstract 3014: Quantitative accuracy of Illumina HumanMethylation27 Infinium BeadChip data assessed by pyrosequencing." Cancer Research 71, no. 8 Supplement (April 15, 2011): 3014-3014.

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Teoh, D, Ayeni, TA, Rubatt, JM, Adams, DJ, Grace, L, Starr, MD, Barry, WT, Berchuck, A, Murphy, SK, and Secord, AA. "Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells." Gynecologic Oncology 121, no. 1 (April 2011): 187-192.

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Kang, HS, Baba, T, Mandai, M, Matsumura, N, Hamanishi, J, Kharma, B, Kondoh, E, Yoshioka, Y, Oishi, S, Fujii, N, Murphy, SK, and Konishi, I. "GPR54 is a target for suppression of metastasis in endometrial cancer." Mol Cancer Ther 10, no. 4 (April 2011): 580-590.

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Hoyo, C, Murtha, AP, Schildkraut, JM, Forman, MR, Calingaert, B, Demark-Wahnefried, W, Kurtzberg, J, Jirtle, RL, and Murphy, SK. "Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)." Bmc Public Health 11, no. 1 (January 21, 2011): 46-null.

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Matsumura, N, Huang, Z, Mori, S, Baba, T, Fujii, S, Konishi, I, Iversen, ES, Berchuck, A, and Murphy, SK. "Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer." Genome Res 21, no. 1 (January 2011): 74-82.

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Bernal, AJ, Murphy, SK, and Jirtle, RL. "Mouse models of epigenetic inheritance." Handbook of Epigenetics (2011): 233-249.

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Matsumura, N, Mandai, M, Okamoto, T, Yamaguchi, K, Yamamura, S, Oura, T, Baba, T, Hamanishi, J, Kang, HS, Matsui, S, Mori, S, Murphy, SK, and Konishi, I. "Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling." Cancer Sci 101, no. 12 (December 2010): 2658-2663.

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Bernardini, MQ, Baba, T, Lee, PS, Barnett, JC, Sfakianos, GP, Secord, AA, Murphy, SK, Iversen, E, Marks, JR, and Berchuck, A. "Expression signatures of TP53 mutations in serous ovarian cancers." Bmc Cancer 10 (May 26, 2010): 237-null.

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